Zobrazeno 1 - 8
of 8
pro vyhledávání: '"James P. Villa"'
Publikováno v:
Journal of Biological Chemistry. 278:42545-42550
The protease domains of the evolutionarily related alpha and beta subunits of meprin metalloproteases are approximately 55% identical at the amino acid level; however, their substrate and peptide bond specificities differ markedly. The meprin beta su
Publikováno v:
Biochemical Society Symposia. 70:53-63
Meprins are metalloproteinases of the astacin family and metzincin superfamily that are composed of evolutionarily related alpha and beta subunits, which exist as homo- and hetero-oligomeric complexes. These complexes are abundant at the brush border
Autor:
James P. Villa, Kang Yan, Angela Smallwood, Khyati Oza, Robert B. Kirkpatrick, Jessica L. Schneck, Sara H. Thrall, Baoguang Zhao, Patrick McDevitt, Jacques Briand, Stephanie Chen, Ruth Lehr, Nestor O. Concha, Thomas D. Meek
Publikováno v:
Biochemistry. 49(33)
Steady-state kinetic analysis of focal adhesion kinase-1 (FAK1) was performed using radiometric measurement of phosphorylation of a synthetic peptide substrate (Ac-RRRRRRSETDDYAEIID-NH(2), FAK-tide) which corresponds to the sequence of an autophospho
Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode
Autor:
Jessica L. Schneck, Brian Dombroski, Michael D. Wall, Chris J. Delves, Stuart P. Ballantine, James P. Villa, Jeffrey W. Gross, Afjal Hussain Miah, Michael Kranz, Don O. Somers, Brian Evans, Margarete Neu
Publikováno v:
Bioorganicmedicinal chemistry. 17(14)
A PDE4B over 4D-selective inhibitor programme was initiated to capitalise on the recently discovered predominance of the PDE4B subtype in inflammatory cell regulation. The SAR of a tetrahydrobenzothiophene (THBT) series did not agree with either of t
Autor:
Michael S. McQueney, Thomas D. Meek, James P. Villa, Patrick McDevitt, Jessica L. Schneck, Sara H. Thrall
Publikováno v:
Biochemistry. 47(33)
Cathepsin C, or dipeptidyl peptidase I, is a lysosomal cysteine protease of the papain family that catalyzes the sequential removal of dipeptides from the free N-termini of proteins and peptides. Using the dipeptide substrate Ser-Tyr-AMC, cathepsin C
Publikováno v:
Biological chemistry. 383(7-8)
A conserved tyrosine residue in the astacin family of metalloproteases is one of five ligands proposed to coordinate zinc at the active site. Sitedirected mutagenesis of the conserved Tyr (Y226) of recombinant mouse meprin α was used to test the hyp
Publikováno v:
Biological chemistry. 383(7-8)
Meprin A and B are highly regulated, secreted and cell-surface homo- and hetero-oligomeric enzymes. Meprins are abundantly expressed in kidney and intestine. The multidomain alpha and beta subunits have high sequence identity, however they have very
Autor:
Richard Wooster, Kristin K. Brown, Deping Chai, Mariela Colón, Jennifer L. Ariazi, Chad Quinn, Sharon Sweitzer, Nino Campobasso, Subhas J. Chakravorty, Gregory M. Waitt, Tony Shaw, Kevin J. Duffy, Roland S. Annan, Jacques Briand, Nathan Gaul, Christian S. Sherk, Elizabeth A. Davenport, Jeanelle McSurdy-Freed, Kelvin Nurse, Anthony J. Jurewicz, Dean E. McNulty, Gilbert F. Scott, Angela Smallwood, James P. Villa, Hong Lu, Paru Nuthulaganti, Julia Billiard, Christopher S Dodson, Jessica L. Schneck, Lisa Miller, Seth A. Gilbert
Publikováno v:
Cancer Research. 73:5418-5418
Many cancer cells generate energy by rapidly converting glucose to lactate in the cytosol, a process termed aerobic glycolysis. This metabolic phenotype is recognized as one of the hallmarks of cancer and is enabled by lactate dehydrogenase (LDH), wh