Zobrazeno 1 - 10
of 39
pro vyhledávání: '"James P. Carney"'
Publikováno v:
Drug Delivery, Vol 25, Iss 1, Pp 1234-1257 (2018)
Gene therapy has long held promise to correct a variety of human diseases and defects. Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the mechanism of the CRISPR-based prokaryotic adaptive immune system (CRISPR-a
Externí odkaz:
https://doaj.org/article/b314c626f737436fbb97e72220010ecc
Autor:
James P. Carney, Rachael Bernstein, Eric A. E. Garber, Jennifer L. Walker, Thomas W. O’Brien, Alena Calm, Jinny L. Liu, Ellen R. Goldman, Scott Walper, Dan Zabetakis, George P. Anderson
Publikováno v:
Toxins, Vol 3, Iss 11, Pp 1405-1419 (2011)
Llama derived single domain antibodies (sdAb), the recombinantly expressed variable heavy domains from the unique heavy-chain only antibodies of camelids, were isolated from a library derived from llamas immunized with a commercial abrin toxoid prepa
Externí odkaz:
https://doaj.org/article/c19eeac1a53e4b2ba31c8a97e669acff
Autor:
Adam Cook, Michael B. Sinclair, Jesse Cahill, Susan Esfahani, Andres Martinez-Sanchez, Patrick Sean Finnegan, Ryan P. Haggerty, David Ho, Andrew Glen, Jason Hinchcliffe, Jeffrey Lynch, Joseph S. Schoeniger, Nathan Fuller, Robert Guild Copeland, Marie Danielle Arrowsmith, William Reinholtz, Michael A. Gallegos, Jeffrey P. Koplow, Troy Reese, Derrick Higa, Steven Wood, James P. Carney
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::870112aaec9a804d1227e4a25672cae3
https://doi.org/10.2172/1668131
https://doi.org/10.2172/1668131
Autor:
Jerilyn A. Timlin, Matthew P. Hirakawa, Kimberly S. Butler, James P. Carney, Raga Krishnakumar
Publikováno v:
Bioscience Reports
Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly interspaced short palindromic repeat DNA sequences)/Cas9 are rapidly prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d74015071f96803afbc5b95c0d10a59
http://europepmc.org/articles/PMC7146048
http://europepmc.org/articles/PMC7146048
Publikováno v:
Drug Delivery
Drug Delivery, Vol 25, Iss 1, Pp 1234-1257 (2018)
Drug Delivery, Vol 25, Iss 1, Pp 1234-1257 (2018)
Gene therapy has long held promise to correct a variety of human diseases and defects. Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the mechanism of the CRISPR-based prokaryotic adaptive immune system (CRISPR-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c9b148ff7f14452f86e9fee6d7cd0b
https://doi.org/10.1080/10717544.2018.1474964
https://doi.org/10.1080/10717544.2018.1474964
Autor:
Tanya T. Paull, Julie Della-Maria, Miaw Sheue Tsai, Yi Zhou, James P. Carney, Jeff Kuhnlein, Alan E. Tomkinson
Publikováno v:
Journal of Biological Chemistry. 286:33845-33853
Recent studies have implicated a poorly defined alternative pathway of nonhomologous end joining (alt-NHEJ) in the generation of large deletions and chromosomal translocations that are frequently observed in cancer cells. Here, we describe an interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d89e128176e75c6e4bc25521e7e34d
https://doi.org/10.1074/jbc.m111.274159
https://doi.org/10.1074/jbc.m111.274159
Publikováno v:
Environmental and Molecular Mutagenesis. 49:388-398
The mismatch repair pathway is responsible for maintaining genomic stability by correcting base-base mismatches and insertion/deletion loops that arise mainly via replication errors. Additionally, the mismatch repair pathway performs a central role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049d1f4eeefef3f4ab6ea2d7432dd388
https://doi.org/10.1002/em.20398
https://doi.org/10.1002/em.20398
Autor:
James P. Carney, Dana Cahill
Publikováno v:
Mutagenesis. 22:269-274
The Mre11 complex (Mre11-Rad50-Nbs1) is involved in a diverse array of DNA metabolic processes including the response to DNA double-strand breaks (DSBs). The structure of Rad50 plays a key role in the DNA-binding and end-bridging activity of the comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d43969b56b38838f38653ca164ceda
https://doi.org/10.1093/mutage/gem011
https://doi.org/10.1093/mutage/gem011
Autor:
Daqing Li, Juong G. Rhee, Mohan Suntharalingam, Chuanfa Guo, James P. Carney, Bert W. O'Malley
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 67:273-278
Purpose: Local failure and toxicity to adjacent critical structures is a significant problem in radiation therapy of cancers of the head and neck. We are developing a gene therapy based method of sensitizing head/neck squamous cell carcinoma (HNSCC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e14a4e7e10da2fd686ad5c49339063
https://doi.org/10.1016/j.ijrobp.2006.09.019
https://doi.org/10.1016/j.ijrobp.2006.09.019
Autor:
Padraic Grattan-Smith, Philip E. Chen, Geoff W. Birrell, Martin F. Lavin, James P. Carney, Olivier J. Becherel, Giannino DelSal, Nuri Gueven
Publikováno v:
Cancer Research. 66:2907-2912
Ataxia-telangiectasia mutated (ATM), the protein defective in ataxia-telangiectasia, plays a central role in DNA damage response and signaling to cell cycle checkpoints. We describe here a cell line from a patient with an ataxia-telangiectasia–like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183dab2bebf7933f788436a60266be42
https://doi.org/10.1158/0008-5472.can-05-3428
https://doi.org/10.1158/0008-5472.can-05-3428