Zobrazeno 1 - 10
of 43
pro vyhledávání: '"James R, Henry"'
Autor:
David S. Hong, Ramon V. Tiu, Michael S. Gordon, Ilaria Conti, Karim A. Benhadji, Sheng-Bin Peng, James R. Henry, Michael D. Kaufman, Daniel L. Flynn, KrisAnne Crowe, Andrew E. Schade, Danni Yu, Melinda D. Willard, Amanda Sykes, Ling Gao, Wei Zhang, Michael J. Millward, Jordi Rodon Ahnert, Geoffrey I. Shapiro, Keith T. Flaherty, Antoine Hollebecque, Ryan J. Sullivan
Supplementary Figure S2 shows two cases of patients treated at the RP2D. IHC at Clarient for p-ERK, p27 and Ki-67 were assessed for PD effect using monoclonal rabbit phospho-p44/42 MAPK (ERK1/2), 20G11 Clone; monoclonal mouse anti-Ki67, MIB-1 clone;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bffa344fba1fa66a45a3628b0bc99d4
https://doi.org/10.1158/1535-7163.22521469
https://doi.org/10.1158/1535-7163.22521469
Autor:
Sean G. Buchanan, James R. Henry, Robert M. Campbell, Christoph Reinhard, Gregory D. Plowman, David A. Barda, Xiang S. Ye, Hui-Rong Qian, Shaoyou Chu, Thompson Doman, Matthew Z. Dieter, Yu-Hua Hui, Scott W. Eastman, María José Lallena, Carmen Baquero, Carlos Marugán, Michele Dowless, Stephen R. Wasserman, Kenneth Weichert, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Ann M. Mc Nulty, Stephen Antonysamy, Avnish Kapoor, Li Fan, Chris Ficklin, Huimin Bian, Sufang Yao, Shaoling Jin, Bomie Han, Wayne Blosser, Xi Lin, Robert D. Van Horn, Li-Chun Chio, Philip W. Iversen, Yue Webster, Farhana F. Merzoug, Stephen H. Parsons, Jian Du, Xueqian Gong
LY3295668 chemical characterization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459c3119cab021ba3189b2c2e7d96d2e
https://doi.org/10.1158/2159-8290.22533034.v1
https://doi.org/10.1158/2159-8290.22533034.v1
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ab9e588f7270d239b69faebcc24e90
https://doi.org/10.1158/1535-7163.22506969.v1
https://doi.org/10.1158/1535-7163.22506969.v1
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression. Aurora A depletion primarily leads to mitotic spindle formation defects and consequently prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0aca539a9e32036f4566410352eeff32
https://doi.org/10.1158/1535-7163.c.6538536.v1
https://doi.org/10.1158/1535-7163.c.6538536.v1
Autor:
Sean G. Buchanan, James R. Henry, Robert M. Campbell, Christoph Reinhard, Gregory D. Plowman, David A. Barda, Xiang S. Ye, Hui-Rong Qian, Shaoyou Chu, Thompson Doman, Matthew Z. Dieter, Yu-Hua Hui, Scott W. Eastman, María José Lallena, Carmen Baquero, Carlos Marugán, Michele Dowless, Stephen R. Wasserman, Kenneth Weichert, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Ann M. Mc Nulty, Stephen Antonysamy, Avnish Kapoor, Li Fan, Chris Ficklin, Huimin Bian, Sufang Yao, Shaoling Jin, Bomie Han, Wayne Blosser, Xi Lin, Robert D. Van Horn, Li-Chun Chio, Philip W. Iversen, Yue Webster, Farhana F. Merzoug, Stephen H. Parsons, Jian Du, Xueqian Gong
shRNA suppressor screening data for H446 and MDA-MB-468 cells (tabs 1, 2) and RNA expression level associations with LY3295668 Abs IC50 values from 493 cancer cell lines (tab 3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7062b69c7f18848d7e882885812c96
https://doi.org/10.1158/2159-8290.22533025.v1
https://doi.org/10.1158/2159-8290.22533025.v1
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b687d979fb87e1752e656129b11b4a8
https://doi.org/10.1158/1535-7163.22506966
https://doi.org/10.1158/1535-7163.22506966
Autor:
Sean G. Buchanan, James R. Henry, Robert M. Campbell, Christoph Reinhard, Gregory D. Plowman, David A. Barda, Xiang S. Ye, Hui-Rong Qian, Shaoyou Chu, Thompson Doman, Matthew Z. Dieter, Yu-Hua Hui, Scott W. Eastman, María José Lallena, Carmen Baquero, Carlos Marugán, Michele Dowless, Stephen R. Wasserman, Kenneth Weichert, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Ann M. Mc Nulty, Stephen Antonysamy, Avnish Kapoor, Li Fan, Chris Ficklin, Huimin Bian, Sufang Yao, Shaoling Jin, Bomie Han, Wayne Blosser, Xi Lin, Robert D. Van Horn, Li-Chun Chio, Philip W. Iversen, Yue Webster, Farhana F. Merzoug, Stephen H. Parsons, Jian Du, Xueqian Gong
Supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071e82c7fa2f25274a31dc41f9817c55
https://doi.org/10.1158/2159-8290.22533037
https://doi.org/10.1158/2159-8290.22533037
Autor:
Sheng-Bin Peng, Gregory D. Plowman, James J. Starling, James R. Henry, Ilaria Conti, Lysiane Huber, Yong Gang Yue, Swee Seong Wong, Igor Mochalkin, Vipin Yadav, Sean Buchanan, Tinggui Yin, Robert D. Van Horn, Youyan Zhang, Shih-Hsun Chen
Supplementary Figure S1. Validation of BRAF deletion in BxPC-3 cells by Sanger's sequencing method. Supplementary Figure S2. BRAF deletion (deltaBRAF), but not WT BRAF, is able to transform cells. Supplementary Figure S3. Validation of in situ PLA in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436628872cb0b1f40e19a206dbd41888
https://doi.org/10.1158/2159-8290.22531479
https://doi.org/10.1158/2159-8290.22531479
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9753ae2ef1911fad6be7d03eb93839c9
https://doi.org/10.1158/1535-7163.22506972.v1
https://doi.org/10.1158/1535-7163.22506972.v1
Autor:
Sheng-Bin Peng, Gregory D. Plowman, Ramon V. Tiu, James R. Henry, Amit Aggarwal, Jason C. Ting, Steven Bray, Philip Ebert, Yue Wang Webster, Ruslan D. Novosiadly, Amelie Forest, Robert D. Van Horn, Youyan Zhang, Philip W. Iversen, Gregory P. Donoho, Yung-mae M. Yao
Purpose: To evaluate the antitumor efficacy of cetuximab in combination with LSN3074753, an analog of LY3009120 and pan-RAF inhibitor in 79 colorectal cancer patient-derived xenograft (PDX) models.Experimental Design: Seventy-nine well-characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92cd051fadba964dc0ea8b343c15323d
https://doi.org/10.1158/1078-0432.c.6527070
https://doi.org/10.1158/1078-0432.c.6527070