Zobrazeno 1 - 10
of 87
pro vyhledávání: '"James R, Gage"'
Autor:
Miguel Gonzalez, James R. Gage, Jian Tao, Jiang Yong, Furong Chen, Luo Yong, Mark D. McLaws, Changming Dong
Publikováno v:
Organic Process Research & Development. 24:2025-2033
A two-stage flow process for cGMP manufacture of a commercially important carbapenem intermediate was developed. Stage 1 featured an intramolecular N–H insertion reaction catalyzed by an immobilize...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ae445dc4bad265e25a21449b152d99f
https://doi.org/10.1021/acs.oprd.0c00133
https://doi.org/10.1021/acs.oprd.0c00133
Autor:
Kaid C. Harper, Yi-Yin Ku, Srinivas Grangula, Jeremy Griffin, Jia-long Yuan, Ning-ning Zhang, James R. Gage, Timothy Towne, Ping-zhong Huang, Song-yuan Zheng, Daniel J. Mack, Moiz Diwan, En-xuan Zhang, Robert W. Miller, Zhi-qing Liu, Timothy A. Grieme
Despite the growth of photoredox methods in academia, application of photoredox at scale in the pharmaceutical and fine chemical industries has been slow. In this report, a photoredox trifluoromethylation of a thiophenol was modified from the origina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a56e0229b56d06c2c27415db437cd5
https://doi.org/10.33774/chemrxiv-2021-z3xm8-v2
https://doi.org/10.33774/chemrxiv-2021-z3xm8-v2
Autor:
Martin Olbrich, Andrew S. Wells, Isamir Martinez, Edward C. Sherer, Martin D. Eastgate, Stefan G. Koenig, Frank Roschangar, Fabrice Gallou, Jun Li, David K. Leahy, Michael E. Kopach, Christiana Briddell, Barry Richard Dillon, Jacob Albrecht, Jared L. Piper, Louis J. Diorazio, Alina Borovika, James R. Gage
Publikováno v:
Nature Sustainability. 2:1034-1040
The development of sustainable processes for the synthesis of new clinical candidates is a priority for every pharmaceutical company. The ultimate efficiency of a molecule’s synthesis results from a combination of the sequence of steps to assemble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b8b3975653f387b3fd689f547b3e7c7
https://doi.org/10.1038/s41893-019-0400-5
https://doi.org/10.1038/s41893-019-0400-5
Publikováno v:
ACS Catalysis. 8:1528-1531
The potential role of dimeric catalyst species on or off the catalytic cycle is considered for a case of Pd-catalyzed C–H functionalization, leading to the development of a general experimental protocol that uses the reaction itself to report on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cef640c28c9e8160e13f983d99b00589
https://doi.org/10.1021/acscatal.8b00103
https://doi.org/10.1021/acscatal.8b00103
Autor:
Jacob Albrecht, Martin D. Eastgate, David K. Leahy, Frank Roschangar, Fabrice Gallou, Jun Li, Michael E. Kopach, James R. Gage, Barry Richard Dillon, Christiana Briddell, Martin Olbrich, Alina Borovika, Jared L. Piper, Louis J. Diorazio, Andrew S. Wells, Isamir Martinez, Edward C. Sherer, Stefan G. Koenig
Herein we describe a green-by-design approach to route selection and development, assisted by predictive analytics and historical data. In order to aid the selection of more efficient strategies, we created a user-friendly web application, the “PMI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6487a7b56868f08865916e85613ead7f
https://doi.org/10.26434/chemrxiv.7594646.v1
https://doi.org/10.26434/chemrxiv.7594646.v1
Publikováno v:
Organic Process Research & Development. 16:930-933
The design and use of a flow reactor for scaling up an exothermic nitration reaction in a safe manner on production scale is described. The flow reactor is made of a jacketed, stainless steel coil. Two charging methods, pump and nitrogen pressure wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a971ed8d406bd0180bf212dc73790b05
https://doi.org/10.1021/op2003425
https://doi.org/10.1021/op2003425
Publikováno v:
Gait & Posture. 33:1-5
Crouch gait is common in individuals with cerebral palsy. Recently published data has shown that distal femoral extension osteotomy with patellar tendon advancement (DFEO/PTA) is an effective procedure to correct crouch gait in the presence of a knee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf5b1a59be9870b64272374fc929fd7
https://doi.org/10.1016/j.gaitpost.2010.08.014
https://doi.org/10.1016/j.gaitpost.2010.08.014
Publikováno v:
Europe PubMed Central
Stance phase stability and swing phase clearance, prerequisites for normal ambulation, often are lost in the gait of children with cerebral palsy. Lengthening of the hamstrings usually will improve stance-phase knee extension but will not greatly alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb44f8a910f98e7f21eec70b206a9c9
https://doi.org/10.1111/j.1469-8749.1987.tb02131.x
https://doi.org/10.1111/j.1469-8749.1987.tb02131.x
Publikováno v:
The Journal of Bone and Joint Surgery-American Volume. 90:2470-2484
FROM THE ORIGINAL ARTICLE BACKGROUND: Hallmarks of a persistent crouched walking pattern exhibited by individuals with cerebral palsy usually include loss of an adequate plantar flexion/knee extension couple, hamstring and/or psoas tightness, or cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077fa74308097a21257baf3125ee32c0
https://doi.org/10.2106/jbjs.g.00327
https://doi.org/10.2106/jbjs.g.00327
Publikováno v:
Journal of Biomechanics. 39:689-698
Stiff-knee gait is a movement abnormality in which knee flexion during swing phase is significantly diminished. This study investigates the relationships between knee flexion velocity at toe-off, joint moments during swing phase and double support, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f87168952beea692b8adf7d43b0e23e
https://doi.org/10.1016/j.jbiomech.2005.01.015
https://doi.org/10.1016/j.jbiomech.2005.01.015