Zobrazeno 1 - 10
of 85
pro vyhledávání: '"James R, Krycer"'
Autor:
Daniel J. Fazakerley, Julian van Gerwen, Kristen C. Cooke, Xiaowen Duan, Elise J. Needham, Alexis Díaz-Vegas, Søren Madsen, Dougall M. Norris, Amber S. Shun-Shion, James R. Krycer, James G. Burchfield, Pengyi Yang, Mark R. Wade, Joseph T. Brozinick, David E. James, Sean J. Humphrey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The failure of metabolic tissues to respond to insulin is an early marker of type 2 diabetes. Here, the authors show, using global phosphoproteomics, that insulin resistance is caused by a marked rewiring of both canonical and non-canonical insulin s
Externí odkaz:
https://doaj.org/article/1d1d85eedd7542a2a8117c06e8ff0883
Autor:
Daniel J. Fazakerley, James R. Krycer, Alison L. Kearney, Samantha L. Hocking, David E. James
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 10, Pp 1720-1732 (2019)
Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and cardiovascular disease. These disorders have dramatically increased in incidence with modern life, suggesting that excess nutrients and obesity are major c
Externí odkaz:
https://doaj.org/article/d7041b314fe84c94a2616c15b142c9df
Autor:
Deanne Francis, Shila Ghazanfar, Essi Havula, James R Krycer, Dario Strbenac, Alistair Senior, Annabel Y Minard, Thomas Geddes, Marin E Nelson, Fiona Weiss, Jacqueline Stöckli, Jean Y H Yang, David E James
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 10 (2021)
AbstractGenetic and environmental factors play a major role in metabolic health. However, they do not act in isolation, as a change in an environmental factor such as diet may exert different effects based on an individual’s genotype. Here, we soug
Externí odkaz:
https://doaj.org/article/22e39aa89e95440c9394f276fad33aca
Autor:
Lake-Ee Quek, James R. Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J. Fazakerley, Richard Scalzo, Sarah D. Elkington, Ziwei Dai, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Jason W. Locasale, Tomoyoshi Soga, David E. James, Shinya Kuroda
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101786- (2020)
Externí odkaz:
https://doaj.org/article/f9326031781b4a06a1113f66a90c237c
Autor:
Satoshi Ohno, Lake-Ee Quek, James R. Krycer, Katsuyuki Yugi, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Tomoyoshi Soga, David E. James, Shinya Kuroda
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101479- (2020)
Summary: Insulin regulates glucose metabolism through thousands of regulatory mechanisms; however, which regulatory mechanisms are keys to control glucose metabolism remains unknown. Here, we performed kinetic trans-omic analysis by integrating isoto
Externí odkaz:
https://doaj.org/article/5dcee48e0c5d42319ef09140d3fbbe36
Autor:
Michelle van Geldermalsen, Lake-Ee Quek, Nigel Turner, Natasha Freidman, Angel Pang, Yi Fang Guan, James R. Krycer, Renae Ryan, Qian Wang, Jeff Holst
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Cancer cells require increased levels of nutrients such as amino acids to sustain their rapid growth. In particular, leucine and glutamine have been shown to be important for growth and proliferation of some breast cancers, and th
Externí odkaz:
https://doaj.org/article/9e79dd67746c406cbf71738257ed22f4
Publikováno v:
BioTechniques, Vol 67, Iss 3, Pp 123-125 (2019)
Metabolism is often studied in animal models, with the Drosophila melanogaster fruit fly model offering ease of genetic manipulation and high-throughput studies. Fly metabolism is typically studied using end-point assays that are simple but destructi
Externí odkaz:
https://doaj.org/article/e4a825ebdeb44e4db1ec25f6f4e60059
Autor:
James R. Krycer, Katsuyuki Yugi, Akiyoshi Hirayama, Daniel J. Fazakerley, Lake-Ee Quek, Richard Scalzo, Satoshi Ohno, Mark P. Hodson, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Westa Domanova, Benjamin L. Parker, Marin E. Nelson, Sean J. Humphrey, Nigel Turner, Kyle L. Hoehn, Gregory J. Cooney, Tomoyoshi Soga, Shinya Kuroda, David E. James
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3536-3547 (2017)
Summary: Insulin triggers an extensive signaling cascade to coordinate adipocyte glucose metabolism. It is considered that the major role of insulin is to provide anabolic substrates by activating GLUT4-dependent glucose uptake. However, insulin stim
Externí odkaz:
https://doaj.org/article/193162bf744244048cb268ff37395957
Autor:
James R. Krycer, Ciana Diskin, Marin E. Nelson, Xiao-Yi Zeng, Daniel J. Fazakerley, David E. James
Publikováno v:
BioTechniques, Vol 64, Iss 1, Pp 27-29 (2018)
Research into cellular metabolism has become more high-throughput, with typical cell-culture experiments being performed in multiwell plates (microplates). This format presents a challenge when trying to collect gaseous products, such as carbon dioxi
Externí odkaz:
https://doaj.org/article/8585945efbd84c4a9807339ed7cf63a5
Autor:
James R. Krycer, Sam P. Nayler
Publikováno v:
The Cerebellum. 21:838-850
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29f3626a5c29ba26ee7d4ffbcce1fef9
https://doi.org/10.1007/s12311-022-01415-2
https://doi.org/10.1007/s12311-022-01415-2