Výsledky vyhledávání - "James P. Schavocky"

Akademický článek

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.

Autor: D Martin Watterson, Valerie L Grum-Tokars, Saktimayee M Roy, James P Schavocky, Brinda Desai Bradaric, Adam D Bachstetter, Bin Xing, Edgardo Dimayuga, Faisal Saeed, Hong Zhang, Agnieszka Staniszewski, Jeffrey C Pelletier, George Minasov, Wayne F Anderson, Ottavio Arancio, Linda J Van Eldik

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e66226 (2013)

Serine-threonine protein kinases are critical to CNS function, yet there is a dearth of highly selective, CNS-active kinase inhibitors for in vivo investigations. Further, prevailing assumptions raise concerns about whether single kinase inhibitors c

Externí odkaz: https://doaj.org/article/b2d92bb12d1e444bacfe050f97863231

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Phosphorylation Regulates Interaction of 210-kDa Myosin Light Chain Kinase N-terminal Domain with Actin Cytoskeleton

Autor: D. M. Watterson, A. V. Nikashin, Asker Y. Khapchaev, Thomas J. Lukas, Vladimir P. Shirinsky, Elena L. Vilitkevich, James P. Schavocky, Dmitri S. Kudryashov

Publikováno v: Biochemistry. Biokhimiia. 80(10)

High molecular weight myosin light chain kinase (MLCK210) is a multifunctional protein involved in myosin II activation and integration of cytoskeletal components in cells. MLCK210 possesses actin-binding regions both in the central part of the molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2452d47f4c865947d3fbeff2a2edbd14
https://pubmed.ncbi.nlm.nih.gov/26567572

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Protein kinase involved in lung injury susceptibility: Evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment

Autor: David M. Steinhorn, Yuzhi Jia, D. Martin Watterson, Janet L. Rossi, Linda J. Van Eldik, James P. Schavocky, Susan E. Crawford, Magdalena Zasadzki, Vladimir P. Shirinsky, Mark S. Wainwright, Jacques Haiech, Anastasia Velentza

Publikováno v: Proceedings of the National Academy of Sciences. 100:6233-6238

Acute lung injury (ALI) associated with sepsis and iatrogenic ventilator-induced lung injury resulting from mechanical ventilation are major medical problems with an unmet need for small molecule therapeutics. Prevailing hypotheses identify endotheli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b91ac6c1eea98a26bf0a2c96b9058a
https://doi.org/10.1073/pnas.1031595100

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Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: Organization, expression, alternative splicing, and polymorphic marker

Autor: Jacques Haiech, Linda J. Van Eldik, Vladimir P. Shirinsky, D. Martin Watterson, Alexandre Chlenski, James P. Schavocky, Curtis H. Weiss, Ling Guo

Publikováno v: Journal of Cellular Biochemistry. 75:481-491

We report the amino acid sequence, genomic organization, tissue expression, and alternative splice patterns for the human kinase related protein (KRP) gene, as well as the discovery of a new CA repeat sequence polymorphic marker in an upstream intron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68a437482e249862439f78697cfcfe30
https://doi.org/10.1002/(sici)1097-4644(19991201)75:3<481::aid-jcb12>3.0.co

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Organization of the genetic locus for chicken myosin light chain kinase is complex: Multiple proteins are encoded and exhibit differential expression and localization

Autor: Konstantin G. Birukov, Margarita V. Chibalina, Linda J. Van Eldik, James P. Schavocky, D. Martin Watterson, Vladimir P. Shirinsky

Publikováno v: Journal of Cellular Biochemistry. 70:402-413

We report that the genetic locus that encodes vertebrate smooth muscle and nonmuscle myosin light chain kinase (MLCK) and kinase-related protein (KRP) has a complex arrangement and a complex pattern of expression. Three proteins are encoded by 31 exo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::faa41ebdbe8d6c57472103c63412221e
https://doi.org/10.1002/(sici)1097-4644(19980901)70:3<402::aid-jcb13>3.0.co

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Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

Autor: Faisal Saeed, Agnieszka Staniszewski, Bin Xing, Jeffrey C. Pelletier, Saktimayee M. Roy, James P. Schavocky, Adam D. Bachstetter, Ottavio Arancio, Valerie Grum-Tokars, Linda J. Van Eldik, Wayne F. Anderson, George Minasov, Brinda Desai Bradaric, Hong Zhang, D. Martin Watterson, Edgardo Dimayuga

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e66226 (2013)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ecb22da6830ee0fe705b176f9070e7
http://europepmc.org/articles/PMC3694096?pdf=render

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A calmodulin-regulated protein kinase linked to neuron survival is a substrate for the calmodulin-regulated death-associated protein kinase

Autor: Andrew M. Schumacher, Anastasia Velentza, D. Martin Watterson, James P. Schavocky, Salida Mirzoeva

Publikováno v: Biochemistry. 43(25)

Death-associated protein kinase (DAPK) is a calmodulin (CaM)-regulated protein kinase and a drug-discovery target for neurodegenerative diseases. However, a protein substrate relevant to neuronal death had not been described. We identified human brai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df048cd0fcd9dca8a24aaccce17646d
https://pubmed.ncbi.nlm.nih.gov/15209507

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Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB

Autor: Linda J. Van Eldik, Jeffrey M. Craft, James P. Schavocky, D. Martin Watterson, Ling Guo, Tanuja Koppal, Amy G.M Lam, Keith T. Akama, Barat Samy

Publikováno v: Neurobiology of aging. 22(5)

Compelling evidence links chronic activation of glia and the subsequent cycle of neuroinflammation and neuronal dysfunction to the progression of neurodegeneration in disorders such as Alzheimer's disease (AD). S100B, a glial-derived cytokine, is sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa385c78fd67430ac080fb30ee20786
https://pubmed.ncbi.nlm.nih.gov/11705636

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