Zobrazeno 1 - 10
of 52
pro vyhledávání: '"James R Ault"'
Publikováno v:
eLife, Vol 10 (2021)
The PcrA/UvrD helicase binds directly to RNA polymerase (RNAP) but the structural basis for this interaction and its functional significance have remained unclear. In this work, we used biochemical assays and hydrogen-deuterium exchange coupled to ma
Externí odkaz:
https://doaj.org/article/db4351289616495e887dd60ee4c933e7
Autor:
Rhianna J. Rowland, Svitlana Korolchuk, Marco Salamina, Natalie J. Tatum, James R. Ault, Sam Hart, Johan P. Turkenburg, James N. Blaza, Martin E. M. Noble, Jane A. Endicott
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The cell division cycle 25 phosphatases CDC25A, B and C regulate cell cycle transitions by dephosphorylating residues in the conserved glycine-rich loop of CDKs to activate their activity. Here, we present the cryo-EM structure of CDK2-cycli
Externí odkaz:
https://doaj.org/article/7f9036edb0fb4c63978dfd51fe5e5873
Autor:
Sebastian Eves-van den Akker, Catherine J Lilley, James R Ault, Alison E Ashcroft, John T Jones, Peter E Urwin
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87289 (2014)
Plant parasitic nematodes comprise several groups; the most economically damaging of these are the sedentary endoparasites. Sedentary endoparasitic nematodes are obligate biotrophs and modify host root tissue, using a suite of effector proteins, to c
Externí odkaz:
https://doaj.org/article/a626fed41cb04a34a42342e2b1a403e3
Autor:
Selena G. Burgess, Nikki R. Paul, Mark W. Richards, James R. Ault, Laurie Askenatzis, Sophie G. Claydon, Ryan Corbyn, Laura M. Machesky, Richard Bayliss
Publikováno v:
Open Biology, Vol 14, Iss 3 (2024)
Fascin-1-mediated actin-bundling activity is central to the generation of plasma membrane protrusions required for cell migration. Dysregulated formation of cellular protrusions is observed in metastatic cancers, where they are required for increased
Externí odkaz:
https://doaj.org/article/b09d338e95f743cba49b2b823f0580ff
Publikováno v:
Journal of the American Society for Mass Spectrometry. 32:1583-1592
NMR studies and X-ray crystallography have shown that the structures of the 99-residue amyloidogenic protein β2-microglobulin (β2m) and its more aggregation-prone variant, D76N, are indistinguishable, and hence, the reason for the striking differen
Autor:
Kirill V. Sukhoverkov, Adam S.B. Jalal, James R. Ault, Frank Sobott, David M. Lawson, Tung B.K. Le
Publikováno v:
J Biol Chem
In Bacillus subtilis, a ParB-like nucleoid occlusion protein (Noc) binds specifically to Noc-binding sites (NBSs) on the chromosome to help coordinate chromosome segregation and cell division. Noc does so by binding to CTP to form large membrane-asso
Autor:
Miratul M. K. Muqit, Richard Bayliss, Thomas Macartney, James R. Ault, Ewelina Krysztofinska, Olawale G. Raimi, Poonam S. Kakade, Andrew M. Shaw, Atul Kumar, Kathrin Brockmann, Andrew D. Waddell, Sophie Burel, Mohd Ahanger, Hina Ojha, Julia C. Fitzgerald
Publikováno v:
Open Biology, Vol 12, Iss 1 (2022)
Open biology 12(1), 210264 (2022). doi:10.1098/rsob.210264
Open Biology
Open biology 12(1), 210264 (2022). doi:10.1098/rsob.210264
Open Biology
Human autosomal recessive mutations in the PINK1 gene are causal for Parkinson’s disease (PD). PINK1 encodes a mitochondrial localised protein kinase that is a master-regulator of mitochondrial quality control pathways. Structural studies to date h
Autor:
Owen, Cornwell, James R, Ault
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1870:140829
Fast photochemical oxidation of proteins (FPOP) is a hydroxyl radical footprinting approach whereby radicals, produced by UV laser photolysis of hydrogen peroxide, induce oxidation of amino acid side-chains. Mass Spectrometry (MS) is employed to loca
Autor:
Frank Sobott, Benjamin J. Lane, Antonio N. Calabrese, Bolin Wang, Hassane El Mkami, Charalampos Kapsalis, James R. Ault, Antreas C. Kalli, Christos Pliotas
The MscL channel gates in response to membrane tension changes to allow the exchange of molecules through its pore. Lipid removal from transmembrane pockets leads to a MscL response. However, it is unknown whether there is correlation between the ten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5577b9f9285bfbd02243069f7d73db2
https://doi.org/10.1101/2021.04.01.438050
https://doi.org/10.1101/2021.04.01.438050
Publikováno v:
Journal of the American Society for Mass Spectrometry. 32(7)
NMR studies and X-ray crystallography have shown that the structures of the 99-residue amyloidogenic protein β