Zobrazeno 1 - 10
of 10
pro vyhledávání: '"James P. Dobbs"'
Publikováno v:
Journal of Infectious Diseases. 118:114-124
The pathophysiological response following spore or toxin challenge was studied in rats. After challenge with anthrax toxin the electroencephalogram pattern showed cycles of depression in their normal activity, but just prior to death all electrical a
Publikováno v:
In Vitro. 9:108-113
The effect of changes in osmotic pressure and in the Na+/K+ ratio on the doubling time, maximum cell population, enzyme activity, and isoenzyme distribution pattern in suspension cultures of L cells was determined. The growth of viable cells is relat
Autor:
Kenneth J. Hendrix, Frederick Klein, David F. Fitzpatrick, William J. Jones, Jerry S. Walker, James P. Dobbs, Bill G. Mahlandt, Ralph E. Lincoln
Publikováno v:
Journal of Infectious Diseases. 116:123-138
The disease syndromes produced by both Bacillus anthracis organisms and by sterile in vitro toxins are orderly and predictable. Most of the signs and changes in the blood cellular, and gaseous elements occur late in the septicemic phase of disease, w
Autor:
William I. Jones, Frederick Klein, Bill G. Mahlandt, Jerry S. Walker, James P. Dobbs, Ralph E. Lincoln
Publikováno v:
Journal of Bacteriology. 94:600-608
Differences in in vivo growth rates of Bacillus anthracis in the bodies of infected rats and guinea pigs showed the effect of innate species resistance. The effect of two levels of immunity imposed on these hosts demonstrated that, as the degree of i
Autor:
Frederick Klein, Norman S. Remmele, Jerry S. Walker, Ralph E. Lincoln, James P. Dobbs, Bill G. Mahlandt
Publikováno v:
Journal of Infectious Diseases. 118:97-103
Anthrax toxin depressed the cerebral cortical electrical activity of both anesthetized and non anesthetized monkeys and anesthetized chimpanzees. Recordings on a physiograph recorder revealed changes in electrocardiogram and hypoxic hypertension that
Isoenzyme distribution patterns (zymograms) and enzymic-specific activities were determined for both suspension and monolayer cultures of the LM cell line, its clone (Cl l), and four sub-clones from this clone. Identical zymograms were obtained from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cc3621dda8c9a3f80fa47d5aa3691eb
https://doi.org/10.21236/ad0857265
https://doi.org/10.21236/ad0857265
Many of the biological and biophysical characteristics of the partially purified anthrax toxin components were measured. The components do not appear to be simple proteins. As the components are purified the pH range in which they are most stable nar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec7dc41b692bc788c8d5bbfb3c8f0799
https://doi.org/10.21236/ad0811816
https://doi.org/10.21236/ad0811816
Publikováno v:
Analytical biochemistry. 46(2)
The trimethylsilyl derivatives of 18 amino acids, 3 sugars and 2 vitamins present in a complex tissue culture medium have been prepared and separated by temperature-programmed gas-liquid chromatography. Identification is based upon retention time and
Publikováno v:
Journal of bacteriology. 95(3)
The three components of the toxin of Bacillus anthracis , edema factor (EF), protective antigen (PA), and lethal factor (LF), were purified 197-, 156-, and 1,025- fold, with 38, 78, and 11% recovery, respectively. Each purified component was serologi
Autor:
Donald C. Fish, James P. Dobbs
Publikováno v:
In vitro. 6(6)
The parent and two subclones of the L-M cell line were grown in shake, spinner, and monolayer culture in the presence or absence of 10% bovine serum and assayed to determine the effect of different cultural conditions upon enzyme activity. The assay