Zobrazeno 1 - 10
of 51
pro vyhledávání: '"James Pickel"'
Autor:
Antony Cougnoux, Rebecca A. Drummond, Mason Fellmeth, Fatemeh Navid, Amanda L. Collar, James Iben, Ashok B. Kulkarni, James Pickel, Raphael Schiffmann, Christopher A. Wassif, Niamh X. Cawley, Michail S. Lionakis, Forbes D. Porter
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Abstract Background Lysosomal storage diseases (LSD) are a large family of inherited disorders characterized by abnormal endolysosomal accumulation of cellular material due to catabolic enzyme and transporter deficiencies. Depending on the affected m
Externí odkaz:
https://doaj.org/article/7536ce5bd31a4b64979c1f6f4a63ba3a
Autor:
Kapil Bharti, Melanie Gasper, Jingxing Ou, Martha Brucato, Katharina Clore-Gronenborn, James Pickel, Heinz Arnheiter
Publikováno v:
PLoS Genetics, Vol 8, Iss 7, p e1002757 (2012)
The separation of the optic neuroepithelium into future retina and retinal pigment epithelium (RPE) is a critical event in early eye development in vertebrates. Here we show in mice that the transcription factor PAX6, well-known for its retina-promot
Externí odkaz:
https://doaj.org/article/3f0aeadd99b34192a31895e3ef23b7cd
Autor:
Reinis Svarcbahs, Sarah M. Blossom, Helena S. Baffoe-Bonnie, Kathleen A. Trychta, Lacey K. Greer, James Pickel, Mark J. Henderson, Brandon K. Harvey
Publikováno v:
Transgenic Research. 32:209-221
Maintenance of calcium homeostasis is important for proper endoplasmic reticulum (ER) function. When cellular stress conditions deplete the high concentration of calcium in the ER, ER-resident proteins are secreted into the extracellular space in a p
Autor:
Miguel Chuapoco, Nicholas Flytzanis, Nick Goeden, J Octeau, Kristina Roxas, Ken Chan, Jon Scherrer, Janet Winchester, Roy Blackburn, Lillian Campos, Kwun-Nok Man, Junqing Sun, Xinhong Chen, Arthur Lefevre, Vikram Singh, Cynthia Arokiaraj, Timothy Miles, Julia Vendemiatti, Min Jang, John Mich, Yeme Bishaw, Bryan Gore, Victora Omstead, Naz Taskin, Natalie Weed, Jonathan Ting, Cory Miller, Benjamin Deverman, James Pickel, Lin Tian, Andrew Fox, Viviana Gradinaru
Adeno-associated viruses (AAVs) promise robust gene delivery to the brain through non-invasive, intravenous delivery. However, unlike in rodents, few neurotropic AAVs efficiently cross the blood-brain barrier in non-human primates (NHPs). Here we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e3192103b15fe3a881efdffe7581737
https://doi.org/10.21203/rs.3.rs-1370972/v1
https://doi.org/10.21203/rs.3.rs-1370972/v1
Autor:
Kenneth A. Pelkey, Geoffrey Vargish, Leonardo Pellegrini, Daniela Calvigioni, Julio Chapeton, Xiaoqing Yuan, Steven Hunt, Alexander Cummins, Mark Eldridge, James Pickel, Ramesh Chittajallu, Bruno Averbeck, Katalin Toth, Kareem Zaghloul, Chris McBain, Sneak Peek Administrator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d66a46052145fc19d8e7af3b7eda7c71
https://doi.org/10.2139/ssrn.4354091
https://doi.org/10.2139/ssrn.4354091
Autor:
Miguel R. Chuapoco, Nicholas C. Flytzanis, Nick Goeden, J. Christopher Octeau, Kristina M. Roxas, Ken Y. Chan, Jon Scherrer, Janet Winchester, Roy J. Blackburn, Lillian J. Campos, Cynthia M. Arokiaraj, Timothy F. Miles, Min J. Jang, Julia Vendemiatti, Benjamin E. Deverman, James Pickel, Andrew S. Fox, Viviana Gradinaru
Adeno-associated viruses (AAVs) can enable robust and safe gene delivery to the mammalian central nervous system (CNS). While the scientific community has developed numerous neurotropic AAV variants for systemic gene-transfer to the rodent brain, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa752b987e8f89af2f958f76efad422b
https://doi.org/10.1101/2022.01.08.475342
https://doi.org/10.1101/2022.01.08.475342
Autor:
Raghuveer Kavarthapu, Chon-Hwa Tsai Morris, Rajakumar Anbazhagan, Murugananthkumar Raju, James Pickel, Maria L. Dufau
Publikováno v:
Hum Mol Genet
Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) is a testis specific member of the DEAD-box family of RNA helicases expressed in meiotic and haploid germ cells which plays an essential role in spermatogenesis. There are two species of GRT
Autor:
Alexander Cummins, Nick Goeden, Nicholas C. Flytzanis, James Pickel, Viviana Gradinaru, David Goertsen
Genetic intervention is increasingly explored as a therapeutic option for debilitating disorders of the central nervous system. The safety and efficacy of gene therapies relies upon expressing a transgene in affected cells while minimizing off-target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17863f3fb83017f6cd00159379a9acf6
https://doi.org/10.1101/2020.06.16.152975
https://doi.org/10.1101/2020.06.16.152975
Autor:
David Goertsen, Nicholas C. Flytzanis, Nick Goeden, Miguel R. Chuapoco, Alexander Cummins, Yijing Chen, Yingying Fan, Qiangge Zhang, Jitendra Sharma, Yangyang Duan, Liping Wang, Guoping Feng, Yu Chen, Nancy Y. Ip, James Pickel, Viviana Gradinaru
Publikováno v:
Nature neuroscience. 25(1)
Genetic intervention is increasingly being explored as a therapeutic option for debilitating disorders of the central nervous system. The safety and efficacy of gene therapies rely upon expressing a transgene in affected cells while minimizing off-ta
Autor:
Forbes D. Porter, James Pickel, James R. Iben, Amanda L. Collar, Michail S. Lionakis, Rebecca A. Drummond, Fatemeh Navid, Mason Fellmeth, Raphael Schiffmann, Antony Cougnoux, Niamh X. Cawley, Ashok B. Kulkarni, Christopher A. Wassif
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Background Lysosomal storage diseases (LSD) are a large family of inherited disorders characterized by abnormal endolysosomal accumulation of cellular material due to catabolic enzyme and transporter deficiencies. Depending on the affected metabolic