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Akademický článek

Analysis of apoB Concentrations Across Early Adulthood and Predictors for Rates of Change Using CARDIA Study Data

Autor: John T. Wilkins, Hongyan Ning, Allan Sniderman, Neil Stone, James Otvos, David R. Jacobs, Jr., Ravi Shah, Venkatesh L. Murthy, Jamal Rana, Norrina Allen, Donald M. Lloyd-Jones

Publikováno v: Journal of Lipid Research, Vol 63, Iss 12, Pp 100299- (2022)

The cumulative exposure to apolipoprotein B (apoB)-containing lipoproteins in the blood during early adult life is a central determinant of atherosclerotic cardiovascular disease risk. To date, the patterns and rates of change in apoB through early a

Externí odkaz: https://doaj.org/article/8c10e7e1cae447dda2a3d11d5afcdecb

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Akademický článek

Association of N-Linked Glycoprotein Acetyls and Colorectal Cancer Incidence and Mortality.

Autor: Paulette D Chandler, Akintunde O Akinkuolie, Deirdre K Tobias, Patrick R Lawler, Chungying Li, M Vinayaga Moorthy, Lu Wang, Daniel A Duprez, David R Jacobs, Robert J Glynn, James Otvos, Margery A Connelly, Wendy S Post, Paul M Ridker, JoAnn E Manson, Julie E Buring, I-Min Lee, Samia Mora

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0165615 (2016)

Acute phase proteins highlight the dynamic interaction between inflammation and oncogenesis. GlycA, a novel nuclear magnetic resonance (NMR) inflammatory marker that identifies primarily circulating N-acetyl glycan groups attached to acute phase prot

Externí odkaz: https://doaj.org/article/1c9f2f58a9a34094ac24619ce622599d

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Akademický článek

Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size

Autor: Herman J. Kempen, Dorota B. Schranz, Bela F. Asztalos, James Otvos, Elias Jeyarajah, Denise Drazul-Schrader, Heidi L. Collins, Steven J. Adelman, Peter L. J. Wijngaard

Publikováno v: Journal of Lipids, Vol 2014 (2014)

MDCO-216 is a complex of dimeric ApoA-IMilano and palmitoyl oleoyl phosphatidylcholine (POPC), previously shown to reduce atherosclerotic plaque burden. Here we studied the effect of incubation of human plasma or serum with MDCO-216 on cholesterol ef

Externí odkaz: https://doaj.org/article/afeacca9b1f14e15b754edbc42c22a3e

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Circulating ketone bodies and cardiovascular outcomes: the MESA study

Autor: Elad Shemesh, Parag Anilkumar Chevli, Tareq Islam, Charles A German, James Otvos, Joseph Yeboah, Fatima Rodriguez, Christopher deFilippi, Joao A C Lima, Michael Blaha, Ambarish Pandey, Muthiah Vaduganathan, Michael D Shapiro

Publikováno v: European Heart Journal. 44:1636-1646

Aims Ketone bodies (KB) are an important alternative metabolic fuel source for the myocardium. Experimental and human investigations suggest that KB may have protective effects in patients with heart failure. This study aimed to examine the associati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d99dc3b599511e2f78322277d3fa4fa
https://doi.org/10.1093/eurheartj/ehad087

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Abstract 10909: LDL and HDL Particle vs. Cholesterol Concentration in Metabolic Syndrome and Diabetes for the Prediction of Coronary Heart Disease: The Multiethnic Study of Atherosclerosis

Autor: David M Tehrani, Yanglu Zhao, Michael Blaha, Samia Mora, Rachel Mackey, Erin Michos, Matthew Budoff, William Cromwell, James Otvos, Paul Rosenblit, Nathan Wong

Publikováno v: Circulation. 132

Background: A more important role of both low and density lipoprotein (LDL-P and HDL-P) than cholesterol (LDL-C and HDL-C) concentration in predicting coronary heart disease (CHD) has been noted. However, the role of these factors and extent of parti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a57e1101d9a72ede2484a1d01e975648
https://doi.org/10.1161/circ.132.suppl_3.10909

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BOTH THE NOVEL NMR BIOMARKER OF INFLAMMATION, GLYCA, AND HS-CRP ARE INDEPENDENT AND ADDITIVE PREDICTORS OF FUTURE CARDIOVASCULAR EVENTS AMONG PATIENTS UNDERGOING CORONARY ANGIOGRAPHY: RESULTS FROM THE INTERMOUNTAIN HEART COLLABORATIVE STUDY

Autor: Kirk U. Knowlton, J. Brent Muhlestein, Oxana Galenko, Margery Connelly, Donald L. Lappé, Jeffrey L. Anderson, Heidi May, James Otvos

Publikováno v: Journal of the American College of Cardiology. 69:1069

Background: GlycA, a novel marker of inflammation, has been associated with future CV risk among patients with or without pre-existing coronary artery disease (CAD). Whether GlycA is an independent and additive predictor of high sensitivity C-reactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72ffdfed4ab6061af7b9b8674b74cf8d
https://doi.org/10.1016/s0735-1097(17)34458-3

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Abstract 238: Incubation of MDCO216 With Human Serum or Plasma Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Increases Prebeta-1 HDL and Causes a Shift From Small to Large Alpha HDL Particles

Autor: Herman J Kempen, Dorota B Schranz, Bela Asztalos, Elias Jeyarajah, James Otvos, Denise Drazul-Schrader, Heidi L Collins, Steven J Adelman

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 34

MDCO216 is a complex of dimeric apoA-IMilano and POPC, shown to reduce atherosclerotic plaque burden. Here we studied the effect of incubation of human plasma or serum with MDCO216 on cholesterol efflux capacity from J774 cells, on prebeta-1 HDL and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a61908c84b56fc0befdcb51352b2a58b
https://doi.org/10.1161/atvb.34.suppl_1.238

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