Zobrazeno 1 - 10
of 32
pro vyhledávání: '"James P. Wynn"'
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
IntroductionSepsis is a common cause of morbidity and mortality in the neonatal intensive care unit (NICU). The frequency and severity of sepsis-associated coagulopathy as well as its relationship to illness severity are unclear.MethodsWe performed a
Externí odkaz:
https://doaj.org/article/0b7336384aec498abe21c2bf37f3c3b1
Autor:
Petek Eylul Taneri, Jamie J Kirkham, Eleanor J Molloy, Linda Biesty, Richard A Polin, James L Wynn, Barbara J Stoll, Niranjan Kissoon, Kondwani Kawaza, Mandy Daly, Aoife Branagan, Lívia Nagy Bonnard, Eric Giannoni, Tobias Strunk, Magdalena Ohaja, Kenneth Mugabe, Denise Suguitani, Fiona Quirke, Declan Devane
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0295325 (2023)
Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) fo
Externí odkaz:
https://doaj.org/article/d7adef3b582741aca32a36188b4b3c3e
Autor:
Kusum Menon, MD, MSc, Luregn J. Schlapbach, MD, Samuel Akech, MBChB, MMED, Andrew Argent, MBBCh, MD, Kathleen Chiotos, MD, MSCE, Mohammod Jobayer Chisti, MBBS, MMed, PhD, Jemila Hamid, PhD, Paul Ishimine, MD, Niranjan Kissoon, MD, Rakesh Lodha, MD, Cláudio Flauzino Oliveira, MD, Mark Peters, MBChB, PhD, Pierre Tissieres, MD, PhD, R. Scott Watson, MD, MPH, Matthew O. Wiens, PharmD, PhD, James L. Wynn, MD, Lauren R. Sorce, BSN, PhD, for the Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine, Luregn J. Schlapbach, R. Scott Watson, Andrew Argent, Lauren R. Sorce, Elizabeth R. Alpern, Fran Balamuth, Tellen D. Bennett, Paolo Biban, Joe Carcillo, Enitan Carrol, Kathleen Chiotos, Mohammod Jobayer Chisti, Idris Evans, Lu Guoping, Mark W. Hall, David Inwald, Paul Ishimine, Michael Levin, Niranjan (Tex) Kissoon, Rakesh Lodha, Kathryn Maitland, Simon Nadel, Satoshi Nakagawa, Claudio Flauzino Oliveira, Mark Peters, Adrienne G. Randolph, Suchitra Ranjit, L. Nelson Sanchez-Pinto, Halden F. Scott, Daniela Carla Souza, Paul Tissieres, Juliane Bubeck Wardenburg, Scott L. Weiss, Wilson Milton Were, Matt Wiens, James L. Wynn, Jerry J. Zimmerman
Publikováno v:
Critical Care Explorations, Vol 2, Iss 6, p e0123 (2020)
Objectives:. Sepsis is responsible for a substantial proportion of global childhood morbidity and mortality. However, evidence demonstrates major inaccuracies in the use of the term “sepsis” in clinical practice, coding, and research. Current and
Externí odkaz:
https://doaj.org/article/696a47b9bd404f98a5cb348432580fe7
Autor:
Jamie E Meegan, Ciara M Shaver, Nathan D Putz, Jordan J Jesse, Stuart R Landstreet, Han Noo Ri Lee, Tatiana N Sidorova, J Brennan McNeil, James L Wynn, Joyce Cheung-Flynn, Padmini Komalavilas, Colleen M Brophy, Lorraine B Ware, Julie A Bastarache
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228727 (2020)
Increased endothelial permeability is central to the pathogenesis of sepsis and leads to organ dysfunction and death but the endogenous mechanisms that drive increased endothelial permeability are not completely understood. We previously reported tha
Externí odkaz:
https://doaj.org/article/e068d1cb04d84396b01306e30f41f480
Autor:
Sarah J Atkinson, Brian M Varisco, Mary Sandquist, Meghan N Daly, Lindsey Klingbeil, Joshua W Kuethe, Emily F Midura, Kelli Harmon, Amy Opoka, Patrick Lahni, Giovanna Piraino, Paul Hake, Basilia Zingarelli, Joel E Mortensen, James L Wynn, Hector R Wong
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 455-463 (2016)
Abstract Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8 (MMP8) improves survival in an adult murine sepsis model. Because developmental age influences the host inflammatory response, we hypothesized that developmental age
Externí odkaz:
https://doaj.org/article/bb6ee77a25884b63ba7c9179b3e415c4
Autor:
Joseph M. Bliss, James L. Wynn
Publikováno v:
Frontiers in Pediatrics, Vol 5 (2017)
Externí odkaz:
https://doaj.org/article/b2d7dcabc02e434ab32187be7565ef0e
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Essentially, all neonates are exposed to infections, antibiotics, or vaccines early in their lives. This is especially true for those neonates born underweight or premature. In contrast to septic adults and children who are at an increased risk for s
Externí odkaz:
https://doaj.org/article/a1a6d5c46c714a619c8fedd721edbf41
Autor:
Steven L Raymond, María Cecilia López, Henry V Baker, Shawn D Larson, Philip A Efron, Timothy E Sweeney, Purvesh Khatri, Lyle L Moldawer, James L Wynn
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184159 (2017)
Sepsis is a major cause of morbidity and mortality, especially at the extremes of age. To understand the human age-specific transcriptomic response to sepsis, a multi-cohort, pooled analysis was conducted on adults, children, infants, and neonates wi
Externí odkaz:
https://doaj.org/article/96358a27d07b4d0daa06eb06cfd3829a
Autor:
Ruth Ann Veach, Yan Liu, Jozef Zienkiewicz, Lukasz S Wylezinski, Kelli L Boyd, James L Wynn, Jacek Hawiger
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179468 (2017)
The rising tide of sepsis, a leading cause of death in the US and globally, is not adequately controlled by current antimicrobial therapies and supportive measures, thereby requiring new adjunctive treatments. Severe microvascular injury and multiple
Externí odkaz:
https://doaj.org/article/6ce763e49e40418ab33a884dc0abb633
Autor:
Colin Ratledge, James P. Wynn
Publikováno v:
Microbiology (Reading, England). 143(1)
Malic enzyme was shown to be a major source of NADPH for the synthesis of storage lipid by Aspergillus nidulans. A previously produced mutant lacking malic enzyme activity (acuK248) accumulated only half the lipid (12%, w/w, of cell dry weight) accum