Zobrazeno 1 - 10
of 26
pro vyhledávání: '"James P Strassner"'
Publikováno v:
The Journal of investigative dermatology. 142(12)
Vitiligo is an autoimmune skin disease caused by melanocyte-targeting autoreactive CD8+ T cells. Regulatory T cells (Tregs) have been implicated in restraining vitiligo severity in both mouse models and human patients; however, whether they must be p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b1d60bb92d6002170a8e5b38b56b3e
https://pubmed.ncbi.nlm.nih.gov/35777498
https://pubmed.ncbi.nlm.nih.gov/35777498
Autor:
Kyle J, Gellatly, James P, Strassner, Kingsley, Essien, Maggi Ahmed, Refat, Rachel L, Murphy, Anthony, Coffin-Schmitt, Amit G, Pandya, Andrea, Tovar-Garza, Michael L, Frisoli, Xueli, Fan, Xiaolan, Ding, Evangeline E, Kim, Zainab, Abbas, Patrick, McDonel, Manuel, Garber, John E, Harris
Publikováno v:
Sci Transl Med
Vitiligo is an autoimmune skin disease characterized by the targeted destruction of melanocytes by T cells. Cytokine signaling between keratinocytes and T cells results in CD8+ T cell infiltration of vitiligo lesions, but the full scope of signals re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::35696854ae7a1a54611a50533fe32e04
https://pubmed.ncbi.nlm.nih.gov/34516831
https://pubmed.ncbi.nlm.nih.gov/34516831
Autor:
Zainab Abbas, Michael L. Frisoli, Manuel Garber, Xueli Fan, Amit G. Pandya, James P. Strassner, Kingsley I. Essien, Evangeline E. Kim, Xiaolan Ding, Anthony Coffin-Schmitt, Maggi Ahmed Refat, Andrea Tovar-Garza, R. Murphy, Kyle Gellatly, John E. Harris, Patrick McDonel
Publikováno v:
Science Translational Medicine. 13
scRNA-seq of human vitiligo samples reveals complex autoimmune networks, including a role for CCR5 in T reg function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05198bef0ebdcf60ba64bbed231f6982
https://doi.org/10.1126/scitranslmed.abd8995
https://doi.org/10.1126/scitranslmed.abd8995
Autor:
John E. Harris, Madhuri Garg, Kingsley I. Essien, Priti Agarwal, L. Pell, Mehdi Rashighi, James P. Strassner, Jillian M. Richmond
Publikováno v:
Journal of Investigative Dermatology. 139:769-778
Tissue resident memory T cells (Trm) form in the skin in vitiligo and persist to maintain disease, as white spots often recur rapidly after discontinuing therapy. We and others have recently described melanocyte-specific autoreactive Trm in vitiligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bee47217b9f84b12397b719feec633
https://doi.org/10.1016/j.jid.2018.10.032
https://doi.org/10.1016/j.jid.2018.10.032
Autor:
John E. Harris, Rebecca L. Riding, James P. Strassner, Lucio Zapata, Jillian M. Richmond, Madhuri Garg, Melina Gjoni, Vincent Azzolino
Publikováno v:
J Invest Dermatol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1110101c7f2bb47fc6282640966401
https://europepmc.org/articles/PMC7686074/
https://europepmc.org/articles/PMC7686074/
Autor:
Xueli Fan, John E. Harris, Manuel Garber, Alan G. Derr, E. Kim, A. Coffin-Schmitt, Kyle Gellatly, X. Ding, Z. Abbas, R. Murphy, Patrick McDonel, Kingsley I. Essien, Michael L. Frisoli, M. Ahmed, James P. Strassner
Publikováno v:
Journal of Investigative Dermatology. 140:S19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3decdc2bbfa22e64c83e4ce6c2556094
https://doi.org/10.1016/j.jid.2020.03.167
https://doi.org/10.1016/j.jid.2020.03.167
Autor:
Kingsley I. Essien, Manuel Garber, E. Kim, James P. Strassner, Michael L. Frisoli, Z. Abbas, A. Coffin-Schmitt, X. Ding, Yetao Wang, John E. Harris, M. Ahmed, Patrick McDonel, Alan G. Derr, Xueli Fan, Mehdi Rashighi, Kyle Gellatly, R. Murphy
Publikováno v:
Journal of Investigative Dermatology. 140:S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25ecc16b02e050b13c002d46064fa4c1
https://doi.org/10.1016/j.jid.2020.03.095
https://doi.org/10.1016/j.jid.2020.03.095
Publikováno v:
Immunol Rev
Autoimmune skin diseases are complex processes in which autoreactive cells must navigate through the skin tissue to find their targets. Regulatory T cells in the skin help to mitigate autoimmune inflammation and may in fact be responsible for the pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcf5c7b37dad5270541b02675beed01
https://pubmed.ncbi.nlm.nih.gov/30977191
https://pubmed.ncbi.nlm.nih.gov/30977191
Autor:
John E. Harris, Lucio Zapata, Amit G. Pandya, Andrea Tovar-Garza, Vincent Azzolino, Xueli Fan, Maggi Ahmed Refat, Jillian M. Richmond, Rebecca L. Riding, J. Yun Tso, Madhuri Garg, Naoya Tsurushita, James P. Strassner
Publikováno v:
Science Translational Medicine. 10
Vitiligo is an autoimmune disease of the skin mediated by CD8(+) T cells that kill melanocytes and create white spots. Skin lesions in vitiligo frequently return after discontinuing conventional treatments, supporting the hypothesis that autoimmune m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb6ee21e38d46fd3f22f64e9a1cef58
https://doi.org/10.1126/scitranslmed.aam7710
https://doi.org/10.1126/scitranslmed.aam7710
Background Vitiligo is an autoimmune disease in which cutaneous depigmentation occurs. Existing therapies are often inadequate. Prior reports have shown benefit of the Janus kinase (JAK) inhibitors. Objective To evaluate the efficacy of the JAK 1/3 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cb72f636f896c718fa489086b9d086
https://europepmc.org/articles/PMC6233876/
https://europepmc.org/articles/PMC6233876/