Zobrazeno 1 - 10
of 40
pro vyhledávání: '"James R, Falconer"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 675 (2024)
The transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) has the potential to overcome some of the major disadvantages relating to oral NSAID usage, such as gastrointestinal adverse events and compliance. However, the poor solubilit
Externí odkaz:
https://doaj.org/article/9fb07c84a764485986ffd78cf84b273c
Autor:
Madeleine S. A. Tan, Preeti Pandey, James R. Falconer, Dan J. Siskind, Alexandra Balmanno, Harendra S. Parekh
Publikováno v:
Gels, Vol 8, Iss 1, p 38 (2022)
(1) Background: Clozapine is the most effective antipsychotic. It is, however, associated with many adverse drug reactions. Nose-to-brain (N2B) delivery offers a promising approach. This study aims to develop clozapine-encapsulated thermosensitive so
Externí odkaz:
https://doaj.org/article/58cae52c10f84ce894b2a34a3b801b1a
Publikováno v:
Biology, Vol 10, Iss 6, p 481 (2021)
In this study, the optimal setup of supercritical fluid extraction (SFE) was designed and developed, leading to the quantitation of 11 distinct cannabinoids (cannabidivann (CBDV), tetrahydrocannabivann (THCV), cannabidiol (CBD), cannabigerol (CBG) ca
Externí odkaz:
https://doaj.org/article/7315c27189394cb2adaf8f3bd7ae11b5
Autor:
Madeleine S. A. Tan, Preeti Pandey, Rink-Jan Lohman, James R. Falconer, Dan J. Siskind, Harendra S. Parekh
Publikováno v:
Molecular pharmaceutics. 19(11)
Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia. However, it causes many adverse drug reactions (ADRs), which lead to poor treatment outcomes. Nose-to-brain (N2B) drug delivery offers a promising approach to reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26f7787dee2d16610175026e72f275a
https://pubmed.ncbi.nlm.nih.gov/36149013
https://pubmed.ncbi.nlm.nih.gov/36149013
Autor:
Andrew K. Whittaker, Maree T. Smith, Felicity Y. Han, Tushar Kumeria, James R. Falconer, Weizhi Xu, Zonglan Zhao, Amirali Popat
Publikováno v:
Drug Delivery and Translational Research. 12:676-694
Ketamine in sub-anaesthetic doses has analgesic properties and an opioid-sparing effect. Intrathecal (i.t.) delivery of analgesics bypasses systemic metabolism and delivers the analgesic agent adjacent to the target receptors in the spinal cord and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42d8b9bef52b893bc4d6a5069dac3f18
https://doi.org/10.1007/s13346-021-00991-w
https://doi.org/10.1007/s13346-021-00991-w
Autor:
James R. Falconer, Peter J. Cabot, Amirali Popat, Fekade B. Sime, Jason A. Roberts, Aun Raza, Tushar Kumeria, Shih Chen Ngieng
Publikováno v:
Drug Discovery Today. 26:551-560
An increase in the number of multidrug-resistant microbial strains is the biggest threat to global health and is projected to cause >10 million deaths by 2055. The carbapenem family of antibacterial drugs are an important class of last-resort treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048f4261248ea092cd72ab0b10d9671e
https://doi.org/10.1016/j.drudis.2020.11.004
https://doi.org/10.1016/j.drudis.2020.11.004
Autor:
Jason A. Roberts, James R. Falconer, Aun Raza, Peter J. Cabot, Fekade B. Sime, Amirali Popat, Tushar Kumeria
Publikováno v:
ACS Biomaterials Science & Engineering. 7:1836-1853
Meropenem (MER) is an effective broad-spectrum antibiotic currently only available in the parenteral form requiring frequent drug preparation and administration due to its extremely poor stability. The unavailability of oral Meropenem is primarily du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3d7306b1b61d45d19c420fc1f1ca4c4
https://doi.org/10.1021/acsbiomaterials.0c01284
https://doi.org/10.1021/acsbiomaterials.0c01284
Autor:
James R. Falconer, Tushar Kumeria, Yuxue Cao, Amirali Popat, Mark A. T. Blaskovich, John Ndayishimiye
Publikováno v:
Journal of Materials Chemistry B. 9:7145-7166
Vancomycin (Van) is a key antibiotic of choice for the treatment of systemic methicillin resistant Staphylococcus aureus (MRSA) infections. However, due to its poor membrane permeability, it is administered parenterally, adding to the cost and effort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823554152ffafa32ebca85e90d8575c7
https://doi.org/10.1039/d1tb01430g
https://doi.org/10.1039/d1tb01430g
Autor:
Jingyuan Wen, James R. Falconer, Nataly Martini, Michelle Locke, Zimei Wu, Mengyang Liu, Danhui Li
Publikováno v:
Journal of Drug Targeting. 29:310-322
Numerous skin disorders and diseases are related to oxidative stress. The application of an antioxidant, serving as a strong defense agent against oxidation, is of great interest in dermatology yet remains challenging for delivery. This paper aimed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1344ff50842e7fe61cc33616bbb80313
https://doi.org/10.1080/1061186x.2020.1835923
https://doi.org/10.1080/1061186x.2020.1835923
Autor:
Madeleine S. A. Tan, Preeti Pandey, James R. Falconer, Dan J. Siskind, Alexandra Balmanno, Harendra S. Parekh
Publikováno v:
Gels
Gels, Vol 8, Iss 38, p 38 (2022)
Gels; Volume 8; Issue 1; Pages: 38
Gels, Vol 8, Iss 38, p 38 (2022)
Gels; Volume 8; Issue 1; Pages: 38
(1) Background: Clozapine is the most effective antipsychotic. It is, however, associated with many adverse drug reactions. Nose-to-brain (N2B) delivery offers a promising approach. This study aims to develop clozapine-encapsulated thermosensitive so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25d5472776c21bbe0c15ec6331f0f99
https://pubmed.ncbi.nlm.nih.gov/35049572
https://pubmed.ncbi.nlm.nih.gov/35049572