Zobrazeno 1 - 10
of 32
pro vyhledávání: '"James P. Jewell"'
Autor:
Christopher J. Dinsmore, Nancy E. Kohl, Qinwen Zeng, Alexander A. Szewczak, John F. Reilly, Xianlu Qu, Cloud P. Paweletz, Bart A. Lutterbach, Wei Lu, Kaiko Kunii, Jason D. Katz, Ilona Kariv, James P. Jewell, Harold Hatch, Gaozhen Hang, Susana Gil, Jackson B. Gibbs, Sujal V. Deshmukh, Lenora J. Davis, An Chi, Melissa Chenard, Grace K.Y. Chan, Bo-Sheng Pan
Supplementary Figure 3 from MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ead8a2c84ec1e9b5c7fd484d5aa73e
https://doi.org/10.1158/0008-5472.22383779
https://doi.org/10.1158/0008-5472.22383779
Autor:
Christopher J. Dinsmore, Nancy E. Kohl, Qinwen Zeng, Alexander A. Szewczak, John F. Reilly, Xianlu Qu, Cloud P. Paweletz, Bart A. Lutterbach, Wei Lu, Kaiko Kunii, Jason D. Katz, Ilona Kariv, James P. Jewell, Harold Hatch, Gaozhen Hang, Susana Gil, Jackson B. Gibbs, Sujal V. Deshmukh, Lenora J. Davis, An Chi, Melissa Chenard, Grace K.Y. Chan, Bo-Sheng Pan
Supplementary Figure 4 from MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054140e8884713105eec245eadc1cdda
https://doi.org/10.1158/0008-5472.22383776
https://doi.org/10.1158/0008-5472.22383776
Autor:
Christopher J. Dinsmore, Nancy E. Kohl, Qinwen Zeng, Alexander A. Szewczak, John F. Reilly, Xianlu Qu, Cloud P. Paweletz, Bart A. Lutterbach, Wei Lu, Kaiko Kunii, Jason D. Katz, Ilona Kariv, James P. Jewell, Harold Hatch, Gaozhen Hang, Susana Gil, Jackson B. Gibbs, Sujal V. Deshmukh, Lenora J. Davis, An Chi, Melissa Chenard, Grace K.Y. Chan, Bo-Sheng Pan
Supplementary Figure 2 from MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a65a09f92681267a6de3aaaa88df405
https://doi.org/10.1158/0008-5472.22383782
https://doi.org/10.1158/0008-5472.22383782
Autor:
Christopher J. Dinsmore, Nancy E. Kohl, Qinwen Zeng, Alexander A. Szewczak, John F. Reilly, Xianlu Qu, Cloud P. Paweletz, Bart A. Lutterbach, Wei Lu, Kaiko Kunii, Jason D. Katz, Ilona Kariv, James P. Jewell, Harold Hatch, Gaozhen Hang, Susana Gil, Jackson B. Gibbs, Sujal V. Deshmukh, Lenora J. Davis, An Chi, Melissa Chenard, Grace K.Y. Chan, Bo-Sheng Pan
Supplementary Figure 1 from MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d584751769fb485b613b5d4da0b8ad
https://doi.org/10.1158/0008-5472.22383785
https://doi.org/10.1158/0008-5472.22383785
Autor:
Christopher J. Dinsmore, Nancy E. Kohl, Qinwen Zeng, Alexander A. Szewczak, John F. Reilly, Xianlu Qu, Cloud P. Paweletz, Bart A. Lutterbach, Wei Lu, Kaiko Kunii, Jason D. Katz, Ilona Kariv, James P. Jewell, Harold Hatch, Gaozhen Hang, Susana Gil, Jackson B. Gibbs, Sujal V. Deshmukh, Lenora J. Davis, An Chi, Melissa Chenard, Grace K.Y. Chan, Bo-Sheng Pan
Supplementary Figure 5 from MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698732c4b28be2c0e774afa90e7f46c3
https://doi.org/10.1158/0008-5472.22383773.v1
https://doi.org/10.1158/0008-5472.22383773.v1
Autor:
Christopher J. Dinsmore, Nancy E. Kohl, Qinwen Zeng, Alexander A. Szewczak, John F. Reilly, Xianlu Qu, Cloud P. Paweletz, Bart A. Lutterbach, Wei Lu, Kaiko Kunii, Jason D. Katz, Ilona Kariv, James P. Jewell, Harold Hatch, Gaozhen Hang, Susana Gil, Jackson B. Gibbs, Sujal V. Deshmukh, Lenora J. Davis, An Chi, Melissa Chenard, Grace K.Y. Chan, Bo-Sheng Pan
Supplementary Methods, Table 1, Figure Legends 1-5 from MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4bf79ff1fd442ca0667d231c5117b6
https://doi.org/10.1158/0008-5472.22383770.v1
https://doi.org/10.1158/0008-5472.22383770.v1
Autor:
Laura Price, Samanthi A. Perera, Daniel F. Wyss, Johnny E. Kopinja, Saso Cemerski, Sharad K. Sharma, Timothy J. Henderson, Serena Xu, Andrew M. Haidle, Min Lu, George H. Addona, Greg O’Donnell, Berengere Sauvagnat, Gottfried K. Schroeder, Ilona Kariv, Larissa Rakhilina, Sriram Tyagarajan, Bo-Sheng Pan, Hyun Chong Woo, Brian Long, Jared N. Cumming, Brandon Cash, Yiping Chen, Ryan D. Otte, B. Wesley Trotter, Jeremy Presland, Jennifer Piesvaux, Brian M. Lacey, Rui Liang, Peter J. Dandliker, Ellen C. Minnihan, Charles A. Lesburg, Ian Knemeyer, Yanhong Ma, Guo Feng, David Jonathan Bennett, Michael D. Altman, Alexei V. Buevich, Jason Laskey, James P. Jewell, Wonsuk Chang
Publikováno v:
Signal Transduction and Targeted Therapy
Pharmacological activation of the STING (stimulator of interferon genes)-controlled innate immune pathway is a promising therapeutic strategy for cancer. Here we report the identification of MSA-2, an orally available non-nucleotide human STING agoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93434b3ed8c750bce8ca979d455db02c
https://doi.org/10.1126/science.aba6098
https://doi.org/10.1126/science.aba6098
Autor:
James Robbins Jewell
Publikováno v:
Scientia Militaria, Vol 31, Iss 1 (2012)
The Boer War, which is frequently referred to as Britain's Vietnam or Afghanistan, was marked by gross miscalculations on the part of both British military and political leaders. In their efforts to subdue the Boers, Britain used more troops, spent m
Externí odkaz:
https://doaj.org/article/4f085bee146b4399883d9a3786229be8
Autor:
Matthew G. Stanton, Sanjeev Munshi, Ian W. Davies, Kaleen Konrad Childers, Michael Hutton, Lee Warren, Mansuo Hayashi, Anna A. Zabierek, Alan B. Northrup, Alexander A. Szewczak, Hugh Nuthall, Andrew M. Haidle, Ben Munoz, Dapeng Chen, Hua-Poo Su, Yongquan Hou, Jason D. Katz, Andreas Harsch, Michael D. Altman, James P. Jewell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:114-120
The initial structure activity relationships around an isoindoline uHTS hit will be described. Information gleaned from ligand co-crystal structures allowed for rapid refinements in both MARK potency and kinase selectivity. These efforts allowed for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20493003f7f8446544809a814383d0f7
https://doi.org/10.1016/j.bmcl.2016.08.068
https://doi.org/10.1016/j.bmcl.2016.08.068
Autor:
Andrew M. Haidle, Alan B. Northrup, Alexander A. Szewczak, Lee Warren, Jason D. Katz, James P. Jewell, Mansuo Hayashi, Hugh Nuthall, Andreas Harsch, Michael D. Altman, Ian W. Davies, Dapeng Chen, Kaleen Konrad Childers, Michael Hutton, Anna A. Zabierek, Matthew G. Stanton, Yongquan Hou, Ben Munoz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:109-113
Attempts to optimize pharmacokinetic properties in a promising series of pyrrolopyrimidinone MARK inhibitors for the treatment of Alzheimer's disease are described. A focus on physical properties and ligand efficiency while prosecuting this series af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc8536570d3d5135b8796086271560b
https://doi.org/10.1016/j.bmcl.2016.08.066
https://doi.org/10.1016/j.bmcl.2016.08.066