Zobrazeno 1 - 10
of 22
pro vyhledávání: '"James P. Loehr"'
Autor:
Lathan Lucas, Larissa Nitschke, Brandon Nguyen, James A. Loehr, George G. Rodney, Thomas A. Cooper
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111104- (2024)
Summary: Skeletal muscle cells (myofibers) are elongated non-mitotic, multinucleated syncytia that have adapted a microtubule lattice. Microtubule-associated proteins (MAPs) play roles in regulating microtubule architecture. The most abundant MAP in
Externí odkaz:
https://doaj.org/article/b97167ad0f6049e7a56278c345d0f1e0
Autor:
James Anthony Loehr, Shang Wang, Tanya R Cully, Rituraj Pal, Irina V Larina, Kirill V Larin, George G Rodney
Publikováno v:
eLife, Vol 11 (2022)
Externí odkaz:
https://doaj.org/article/0d8404561d0645fdad5e36648483aa2f
Autor:
James Anthony Loehr, Shang Wang, Tanya R Cully, Rituraj Pal, Irina V Larina, Kirill V Larin, George G Rodney
Publikováno v:
eLife, Vol 7 (2018)
Skeletal muscle from mdx mice is characterized by increased Nox2 ROS, altered microtubule network, increased muscle stiffness, and decreased muscle/respiratory function. While microtubule de-tyrosination has been suggested to increase stiffness and N
Externí odkaz:
https://doaj.org/article/9e36ae2446184f9694041650fe83a4b8
Autor:
Amy E Brinegar, Zheng Xia, James Anthony Loehr, Wei Li, George Gerald Rodney, Thomas A Cooper
Publikováno v:
eLife, Vol 6 (2017)
Postnatal development of skeletal muscle is a highly dynamic period of tissue remodeling. Here, we used RNA-seq to identify transcriptome changes from late embryonic to adult mouse muscle and demonstrate that alternative splicing developmental transi
Externí odkaz:
https://doaj.org/article/937ae9dfce8f43faa857a4d762c05add
Publikováno v:
Frontiers in Physiology, Vol 5 (2015)
Elevated concentrations of sphingomyelinase (SMase) have been detected in a variety of diseases. SMase has been shown to increase muscle derived oxidants and decrease skeletal muscle force; however, the sub-cellular site of oxidant production has not
Externí odkaz:
https://doaj.org/article/432a746055a44c21b0acb19b41f726c9
Autor:
Katherine P. Ponder, Elizabeth A. Braunlin, Howard M. Rosenfeld, Beatriz Furlanetto, Christoph Kampmann, Roberto Giugliani, William C. Roberts, James P. Loehr, Paul Harmatz, Maurizio Scarpa
Publikováno v:
Journal of inherited metabolic disease, vol 34, iss 6
Journal of Inherited Metabolic Disease
Journal of Inherited Metabolic Disease
The mucopolysaccharidoses (MPSs) are inherited lysosomal storage disorders caused by the absence of functional enzymes that contribute to the degradation of glycosaminoglycans (GAGs). The progressive systemic deposition of GAGs results in multi-organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5279bd790093eb2ca34967c7edca202
https://doi.org/10.1007/s10545-011-9359-8
https://doi.org/10.1007/s10545-011-9359-8
Publikováno v:
Birth Defects Research Part A: Clinical and Molecular Teratology. 79:309-316
BACKGROUND: As part of an effort to validate the General Practice Research Database (GPRD) for future studies of medication use in pregnancy, this study examined whether the rates of all, and specific types of, congenital heart defects obtained from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91c7b28a7270e4c7268b07b11a9a80b
https://doi.org/10.1002/bdra.20356
https://doi.org/10.1002/bdra.20356
Publikováno v:
Pharmacoepidemiology and Drug Safety. 16:867-877
Objective The purpose of this research was (1) to validate that ventricular septal defect (VSD), tetralogy of Fallot (TOF), and coarctation of the aorta (COA) can be studied in the UK General practice research database (GPRD) and (2) to understand wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376e65e3d13b764f925542b50cdc5c23
https://doi.org/10.1002/pds.1431
https://doi.org/10.1002/pds.1431
Publikováno v:
Gastroenterology. 105:178-187
Background: Dietary copper overload in the rat is associated with morphological abnormalities and lipid peroxidation of hepatic mitochondria. This study was designed to determine if copper hepatotoxicity was associated with functional alterations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a814add9254bffd3d1b91090675951c5
https://doi.org/10.1016/0016-5085(93)90024-7
https://doi.org/10.1016/0016-5085(93)90024-7
Publikováno v:
The Journal of pediatrics. 159(2)
To assess the prevalence of cardiovascular signs and symptoms in a large group of patients with Hunter syndrome, an X-linked metabolic disorder caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase.The Hunter Outcome Survey was establi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c35e5a35a8eea90cd8eb71562260ff2
https://pubmed.ncbi.nlm.nih.gov/21529823
https://pubmed.ncbi.nlm.nih.gov/21529823