Zobrazeno 1 - 10
of 281
pro vyhledávání: '"James P, Simmer"'
Autor:
Shih-Kai Wang, Hong Zhang, Hua-Chieh Lin, Yin-Lin Wang, Shu-Chun Lin, Figen Seymen, Mine Koruyucu, James P. Simmer, Jan C.-C. Hu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6132 (2024)
AMELX mutations cause X-linked amelogenesis imperfecta (AI), known as AI types IE, IIB, and IIC in Witkop’s classification, characterized by hypoplastic (reduced thickness) and/or hypomaturation (reduced hardness) enamel defects. In this study, we
Externí odkaz:
https://doaj.org/article/eda180a328994f63a11ce2a415b4b175
Autor:
Tian Liang, Charles E. Smith, Yuanyuan Hu, Hong Zhang, Chuhua Zhang, Qian Xu, Yongbo Lu, Ling Qi, Jan C.-C. Hu, James P. Simmer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Dentin sialophosphoprotein (DSPP) is primarily expressed by differentiated odontoblasts (dentin-forming cells), and transiently expressed by presecretory ameloblasts (enamel-forming cells). Disease-causing DSPP mutations predominantly fall i
Externí odkaz:
https://doaj.org/article/55ab9e745bdb4551b1c1f56ebfdaf75c
Autor:
Tian Liang, Shih-Kai Wang, Charles Smith, Hong Zhang, Yuanyuan Hu, Figen Seymen, Mine Koruyucu, Yelda Kasimoglu, Jung-Wook Kim, Chuhua Zhang, Thomas L. Saunders, James P. Simmer, Jan C.-C. Hu
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-20 (2022)
Abstract Human ACP4 (OMIM*606362) encodes a transmembrane protein that belongs to histidine acid phosphatase (ACP) family. Recessive mutations in ACP4 cause non-syndromic hypoplastic amelogenesis imperfecta (AI1J, OMIM#617297). While ACP activity has
Externí odkaz:
https://doaj.org/article/b1ed9c32d099421cbc3e834f910de5b2
Autor:
Tian Liang, Yuanyuan Hu, Hong Zhang, Qian Xu, Charles E. Smith, Chuhua Zhang, Jung-Wook Kim, Shih-Kai Wang, Thomas L. Saunders, Yongbo Lu, Jan C.-C. Hu, James P. Simmer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Non-syndromic inherited defects of tooth dentin are caused by two classes of dominant negative/gain-of-function mutations in dentin sialophosphoprotein (DSPP): 5′ mutations affecting an N-terminal targeting sequence and 3′ mutations that
Externí odkaz:
https://doaj.org/article/8cc6c2e7bcd84aac8371c3b57be3059c
Autor:
Mengqi Zhou, Hong Zhang, Heather Camhi, Figen Seymen, Mine Koruyucu, Yelda Kasimoglu, Jung-Wook Kim, Hera Kim-Berman, Ninna M. R. Yuson, Paul J. Benke, Yiqun Wu, Feng Wang, Yaqin Zhu, James P. Simmer, Jan C-C. Hu
Publikováno v:
International Journal of Oral Science, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract Oligodontia is the congenital absence of six or more teeth and comprises the more severe forms of tooth agenesis. Many genes have been implicated in the etiology of tooth agenesis, which is highly variable in its clinical presentation. The p
Externí odkaz:
https://doaj.org/article/b4fae4e706cc42399f6b5e82f45aca92
Autor:
John D. Bartlett, Charles E. Smith, Yuanyuan Hu, Atsushi Ikeda, Mike Strauss, Tian Liang, Ya-Hsiang Hsu, Amanda H. Trout, David W. McComb, Rebecca C. Freeman, James P. Simmer, Jan C.-C. Hu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Dental enamel forms extracellularly as thin ribbons of amorphous calcium phosphate (ACP) that initiate on dentin mineral in close proximity to the ameloblast distal membrane. Secreted proteins are critical for this process. Enam −/− and
Externí odkaz:
https://doaj.org/article/373d5cee0dcd4f0582e0f4f3a8212285
Autor:
Tian Liang, Yuanyuan Hu, Kazuhiko Kawasaki, Hong Zhang, Chuhua Zhang, Thomas L. Saunders, James P. Simmer, Jan C.-C. Hu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Mutations of Odontogenesis-Associated Phosphoprotein (ODAPH, OMIM *614829) cause autosomal recessive amelogenesis imperfecta, however, the function of ODAPH during amelogenesis is unknown. Here we characterized normal Odaph expression by in
Externí odkaz:
https://doaj.org/article/f825654de1574935abc8ae63c714cbe8
Autor:
Shih‐Kai Wang, Hong Zhang, Michael B. Chavez, Yuanyuan Hu, Figen Seymen, Mine Koruyucu, Yelda Kasimoglu, Connor D. Colvin, Tamara N. Kolli, Michelle H. Tan, Yin‐Lin Wang, Pei‐Ying Lu, Jung‐Wook Kim, Brian L. Foster, John D. Bartlett, James P. Simmer, Jan C.‐C. Hu
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 8, Pp n/a-n/a (2020)
Abstract Background Matrix metallopeptidase 20 (MMP20) is an evolutionarily conserved protease that is essential for processing enamel matrix proteins during dental enamel formation. MMP20 mutations cause human autosomal recessive pigmented hypomatur
Externí odkaz:
https://doaj.org/article/89d3f87d0001415bb348c887bd7e7fc1
Autor:
Yasuo Yamakoshi, James P. Simmer
Publikováno v:
Japanese Dental Science Review, Vol 54, Iss 4, Pp 183-196 (2018)
Summary: Dentin sialophosphoprotein (DSPP) plays an important role in the formation of dentin. Understanding its structure and function would provide important insights into the regulation of dentin mineralization. For the past 15 years, we have been
Externí odkaz:
https://doaj.org/article/39c79822e68d48928fb86215ea49a659
Autor:
Mengqi Zhou, Hong Zhang, Heather Camhi, Figen Seymen, Mine Koruyucu, Yelda Kasimoglu, Jung-Wook Kim, Hera Kim-Berman, Ninna M. R. Yuson, Paul J. Benke, Yiqun Wu, Feng Wang, Yaqin Zhu, James P. Simmer, Jan C-C. Hu
Publikováno v:
International Journal of Oral Science, Vol 13, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/69aca93b9fdf4733af20c92ca8e7c19f