Zobrazeno 1 - 7
of 7
pro vyhledávání: '"James Picado-Leonard"'
Autor:
Synthia H. Mellon, Chris C. D. Moore, Walter L. Miller, Steven T. Brentano, James Picado-Leonard
Publikováno v:
Molecular Endocrinology. 4:1972-1979
Cytochrome P450c17 is the single microsomal enzyme catalyzing steroid 17 alpha-hydroxylase and 17-20-lyase activities. It is expressed and regulated by tropic hormones in the human adrenal and gonads, but is not expressed in the placenta. To study th
Autor:
Walter L. Miller, James Picado-Leonard
Publikováno v:
DNA. 6:439-448
P450c17 is a single cytochrome P450 enzyme mediating both 17α-hydroxylase and 17,20 lyase activities in the biosynthesis of steroid hormones. We have cloned and sequenced the human P450XVIIA1 gene lying on chromosome 10, which encodes P450c17. The g
Autor:
James Picado-Leonard, Walter L. Miller
Publikováno v:
Molecular Endocrinology. 2:1145-1150
The amino acid sequences of two steroidogenic enzymes, P450c17 (steroid 17α-hydroxylase/17,20 lyse) and P450c21 (steroid 21-hydroxylase), are only 28.9% identical. However, these proteins share a region of 21 amino acids bearing 17 identical residue
Autor:
Bon Chu Chung, James Picado-Leonard, Lee-Chuan Kao, J. F. Strauss, Walter L. Miller, Raimo Voutilainen
Publikováno v:
Scopus-Elsevier
Adrenodoxin is an iron-sulfur protein serving as an electron transport intermediate for two mitochondrial steroidogenic cytochromes P450. We have cloned and sequenced three human adrenal adrenodoxin cDNAs. The longest 5‘-untranslated region was 131
Autor:
Walter L. Miller, Israel Hanukoglu, Yves Morel, Sharyn B. Solish, Robert W. Kuhn, T. K. Mohandas, James Picado-Leonard
Publikováno v:
Proceedings of the National Academy of Sciences. 85:7104-7108
Adrenodoxin reductase is a mitochondrial flavoprotein that receives electrons from NADPH, thus initiating the electron-transport chain serving mitochondrial cytochromes P450. We have cloned and sequenced two human adrenodoxin reductase cDNAs that dif
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 63:789-791
P450c17 is the single enzyme mediating both 17 alpha-hydroxylase and 17,20 lyase activities. We identified several human P450c17 cDNA clones in a human adrenal cDNA library we constructed in lambda gt10. A short clone containing the 3'-terminal 650 b
Publikováno v:
The Journal of clinical endocrinology and metabolism. 66(2)
Adrenodoxin is an iron-sulfur protein found in the mitochondria of steroidogenic tissues. It participates in steroidogenesis as an electron transport intermediate for mitochondrial cytochromes P450, including P450scc, the cholesterol side-chain cleav