Zobrazeno 1 - 10
of 96
pro vyhledávání: '"James P. O'Gara"'
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
The pervasive presence of Staphylococcus epidermidis and other coagulase-negative staphylococci on the skin and mucous membranes has long underpinned a casual disregard for the infection risk that these organisms pose to vulnerable patients in health
Externí odkaz:
https://doaj.org/article/a1facafd2bfc482ca09411f54b4ff306
Autor:
Aaron C. Nolan, Merve S. Zeden, Igor Kviatkovski, Christopher Campbell, Lucy Urwin, Rebecca M. Corrigan, Angelika Gründling, James P. O’Gara
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT The purine-derived signaling molecules c-di-AMP and (p)ppGpp control mecA/PBP2a-mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise the possibility that purine availability can control antibiotic suscept
Externí odkaz:
https://doaj.org/article/2569cc018a4a45ce9352186973795a76
Autor:
Christopher Campbell, Claire Fingleton, Merve S. Zeden, Emilio Bueno, Laura A. Gallagher, Dhananjay Shinde, Jongsam Ahn, Heather M. Olson, Thomas L. Fillmore, Joshua N. Adkins, Fareha Razvi, Kenneth W. Bayles, Paul D. Fey, Vinai C. Thomas, Felipe Cava, Geremy C. Clair, James P. O’Gara
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
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Externí odkaz:
https://doaj.org/article/e4f0ec57fff44791bcf41bfd3a0e63ec
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2465 (2020)
The biofilm component poly-N-acetylglucosamine (PNAG) is an important virulence determinant in medical-device-related infections caused by ESKAPE group pathogens including Gram-positive Staphylococcus aureus and Gram-negative Acinetobacter baumannii.
Externí odkaz:
https://doaj.org/article/ff5ed824697c4fc2afd5a7c097d1a528
Autor:
Matthias Tacke, Bettina Schaible, Siddappa Patil, Francesca Paradisi, Frauke Hackenberg, Claire Healy, Stephen V. Gordon, Michael A. Sharkey, James P. O'Gara
Publikováno v:
Antibiotics, Vol 1, Iss 1, Pp 25-28 (2012)
The synthesis of N-heterocyclic carbene (NHC) silver(I) acetate complexes with varying lipophilic benzyl-substituents at the 1 and 3 positions starting from 4,5-diphenylimidazole, opened a new class of antibiotic drug candidates. These NHC-silver(I)
Externí odkaz:
https://doaj.org/article/ba20f40b98bd43dd8792d3d10631e3dd
Autor:
Hannah eMcCarthy, Justine K. Rudkin, Nikki S. Black, Laura eGallagher, Eoghan eO'Neill, James P. O'Gara
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 5 (2015)
Antibiotic resistance and biofilm-forming capacity contribute to the success of Staphylococcus aureus as a human pathogen in both healthcare and community settings. These virulence factors do not function independently of each other and the biofilm p
Externí odkaz:
https://doaj.org/article/63d02608c45947819ad0c09558735280
Autor:
Merve S. Zeden, Laura A. Gallagher, Emilio Bueno, Aaron C. Nolan, Jongsam Ahn, Dhananjay Shinde, Fareha Razvi, Margaret Sladek, Órla Burke, Eoghan O’Neill, Paul D. Fey, Felipe Cava, Vinai C. Thomas, James P. O’Gara
Central metabolic pathways controls virulence and antibiotic resistance, and constitute potential targets for antibacterial drugs. InStaphylococcus aureusthe role of the pentose phosphate pathway (PPP) remains largely unexplored. Mutation of the 6-ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d69b2067bd3684fcaab5fea560772c4
https://doi.org/10.1101/2023.03.03.530734
https://doi.org/10.1101/2023.03.03.530734
Publikováno v:
International Journal of Nanomedicine. 15:4779-4791
Background: Considering the timeline required for the development of novel antimicrobial drugs, increased attention should be given to repurposing old drugs and improving antimicrobial efficacy, particularly for chronic infections associated with bio
Autor:
Jongsam Ahn, Felipe Cava, James P. O'Gara, Joshua N. Adkins, Emilio Bueno, Kenneth W. Bayles, Claire Fingleton, Fareha Razvi, Paul D. Fey, Dhananjay Shinde, Merve Suzan Zeden, Christopher Campbell, Geremy Clair, Vinai Chittezham Thomas, Laura A. Gallagher, Heather M. Olson, Thomas L. Fillmore
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Penicillin binding protein 2a (PBP2a)-dependent resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is regulated by the activity of the tricarboxylic acid (TCA) cycle via a poorly understood mechanism. We report
Publikováno v:
HRB open research. 4
Introduction: Wound healing is characterised by haemostatic, inflammatory, proliferative and remodelling phases. In the presence of comorbidities such as diabetes, healing can stall and chronic wounds may result. Infection is detrimental to these wou