Zobrazeno 1 - 10
of 39
pro vyhledávání: '"James P Cooney"'
Autor:
Julio Carrera Montoya, Simon Collett, Daniel Fernandez Ruiz, Linda Earnest, Melissa A. Edeling, Ashley Huey Yiing Yap, Chinn Yi Wong, James P. Cooney, Kathryn C. Davidson, Jason Roberts, Steven Rockman, Bang M. Tran, Julie L. McAuley, Georgia Deliyannis, Samantha L. Grimley, Damian F. J. Purcell, Shafagh A. Waters, Dale I. Godfrey, Dhiraj Hans, Marc Pellegrini, Jason M. Mackenzie, Elizabeth Vincan, William R. Heath, Joseph Torresi
Publikováno v:
Organoids, Vol 3, Iss 1, Pp 18-31 (2024)
Existing mRNA COVID-19 vaccines have shown efficacy in reducing severe cases and fatalities. However, their effectiveness against infection caused by emerging SARS-CoV-2 variants has waned considerably, necessitating the development of variant vaccin
Externí odkaz:
https://doaj.org/article/cf1701857c3e4eef8731f1d72ff37ded
Autor:
Stefanie M. Bader, James P. Cooney, Reet Bhandari, Liana Mackiewicz, Merle Dayton, Dylan Sheerin, Smitha Rose Georgy, James M. Murphy, Kathryn C. Davidson, Cody C. Allison, Marc Pellegrini, Marcel Doerflinger
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Necroptosis, a type of lytic cell death executed by the pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) has been implicated in the detrimental inflammation caused by SARS-CoV-2 infection. We minimally and extensively passaged a single c
Externí odkaz:
https://doaj.org/article/d0d84b67dcff4c1baeac91fcb9c53843
Autor:
Georgia Deliyannis, Nicholas A. Gherardin, Chinn Yi Wong, Samantha L. Grimley, James P. Cooney, Samuel J. Redmond, Paula Ellenberg, Kathryn C. Davidson, Francesca L. Mordant, Tim Smith, Marianne Gillard, Ester Lopez, Julie McAuley, Chee Wah Tan, Jing J. Wang, Weiguang Zeng, Mason Littlejohn, Runhong Zhou, Jasper Fuk-Woo Chan, Zhi-wei Chen, Airn E. Hartwig, Richard Bowen, Jason M. Mackenzie, Elizabeth Vincan, Joseph Torresi, Katherine Kedzierska, Colin W. Pouton, Tom P. Gordon, Lin-fa Wang, Stephen J. Kent, Adam K. Wheatley, Sharon R. Lewin, Kanta Subbarao, Amy W. Chung, Marc Pellegrini, Trent Munro, Terry Nolan, Steven Rockman, David C. Jackson, Damian F.J. Purcell, Dale I. Godfrey
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104574- (2023)
Summary: Background: The SARS-CoV-2 global pandemic has fuelled the generation of vaccines at an unprecedented pace and scale. However, many challenges remain, including: the emergence of vaccine-resistant mutant viruses, vaccine stability during sto
Externí odkaz:
https://doaj.org/article/3f8a77f37e1f498db21c0e05005ef2d3
Autor:
Bruce D. Wines, Liriye Kurtovic, Halina M. Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L. Mordant, Wen Shi Lee, Nicholas A. Gherardin, Sheila K. Patel, Gemma E. Hartley, Phillip Pymm, James P. Cooney, James G. Beeson, Dale I. Godfrey, Louise M. Burrell, Menno C. van Zelm, Adam K. Wheatley, Amy W. Chung, Wai-Hong Tham, Kanta Subbarao, Stephen J. Kent, P. Mark Hogarth
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/140fea88883d408989768880a06ffb83
Autor:
Phillip Pymm, Samuel J. Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P. Cooney, Kathryn C. Davidson, Ebene R. Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L. Grimley, Damian F.J. Purcell, Stephen J. Kent, Adam K. Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W. Chung, Kanta Subbarao, Adam P. Uldrich, Wai-Hong Tham, Dale I. Godfrey, Nicholas A. Gherardin
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105259- (2022)
Summary: The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monoclonal antibodies and nanobodies that neutralize virus, have potential for the treatment of active disease. Here,
Externí odkaz:
https://doaj.org/article/8d6f566f8f3c4f6d9a283613b3b50fb7
Autor:
Bruce D. Wines, Liriye Kurtovic, Halina M. Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L. Mordant, Wen Shi Lee, Nicholas A. Gherardin, Sheila K. Patel, Gemma E. Hartley, Phillip Pymm, James P. Cooney, James G. Beeson, Dale I. Godfrey, Louise M. Burrell, Menno C. van Zelm, Adam K. Wheatley, Amy W. Chung, Wai-Hong Tham, Kanta Subbarao, Stephen J. Kent, P. Mark Hogarth
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain transcending virus neutralizing activity. SARS-CoV-2 neutralization and Fc-effector functions of ACE2-Fc decoy proteins,
Externí odkaz:
https://doaj.org/article/3a2991630f9b42fdb65b29d07a0e335f
Autor:
Dale J. Calleja, Nathan Kuchel, Bernadine G. C. Lu, Richard W. Birkinshaw, Theresa Klemm, Marcel Doerflinger, James P. Cooney, Liana Mackiewicz, Amanda E. Au, Yu Q. Yap, Timothy R Blackmore, Kasiram Katneni, Elly Crighton, Janet Newman, Kate E. Jarman, Melissa J. Call, Bernhard C. Lechtenberg, Peter E. Czabotar, Marc Pellegrini, Susan A. Charman, Kym N. Lowes, Jeffrey P. Mitchell, Ueli Nachbur, Guillaume Lessene, David Komander
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral treatment options to prevent hospitalization and death of patients infected with SARS-CoV-2. The papain-like protease (PLpro) domain is part of the SARS-CoV-2 non
Externí odkaz:
https://doaj.org/article/78066ca793204c13adcbf61221072dfc
Publikováno v:
Biochemical Journal. 479:609-628
Two years after the emergence of SARS-CoV-2, our understanding of COVID-19 disease pathogenesis is still incomplete. Despite unprecedented global collaborative scientific efforts and rapid vaccine development, an uneven vaccine roll-out and the emerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782952c1ae0a7d6ea0b501a7e096edcb
https://doi.org/10.1042/bcj20210602
https://doi.org/10.1042/bcj20210602
Autor:
Cody C. Allison, Marc Pellegrini, Miles B Horton, Simon Preston, Marcel Doerflinger, James P Cooney, Hamish W Scott
Publikováno v:
Immunology and Cell Biology
The stress‐activated protein kinases (SAPKs)/c‐Jun‐N‐terminal‐kinases (JNK) are members of the mitogen‐activated protein kinase family. These kinases are responsible for transducing cellular signals through a phosphorylation‐dependent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8c7b1174551b03b2b0416902fa84b1
http://europepmc.org/articles/PMC8247422
http://europepmc.org/articles/PMC8247422
Autor:
Simon P. Preston, Michael D. Stutz, Cody C. Allison, Ueli Nachbur, Quentin Gouil, Bang Manh Tran, Valerie Duvivier, Philip Arandjelovic, James P. Cooney, Liana Mackiewicz, Yanxiang Meng, Jan Schaefer, Stefanie M. Bader, Hongke Peng, Zina Valaydon, Pravin Rajasekaran, Charlie Jennison, Sash Lopaticki, Ann Farrell, Marno Ryan, Jess Howell, Catherine Croagh, Denuja Karunakaran, Carole Schuster-Klein, James M. Murphy, Theodora Fifis, Christopher Christophi, Elizabeth Vincan, Marnie E. Blewitt, Alexander Thompson, Justin A. Boddey, Marcel Doerflinger, Marc Pellegrini
Publikováno v:
Gastroenterology. 163(6)
Necroptosis is a highly inflammatory mode of cell death that has been implicated in causing hepatic injury including steatohepatitis/ nonalcoholic steatohepatitis (NASH); however, the evidence supporting these claims has been controversial. A compreh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a48aac57c10be5bd2a7390df7ce977
https://pubmed.ncbi.nlm.nih.gov/36155192
https://pubmed.ncbi.nlm.nih.gov/36155192