Zobrazeno 1 - 10
of 30
pro vyhledávání: '"James P Held"'
Autor:
James P Held, Gaomin Feng, Benjamin R Saunders, Claudia V Pereira, Kristopher Burkewitz, Maulik R Patel
Publikováno v:
eLife, Vol 11 (2022)
The mitochondrial unfolded protein response (UPRmt) has emerged as a predominant mechanism that preserves mitochondrial function. Consequently, multiple pathways likely exist to modulate UPRmt. We discovered that the tRNA processing enzyme, homolog o
Externí odkaz:
https://doaj.org/article/c81b9865a2cf48a6b5e913ca67b984b5
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Cells possess multiple mitochondrial DNA (mtDNA) copies, which undergo semi-autonomous replication and stochastic inheritance. This enables mutant mtDNA variants to arise and selfishly compete with cooperative (wildtype) mtDNA. Selfish mitoc
Externí odkaz:
https://doaj.org/article/fa80ab2a5a5d4fbd893919cdafd231ec
Autor:
Nikita Tsyba, Gaomin Feng, Lantana K. Grub, James P. Held, Adrianna M. Strozak, Kristopher Burkewitz, Maulik R. Patel
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106349- (2023)
Summary: Mutations in the mitochondrial genome (mtDNA) can be pathogenic. Owing to the multi-copy nature of mtDNA, wild-type copies can compensate for the effects of mutant mtDNA. Wild-type copies available for compensation vary depending on the muta
Externí odkaz:
https://doaj.org/article/eb30915a8efc4f3b8dbbe9a36ff2fad2
Autor:
James P. Held, Maulik R. Patel
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-4 (2020)
Abstract Objective Mitochondria-encoded ribosomal RNA (rRNA) genes in humans are expressed at a higher rate than protein coding genes of the mitochondria. The organization of the human mitochondrial genome (mtDNA) is amenable to differential expressi
Externí odkaz:
https://doaj.org/article/38ad86d19f6c49439f37fa358bc6380b
Publikováno v:
Agrosystems, Geosciences & Environment, Vol 2, Iss 1, Pp 1-4 (2019)
Core Ideas New low linolenic soybean with novel alleles of FAD3A and FAD3C. Mutation in GmFAD3C reduces linolenic acid levels. Soybean FAD3C controls linolenic acid levels. Conventional commodity soybean oil can typically have levels of linolenic aci
Externí odkaz:
https://doaj.org/article/39a994c0432749c5b13d6528b984d819
Autor:
Lantana K. Grub, James P. Held, Tyler J. Hansen, Samantha H. Schaffner, Marleigh R. Canter, Evi M. Malagise, Maulik R. Patel
Publikováno v:
bioRxiv
Epigenetic modifications provide powerful means for transmitting information from parent to progeny. As a maternally inherited genome that encodes essential components of the electron transport chain, the mitochondrial genome (mtDNA) is ideally posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98cf477e25c1ae9b70e811517a27c1ba
https://doi.org/10.1101/2023.03.27.534452
https://doi.org/10.1101/2023.03.27.534452
Mutant copies of mitochondrial DNA (mtDNA) can behave as selfish entities, propagating within organisms at the expense of host fitness. We previously developed experiments to separately measure the within-host proliferation, and host fitness cost, of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b5d16ba3ab3edb578eb5fcef1f42808
https://doi.org/10.1101/2022.04.08.487647
https://doi.org/10.1101/2022.04.08.487647
Autor:
James P Held, Gaomin Feng, Benjamin R Saunders, Claudia V Pereira, Kristopher Burkewitz, Maulik R Patel
Publikováno v:
eLife. 11
The mitochondrial unfolded protein response (UPRmt) has emerged as a predominant mechanism that preserves mitochondrial function. Consequently, multiple pathways likely exist to modulate UPRmt. We discovered that the tRNA processing enzyme, homolog o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8871ff7377935ac8fe35b0ec67db2211
https://pubmed.ncbi.nlm.nih.gov/35451962
https://pubmed.ncbi.nlm.nih.gov/35451962
The mitochondrial unfolded protein response (UPRmt) has emerged as a predominant mechanism that preserves mitochondrial function. Consequently, multiple pathways likely exist to modulate UPRmt. We unexpectedly discovered that the tRNA processing enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76ac48a23da96bb870a085ca7dd1069e
https://doi.org/10.1101/2021.06.22.449331
https://doi.org/10.1101/2021.06.22.449331