Zobrazeno 1 - 10
of 13
pro vyhledávání: '"James P. Woodgett"'
Autor:
Zhe Jiang, YoungJun Ju, Amjad Ali, Philip E. D. Chung, Patryk Skowron, Dong-Yu Wang, Mariusz Shrestha, Huiqin Li, Jeff C. Liu, Ioulia Vorobieva, Ronak Ghanbari-Azarnier, Ethel Mwewa, Marianne Koritzinsky, Yaacov Ben-David, James R. Woodgett, Charles M. Perou, Adam Dupuy, Gary D. Bader, Sean E. Egan, Michael D. Taylor, Eldad Zacksenhaus
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship between oncogenic drivers that promote metastatic versus primary cancer is still contentious. To elucidate this relationship in treatment-naive anima
Externí odkaz:
https://doaj.org/article/141fc3ada18346a59e6af3fd9ea5bbbb
Autor:
Aeen Ebrahim Amini, Tsukiko Miyata, Gang Lei, Fuzi Jin, Elizabeth Rubie, Clarrisa A. Bradley, James R. Woodgett, Graham L. Collingridge, John Georgiou
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Glycogen synthase kinase-3 (GSK3) mediates phosphorylation of several hundred proteins, and its aberrant activity is associated with an array of prevalent disorders. The two paralogs, GSK3α and GSK3β, are expressed ubiquitously and fulfill common a
Externí odkaz:
https://doaj.org/article/f810d1a6561e4cd399ff5c0972d0106d
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-13 (2019)
Abstract Background Triple-negative breast cancer (TNBC) represents a heterogeneous group of ER- and HER2-negative tumors with poor clinical outcome. We recently reported that Pten-loss cooperates with low expression of microRNA-145 to induce aggress
Externí odkaz:
https://doaj.org/article/42ae3dadb74d451680d33c46a7721892
Autor:
Junyu Li, Shanshan Ma, Jingnan Chen, Kunhua Hu, Yongyi Li, Zeyu Zhang, Zixiang Su, James R. Woodgett, Mingtao Li, Qiaoying Huang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Glycogen synthase kinase-3 (GSK-3) dysregulation has been implicated in nigral dopaminergic neurodegeneration, one of the main pathological features of Parkinson’s disease (PD). The two isoforms, GSK-3α and GSK-3β, have both been suggested to pla
Externí odkaz:
https://doaj.org/article/06770337c211464ba5568809d7272a20
Autor:
Jeff C. Liu, Letizia Granieri, Mariusz Shrestha, Dong-Yu Wang, Ioulia Vorobieva, Elizabeth A. Rubie, Rob Jones, YoungJun Ju, Giovanna Pellecchia, Zhe Jiang, Carlo A. Palmerini, Yaacov Ben-David, Sean E. Egan, James R. Woodgett, Gary D. Bader, Alessandro Datti, Eldad Zacksenhaus
Publikováno v:
Cell Reports, Vol 23, Iss 1, Pp 112-126 (2018)
Summary: CDK4/6 inhibitors are effective against cancer cells expressing the tumor suppressor RB1, but not RB1-deficient cells, posing the challenge of how to target RB1 loss. In triple-negative breast cancer (TNBC), RB1 and PTEN are frequently inact
Externí odkaz:
https://doaj.org/article/2f8dda134cd247b39c4432a3f20e70bd
Autor:
Kevin W. Cormier, James R. Woodgett
Publikováno v:
F1000Research, Vol 6 (2017)
Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed protein kinase that sits at the nexus of multiple signaling pathways. Its deep integration into cellular control circuits is consummate to its implication in diseases ranging from mood di
Externí odkaz:
https://doaj.org/article/81db5584b1564e16a5d0526da00589b0
Autor:
Nigel Kurgan, Kennedy C. Whitley, Lucas A. Maddalena, Fereshteh Moradi, Joshua Stoikos, Sophie I. Hamstra, Elizabeth A. Rubie, Megha Kumar, Brian D. Roy, James R. Woodgett, Jeffrey A. Stuart, Val A. Fajardo
Publikováno v:
Cells, Vol 8, Iss 11, p 1340 (2019)
Glycogen synthase kinase 3 (GSK3) slows myogenic differentiation and myoblast fusion partly by inhibiting the Wnt/β-catenin signaling pathway. Lithium, a common medication for bipolar disorder, inhibits GSK3 via Mg+ competition and increased Ser21 (
Externí odkaz:
https://doaj.org/article/dc36e0636c20424e8b1944f2b723ce52
Autor:
Tamara Holowacz, Tania O. Alexson, Brenda L. Coles, Bradley W. Doble, Kevin F. Kelly, James R. Woodgett, Derek Van Der Kooy
Publikováno v:
Biology Open, Vol 2, Iss 8, Pp 812-821 (2013)
Summary Neural stem cells (NSCs) can be obtained from a variety of sources, but not all NSCs exhibit the same characteristics. We have examined how the level of glycogen synthase kinase-3 activity regulates NSCs obtained from different sources: the m
Externí odkaz:
https://doaj.org/article/263313ab26584e0096e78d0970aa3343
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 5 (2012)
Externí odkaz:
https://doaj.org/article/3c105aae215b496cb01b54bc082cd53c
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15845 (2011)
Over-activity and elevated expression of glycogen synthase kinase-3 (GSK-3) has been implicated in the etiology of insulin resistance and Type 2 diabetes. Administration of specific GSK-3 inhibitors to diabetic or obese rodent models improves glycaem
Externí odkaz:
https://doaj.org/article/2ddb5f7c9dda4e67af6605647de1a933