Zobrazeno 1 - 8
of 8
pro vyhledávání: '"James P. Flinn"'
Publikováno v:
Scopus-Elsevier
We report here the synthesis of iberiotoxin (IbTX), a 37-amino acid peptide containing three disulfide bridges, and a series of mono-looped analogues. All syntheses were conducted using Fmoc chemistry. Synthesis of IbTX gave a product which was indis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc69eb1e1dae9ff77eeb73c89eab6b9
https://doi.org/10.1111/j.1399-3011.1995.tb01044.x
https://doi.org/10.1111/j.1399-3011.1995.tb01044.x
Autor:
James A. Angus, Raymond S. Norton, Paul K. Pallaghy, Michael J. Lew, James P. Flinn, Roger Murphy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1434:177-190
ω-Conotoxin GVIA (GVIA), an N-type calcium channel blocker from the cone shell Conus geographus , is a 27 residue polypeptide cross-linked by three disulfide bonds. Here, we report the synthesis, structural analysis by 1 H NMR and bioassay of analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e1a6d3ac9c09aff3a72433c731a9e9
https://doi.org/10.1016/s0167-4838(99)00165-x
https://doi.org/10.1016/s0167-4838(99)00165-x
Autor:
Paul K. Pallaghy, James A. Angus, James P. Flinn, Raymond S. Norton, Sarah L. Whorlow, Roger Murphy, Christine E. Wright, Michael J. Lew
Publikováno v:
Journal of Biological Chemistry. 272:12014-12023
The structure-function relationships of the N-type calcium channel blocker, ω-conotoxin GVIA (GVIA), have been elucidated by structural, binding and in vitro and in vivo functional studies of alanine-substituted analogues of the native molecule. Ala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06bb11fdd07cb038a7b7d4dfbdf6859e
https://doi.org/10.1074/jbc.272.18.12014
https://doi.org/10.1074/jbc.272.18.12014
Autor:
James P. Flinn, Roger Murphy
Publikováno v:
Letters in Peptide Science. 3:113-116
We have shown that the yield of native ω-conotoxin GVIA after dimethylsulphoxide-mediated oxidative refolding of a synthetic, linear precursor is highly dependant upon the choice of refolding buffer and peptide concentration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::924d64a8893e5d19835744256f5dcde7
https://doi.org/10.1007/bf00132972
https://doi.org/10.1007/bf00132972
Autor:
Paul K. Pallaghy, Michael J. Lew, Roger Murphy, Raymond S. Norton, James A. Angus, James P. Flinn
Publikováno v:
European journal of biochemistry. 262(2)
The contributions of various functional groups to the pharmacophore of the N-type calcium-channel blocker, omega-conotoxin GVIA (GVIA), have been investigated using structural and in-vitro functional studies of analogues substituted at one or two pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4dc8036abe5a9677bb4ccdc5fb50c8
https://pubmed.ncbi.nlm.nih.gov/10336629
https://pubmed.ncbi.nlm.nih.gov/10336629
Autor:
James P. Flinn, Christine E. Wright, Roger Murphy, James A. Angus, Michael J. Lew, Boublik Jh
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 1(6)
The 27-residue polypeptide omega-conotoxin GVIA (omega-CgTx), from the venom of the cone shell Conus geographus, blocks N-type neuronal calcium channels. It contains three disulphide bridges. We report here the synthesis and biological characterizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf755be4641ad4f5d4c8a4ea0817f37
https://pubmed.ncbi.nlm.nih.gov/9223017
https://pubmed.ncbi.nlm.nih.gov/9223017
Publikováno v:
Peptides 1994 ISBN: 9789072199218
Peptides 1994
Peptides 1994
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73873330ea9e6f534166874f11fc6e5a
https://doi.org/10.1007/978-94-011-1468-4_271
https://doi.org/10.1007/978-94-011-1468-4_271
Autor:
James P. Flinn, Michael J. Lew, James A. Angus, Paul K. Pallaghy, Roger Murphy, Raymond S. Norton
Publikováno v:
European Journal of Biochemistry. 264:268-268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8c7c6fba1f0e34470947830230ff2b5
https://doi.org/10.1046/j.1432-1327.1999.00744.x
https://doi.org/10.1046/j.1432-1327.1999.00744.x