Zobrazeno 1 - 10
of 18
pro vyhledávání: '"James P. Chovan"'
Publikováno v:
Rapid Communications in Mass Spectrometry. 28:123-134
Rationale Recent publications have reported that imatinib forms cyanide and methoxylamine adducts in vitro but without detail structural identification. The current work reports the identification of seven cyanide adducts that elucidate the bioactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd88fb5662fc5ee1a4897d38a0807cb1
https://doi.org/10.1002/rcm.6758
https://doi.org/10.1002/rcm.6758
Publikováno v:
Chemical Research in Toxicology. 26:608-615
Medicinal chemists try to avoid certain organic functional groups, summarized in an ever-growing list, in order to avoid the potential bioactivation to reactive metabolites. To add to that alert list, we report herein that boronic acid-containing com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf2dbd55c242135d9eeb544334eb82f
https://doi.org/10.1021/tx400032n
https://doi.org/10.1021/tx400032n
Publikováno v:
Rapid Communications in Mass Spectrometry. 26:906-914
RATIONALE Drug metabolites that have imine or enamine partial structures cause extra mass-to-charge (m/z) increases in online hydrogen/deuterium exchange (HDX) in addition to hydroxyl or amine protons. Online HDX and exact mass measurement were used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af8152053188cfbc891a7ca6d49a77b3
https://doi.org/10.1002/rcm.6178
https://doi.org/10.1002/rcm.6178
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Bendamustine is a unique alkylating agent indicated for the treatment of chronic lymphocytic leukemia and rituximab-refractory, indolent B cell non-Hodgkin’s lymphoma. Despite the extensive experience with bendamustine, its pharmacokinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc39dccb7014e4da7ebad2adc89a5c84
https://pubmed.ncbi.nlm.nih.gov/25829094
https://pubmed.ncbi.nlm.nih.gov/25829094
Publikováno v:
Rapid communications in mass spectrometry : RCM. 28(1)
Recent publications have reported that imatinib forms cyanide and methoxylamine adducts in vitro but without detail structural identification. The current work reports the identification of seven cyanide adducts that elucidate the bioactivation pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7849e0cad7122f56c0b8ebd7735c688
https://pubmed.ncbi.nlm.nih.gov/24285397
https://pubmed.ncbi.nlm.nih.gov/24285397
Publikováno v:
Rapid communications in mass spectrometry : RCM. 26(8)
Drug metabolites that have imine or enamine partial structures cause extra mass-to-charge (m/z) increases in online hydrogen/deuterium exchange (HDX) in addition to hydroxyl or amine protons. Online HDX and exact mass measurement were used herein to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd371f6e4b930cdbc30fce71824defd6
https://pubmed.ncbi.nlm.nih.gov/22396026
https://pubmed.ncbi.nlm.nih.gov/22396026
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 578:77-83
CGS 21680 (2-[p-(2-carboxyethyl)phenylethylamino]-5'-N- ethylcarboxamidoadenosine, I) is a highly A2-selective (A2/A1 = 140), high-affinity adenosine agonist. A method has been devised to extract the compound from biological matrices with automated s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afaf86f742a85629ccbdaa8a4f416722
https://doi.org/10.1016/0378-4347(92)80227-h
https://doi.org/10.1016/0378-4347(92)80227-h
Publikováno v:
Cardiovascular Drug Reviews. 10:26-53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65a76708974a6b21060a688e46978c00
https://doi.org/10.1111/j.1527-3466.1992.tb00235.x
https://doi.org/10.1111/j.1527-3466.1992.tb00235.x
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 35(10)
Bendamustine, a bifunctional alkylating agent, is currently in clinical trials for the treatment of hematological and other malignancies. Although it has been used in the former East Germany for more than 30 years, very limited information is availab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0718fc641d93d775d6f5d7bed89e8256
https://pubmed.ncbi.nlm.nih.gov/17600082
https://pubmed.ncbi.nlm.nih.gov/17600082
Autor:
Mitchell B. Diccianni, Henry C. Nathan, James P. Chovan, Ilene H. Raisfeld-Danse, Cyrus J. Bacchi
Publikováno v:
Pharmacological Research Communications. 18:867-873
Although bleomycin is a known pulmonary toxin, results presented herein indicate its relative safety for treatment of trypanosomiasis. More than 4 times the curative dose in this acute model of infection does not induce significant alterations of lun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d432ffd109e6f6cc4f06a1e7d5e4fc
https://doi.org/10.1016/0031-6989(86)90136-0
https://doi.org/10.1016/0031-6989(86)90136-0