Zobrazeno 1 - 10
of 143
pro vyhledávání: '"James P. Kushner"'
Publikováno v:
Blood Cells, Molecules, and Diseases. 47:249-254
Cytochrome P4501A2 (Cyp1a2) is important in the development of uroporphyria in mice, a model of porphyria cutanea tarda in humans. Heretofore, mice homozygous for the Cyp1a2−/− mutation do not develop uroporphyria with treatment regimens that res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed29579c9d7e30777661cdc5b797da93
https://doi.org/10.1016/j.bcmd.2011.07.006
https://doi.org/10.1016/j.bcmd.2011.07.006
Publikováno v:
Obesity. 22:2120-2122
Objective Levels of tissue iron contribute to determining diabetes risk, but little is known about the effects of higher iron levels on weight, and on the interaction of weight and iron overload on diabetes risk. Therefore, the effect of iron on body
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b6001610e8ed0f1110c7919d8a02fb9
https://doi.org/10.1002/oby.20839
https://doi.org/10.1002/oby.20839
Autor:
James P. Kushner, Mark L. Westbroek, Michael R. Franklin, Dorinda D Arch, Laura B. Hathaway, John D. Phillips, Melissa L. Barker
Publikováno v:
Chemico-Biological Interactions. 182:220-226
The response of hepatic mono-oxygenase activities to Aroclor 1254 or 3-methylcholanthrene was investigated in wild-type and Cyp1a2(-/-) mice. Cytochrome P450 concentrations were similar in naive Cyp1a2(-/-) and wild-type mice. There was no difference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16a48820335a6186f75d98ba612b60b
https://doi.org/10.1016/j.cbi.2009.09.007
https://doi.org/10.1016/j.cbi.2009.09.007
Autor:
James P. Kushner, Richard S. Ajioka, Sean Proll, Diane M. Dunn, Maria W. Smit, John D. Phillips, Robert B. Weiss, Michael G. Katze
Publikováno v:
Blood. 112:4723-4728
Hepatic siderosis is common in patients with porphyria cutanea tarda (PCT). Mutations in the hereditary hemochromatosis (hh) gene (HFE) explain the siderosis in approximately 20% patients, suggesting that the remaining occurrences result from additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fff17f82ef2ff483200671f873bb8a
https://doi.org/10.1182/blood-2008-02-138222
https://doi.org/10.1182/blood-2008-02-138222
Autor:
Donald A. McClain, J. Scott Gabrielsen, Bai Luo, Mark Hazel, James P. Kushner, Yudi Soesanto, Robert C. Cooksey, Laszlo G. Boros, Lauren Knecht, Deborah Jones, Hani A. Jouihan, Jingyu Huang
Publikováno v:
Journal of Biological Chemistry. 282:37501-37507
Hereditary hemochromatosis is an inherited disorder of increased iron absorption that can result in cirrhosis, diabetes, and other morbidities. We have investigated the mechanisms underlying supranormal glucose tolerance despite decreased insulin sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd307fa392fb54e7b5e43f659b503f7
https://doi.org/10.1074/jbc.m703625200
https://doi.org/10.1074/jbc.m703625200
Autor:
Venkatesh K. Rudrapatna, Kenneth M. Boucher, Kimberly A. Morley, Andrew S. Pierson, James P. Kushner, Paul J. Shami, Christian T. Shull
Publikováno v:
Leukemia research. 39(8)
We investigated protracted low-dose oral Clofarabine for the treatment of myelodysplastic syndromes (MDS). Adults with an International Prognostic Scoring System (IPSS) score of INT-1 or higher who had failed first line therapy were eligible. INT-1 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a019dc2fe605e6a5cc30616d50b6edb4
https://pubmed.ncbi.nlm.nih.gov/26038120
https://pubmed.ncbi.nlm.nih.gov/26038120
Publikováno v:
Clinical biochemistry. 48(12)
In mammalian cells the rate-limiting step in heme biosynthesis is the formation of δ-aminolevulinic acid (ALA). The reaction intermediates, porphyrins and iron and the final product, heme can be highly cytotoxic if allowed to accumulate. The importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d51f44de5dee703cafb1bed0fc8b1c
https://pubmed.ncbi.nlm.nih.gov/25959086
https://pubmed.ncbi.nlm.nih.gov/25959086
Publikováno v:
Diabetologia. 49:2546-2551
We recently demonstrated that humans with hereditary haemochromatosis have decreased insulin secretory capacity with a compensatory increase in insulin sensitivity. We therefore determined how these measures change after correction of tissue iron ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d80dcd207b5e789951851167681977
https://doi.org/10.1007/s00125-006-0445-7
https://doi.org/10.1007/s00125-006-0445-7
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1763:723-736
Most iron in mammalian systems is routed to mitochondria to serve as a substrate for ferrochelatase. Ferrochelatase inserts iron into protoporphyrin IX to form heme which is incorporated into hemoglobin and cytochromes, the dominant hemoproteins in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d8da1c3e9c227e54b6a5a3e542dfe4e
https://doi.org/10.1016/j.bbamcr.2006.05.005
https://doi.org/10.1016/j.bbamcr.2006.05.005
Autor:
Richard S. Ajioka, Devaprabu Abraham, Jack T. Rogers, R. Brady, Donald A. McClain, James P. Kushner, P. Gault
Publikováno v:
Diabetologia. 49:1661-1669
The prevalence and mechanisms of diabetes in hereditary haemochromatosis are not known. We therefore measured glucose tolerance, insulin secretory capacity and insulin sensitivity in adults with haemochromatosis.Subjects recruited from referrals to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ad570581ff10b1d5667310ed7d4112
https://doi.org/10.1007/s00125-006-0200-0
https://doi.org/10.1007/s00125-006-0200-0