Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo

Autor: Eleri A. Ashworth, Rosanna C. T. Wright, Rebecca K. Shears, Janet K. L. Wong, Akram Hassan, James P. J. Hall, Aras Kadioglu, Joanne L. Fothergill

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Pseudomonas aeruginosa is a major nosocomial pathogen that causes severe disease including sepsis. Carbapenem-resistant P. aeruginosa is recognised by the World Health Organisation as a priority 1 pathogen, with urgent need for new therapeut

Externí odkaz: https://doaj.org/article/d7674a4d2b9846549863382aa65c4b86

A megaplasmid family driving dissemination of multidrug resistance in Pseudomonas

Autor: Adrian Cazares, Matthew P. Moore, James P. J. Hall, Laura L. Wright, Macauley Grimes, Jean-Guillaume Emond-Rhéault, Pisut Pongchaikul, Pitak Santanirand, Roger C. Levesque, Joanne L. Fothergill, Craig Winstanley

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

The emergence of multidrug resistance (MDR) in bacteria represents a global threat to human health. Here, Cazares et al. identify a family of MDR megaplasmids carrying large arrays of antibiotic resistance genes in Pseudomonas strains from various so

Externí odkaz: https://doaj.org/article/b3e3a6e492364cb59fec9c6d1a7c089f

The Impact of Mercury Selection and Conjugative Genetic Elements on Community Structure and Resistance Gene Transfer

Autor: James P. J. Hall, Ellie Harrison, Katariina Pärnänen, Marko Virta, Michael A. Brockhurst

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

Carriage of resistance genes can underpin bacterial survival, and by spreading these genes between species, mobile genetic elements (MGEs) can potentially protect diversity within microbial communities. The spread of MGEs could be affected by environ

Externí odkaz: https://doaj.org/article/d52d594256e1467584b2b13bae1fbc62

Compensatory mutations reducing the fitness cost of plasmid carriage occur in plant rhizosphere communities

Autor: Susannah M Bird, Samuel Ford, Catriona M A Thompson, Richard Little, James P J Hall, Robert W Jackson, Jacob Malone, Ellie Harrison, Michael A Brockhurst

Publikováno v: Bird, S M, Ford, S, Thompson, C M A, Little, R H, Hall, J P J, Jackson, R W, Malone, J, Harrison, E & Brockhurst, M 2023, ' Compensatory mutations reducing the fitness cost of plasmid carriage occur in plant rhizosphere communities ', FEMS Microbiology Ecology . https://doi.org/10.1093/femsec/fiad027

Plasmids drive bacterial evolutionary innovation by transferring ecologically important functions between lineages, but acquiring a plasmid often comes at a fitness cost to the host cell. Compensatory mutations, which ameliorate the cost of plasmid c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bbed38f5c6278bd6951111056b1b85
https://doi.org/10.1093/femsec/fiad027

Plasmid manipulation of bacterial behaviour through translational regulatory crosstalk

Autor: Catriona M A Thompson, James P. J. Hall, Govind Chandra, Carlo Martins, Gerhard Saalbach, Susannah Bird, Samuel Ford, Richard H. Little, Ainelen Piazza, Ellie Harrison, Robert W. Jackson, Michael A. Brockhurst, Jacob G. Malone

Beyond their role in horizontal gene transfer, conjugative plasmids commonly encode homologues of bacterial regulators. Known plasmid regulator homologues have highly targeted effects upon the transcription of specific bacterial traits. Here, we char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe210ae6567979b53f8849534da8f687
https://doi.org/10.1101/2022.06.27.497698