Zobrazeno 1 - 10
of 15
pro vyhledávání: '"James Peek"'
Autor:
James Peek, Mirjana Lilic, Daniel Montiel, Aleksandr Milshteyn, Ian Woodworth, John B. Biggins, Melinda A. Ternei, Paula Y. Calle, Michael Danziger, Thulasi Warrier, Kohta Saito, Nathaniel Braffman, Allison Fay, Michael S. Glickman, Seth A. Darst, Elizabeth A. Campbell, Sean F. Brady
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Resistance to rifamycin antibiotics, which target bacterial RNA polymerases, is a growing problem. Here, the authors identify gene clusters from soil metagenomes encoding production of rifamycin analogues that are active against rifampicin-resistant
Externí odkaz:
https://doaj.org/article/9a2754d11dc34b7e92b8fd4db1a27cbf
Autor:
James Peek, Steven Park, David S. Perlin, Jiayi Xu, Matthew D. Zimmerman, Sean F. Brady, Riccardo Russo, Shraddha Suryavanshi, Han Wang
Publikováno v:
ACS Infectious Diseases
Semisynthetic rifamycin derivatives such as rifampicin (Rif) are first line treatments for tuberculosis and other bacterial infections. Historically, synthetic modifications made to the C-3/C-4 region of the rifamycin naphthalene core, like those see
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf9b87a491a6cf79bf2f216ec0214e3
http://europepmc.org/articles/PMC7497472
http://europepmc.org/articles/PMC7497472
Publikováno v:
Behavioural Public Policy. 6:439-463
We explore whether simple behavioural insights techniques can be successful for addressing a policy issue within one of society's more complex and difficult sectors: child protection. Child protection reporting practices in New South Wales, Australia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7922c4c139d6ece7ee08231403adf061
https://doi.org/10.1017/bpp.2019.12
https://doi.org/10.1017/bpp.2019.12
Publikováno v:
Bioorg Med Chem Lett
Bacterial resistance threatens the utility of currently available antibiotics. Rifampicin, a cornerstone in the treatment of persistent Gram-positive infections, is prone to the development of resistance resulting from single point mutations in the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0107e897d95b1bf89266538234198af7
https://doi.org/10.1016/j.bmcl.2021.128484
https://doi.org/10.1016/j.bmcl.2021.128484
Publikováno v:
The Plant journal : for cell and molecular biology.
Quinate is produced and used by many plants in the biosynthesis of chlorogenic acids (CGAs). Chlorogenic acids are astringent and serve to deter herbivory. They also function as antifungal agents and have potent antioxidant properties. Quinate is pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adfac10651b243cc449df4ebe3dbaa95
https://pubmed.ncbi.nlm.nih.gov/29890023
https://pubmed.ncbi.nlm.nih.gov/29890023
Autor:
James Peek, Dinesh Christendat
Publikováno v:
Archives of Biochemistry and Biophysics. 566:85-99
Shikimate dehydrogenase (SDH) catalyzes the NADPH-dependent reduction of 3-deydroshikimate to shikimate, an essential reaction in the biosynthesis of the aromatic amino acids and a large number of other secondary metabolites in plants and microbes. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582182a04aa4fd6f33cfcdc1f1316ba6
https://doi.org/10.1016/j.abb.2014.12.006
https://doi.org/10.1016/j.abb.2014.12.006
Publikováno v:
Molecular and Biochemical Parasitology. 194:16-19
The apicomplexan parasite Toxoplasma gondii, the etiologic agent of toxoplasmosis, is estimated to infect 10-80% of different human populations. T. gondii encodes a large pentafunctional polypeptide known as the AROM complex which catalyzes five reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a59dfdab7f6e9e39286139ec2dbadba
https://doi.org/10.1016/j.molbiopara.2014.04.002
https://doi.org/10.1016/j.molbiopara.2014.04.002
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1834:516-523
The shikimate dehydrogenase (SDH) family consists of enzymes with diverse roles in secondary metabolism. The two most widespread members of the family, AroE and YdiB, function in amino acid biosynthesis and quinate catabolism, respectively. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69aced40595283a31c3bba5c673107df
https://doi.org/10.1016/j.bbapap.2012.10.016
https://doi.org/10.1016/j.bbapap.2012.10.016
Publikováno v:
Molecular microbiology. 103(1)
Quinate and shikimate can be degraded by a number of microbes. Dehydroshikimate dehydratases (DSDs) play a central role in this process, catalyzing the conversion of 3-dehydroshikimate to protocatechuate, a common intermediate of aromatic degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66414ac389295d772d5d9b87efd0b04
https://pubmed.ncbi.nlm.nih.gov/27706847
https://pubmed.ncbi.nlm.nih.gov/27706847
Publikováno v:
Biochemistry. 50:8616-8627
Shikimate dehydrogenase (SDH) catalyzes the reversible NADPH-dependent reduction of 3-dehydroshikimate to shikimate. This reaction represents the fourth step of the shikimate pathway, the essential route for the biosynthesis of the aromatic amino aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8395637ee41bfe50f2fbab1610e5facb
https://doi.org/10.1021/bi200586y
https://doi.org/10.1021/bi200586y