Zobrazeno 1 - 10
of 39
pro vyhledávání: '"James P McGrath"'
Autor:
James B Reinecke, Sarah L DeVos, James P McGrath, Amanda M Shepard, Dustin K Goncharoff, Don N Tait, Samantha R Fleming, Michael P Vincent, Michelle L Steinhilb
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23865 (2011)
Alzheimer's disease and other related neurodegenerative disorders known as tauopathies are characterized by the accumulation of abnormally phosphorylated and aggregated forms of the microtubule-associated protein tau. Several laboratories have identi
Externí odkaz:
https://doaj.org/article/6b18e7488c294543af57f18c848bbca1
Autor:
Sasha Soldati, Alexander Bär, Mykhailo Vladymyrov, Dale Glavin, James L. McGrath, Fabien Gosselet, Hideaki Nishihara, Susan Goelz, Britta Engelhardt
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-22 (2023)
Abstract Introduction The humanized anti-α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis (RRMS) that is associated with the risk of progressive multifocal leukoencephalopathy (PM
Externí odkaz:
https://doaj.org/article/ac48d8c3d465490f8a3c4c2f105b86bd
Autor:
Divyanshu Sood, Ibrahim Alhindawi, Usman Ali, Donal Finn, James A. McGrath, Miriam A. Byrne, James O'Donnell
Publikováno v:
Data in Brief, Vol 49, Iss , Pp 109453- (2023)
The occupancy profile dataset presented in this study leverages publicly available UK Time Use Survey (TUS) 2014–15 data to evaluate the impact of occupancy on energy consumption at various spatial and temporal scales using multi-scale archetypes.
Externí odkaz:
https://doaj.org/article/a5877725113f4d14a3fe6aa3e0293069
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
High-content imaging techniques in conjunction with in vitro microphysiological systems (MPS) allow for novel explorations of physiological phenomena with a high degree of translational relevance due to the usage of human cell lines. MPS featuring ul
Externí odkaz:
https://doaj.org/article/ff52bb8e27944a98af95d50bfccb70f8
Autor:
James A. McGrath, Andrew O’Sullivan, Mary Joyce, Miriam A. Byrne, Jie Li, James B. Fink, Ronan MacLoughlin
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
The use of high-flow nasal cannula in the treatment of COVID-19 infected patients has proven to be a valuable treatment option to improve oxygenation. Early in the pandemic, there were concerns for the degree of risk of disease transmission to health
Externí odkaz:
https://doaj.org/article/5f76b4f63bd6417dbec973dc8d390d9d
Autor:
Molly C. McCloskey, Victor Z. Zhang, S. Danial Ahmad, Samuel Walker, Samantha S. Romanick, Hani A. Awad, James L. McGrath
Publikováno v:
Frontiers in Medical Technology, Vol 4 (2022)
The vascular system plays a critical role in the progression and resolution of inflammation. The contributions of the vascular endothelium to these processes, however, vary with tissue and disease state. Recently, tissue chip models have emerged as p
Externí odkaz:
https://doaj.org/article/1d80af8fb7f54b139a781ccb8eb257fa
Autor:
Alec T. Salminen, Molly C. McCloskey, S. Danial Ahmad, Samantha S. Romanick, Kaihua Chen, William Houlihan, Michael E. Klaczko, Jonathan Flax, Richard E. Waugh, James L. McGrath
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 3, Pp 151233- (2022)
Sphingosine-1-phosphate (S1P) signals to enhance or destabilize the vascular endothelial barrier depending on the receptor engaged. Here, we investigated the differential barrier effects of S1P on two influential primary endothelial cell (EC) types,
Externí odkaz:
https://doaj.org/article/2cfd6aa215d54b85b8950a145f7bc5dd
Autor:
Diana Hudecz, Molly C. McCloskey, Sandra Vergo, Søren Christensen, James L. McGrath, Morten S. Nielsen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5624 (2023)
Understanding the vesicular trafficking of receptors and receptor ligands in the brain capillary endothelium is essential for the development of the next generations of biologics targeting neurodegenerative diseases. Such complex biological questions
Externí odkaz:
https://doaj.org/article/2044823f3846458f8ae626d2e4b292d5
Autor:
Alison Connolly, Holger M. Koch, Daniel Bury, Stephan Koslitz, Marike Kolossa-Gehring, André Conrad, Aline Murawski, James A. McGrath, Michelle Leahy, Thomas Brüning, Marie A. Coggins
Publikováno v:
Toxics, Vol 10, Iss 11, p 690 (2022)
Glyphosate-based pesticides are the highest-volume used herbicides worldwide. International concerns regarding the potential human adverse effects of glyphosate exposures have heightened since IARC classified glyphosate as probably carcinogenic to hu
Externí odkaz:
https://doaj.org/article/6067195c34ae46b3a16b6328979f59e1
Autor:
Elysia A. Masters, Gowrishankar Muthukrishnan, Lananh Ho, Ann Lindley Gill, Karen L. de Mesy Bentley, Chad A. Galloway, James L. McGrath, Hani A. Awad, Steven R. Gill, Edward M. Schwarz
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Staphylococcus aureus invasion of the osteocyte lacuno-canalicular network (OLCN) is a novel mechanism of bacterial persistence and immune evasion in chronic osteomyelitis. Previous work highlighted S. aureus cell wall transpeptidase, penicillin bind
Externí odkaz:
https://doaj.org/article/9f13972546dd407aa4bcffa9929fcc8f