Zobrazeno 1 - 10
of 46
pro vyhledávání: '"James O. Wrabl"'
Autor:
Jing Li, Jordan T White, Harry Saavedra, James O Wrabl, Hesam N Motlagh, Kaixian Liu, James Sowers, Trina A Schroer, E Brad Thompson, Vincent J Hilser
Publikováno v:
eLife, Vol 7 (2018)
Externí odkaz:
https://doaj.org/article/c0004bf7a3a046f2a14e1fb94a4b0b58
Autor:
Jing Li, Jordan T White, Harry Saavedra, James O Wrabl, Hesam N Motlagh, Kaixian Liu, James Sowers, Trina A Schroer, E Brad Thompson, Vincent J Hilser
Publikováno v:
eLife, Vol 6 (2017)
Intrinsically disordered proteins (IDPs) present a functional paradox because they lack stable tertiary structure, but nonetheless play a central role in signaling, utilizing a process known as allostery. Historically, allostery in structured protein
Externí odkaz:
https://doaj.org/article/81a4ece1461a4f0e95dcde41379da803
Publikováno v:
Molecular biology and evolution. 39(3)
Protein stability is a fundamental molecular property enabling organisms to adapt to their biological niches. How this is facilitated and whether there are kingdom specific or more general universal strategies are unknown. A principal obstacle to add
“Metamorphic” proteins challenge state-of-the-art structure prediction methods reliant on amino acid similarity. Unfortunately, this obviates a more effective thermodynamic approach necessary to properly evaluate the impact of amino acid changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21d6158ae716b96e9ffb64f5d758a20a
https://doi.org/10.1101/2021.11.16.468851
https://doi.org/10.1101/2021.11.16.468851
Autor:
James Rives, E. Brad Thompson, Jordan T. White, James O. Wrabl, Vincent J. Hilser, Marla E. Tharp
Publikováno v:
Biochemistry. 60(21)
Tumor susceptibility gene 101 (TSG101) is involved in endosomal maturation and has been implicated in the transcriptional regulation of several steroid hormone receptors, although a detailed characterization of such regulation has yet to be conducted
Publikováno v:
Biophys J
Defining the role of intrinsic disorder in proteins in the myriad of biological processes with which it is involved represents a significant goal in modern biophysics. Toward this end, NMR is uniquely suited for molecular studies of dynamic and disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5945ee7e34f23b37e948e05950418e
https://europepmc.org/articles/PMC8390865/
https://europepmc.org/articles/PMC8390865/
Publikováno v:
Journal of the American Chemical Society. 141:10821-10829
High fidelity human mitochondrial DNA polymerase (Pol γ) contains two active sites, a DNA polymerization site (pol) and a 3′−5′ exonuclease site (exo) for proofreading. Although separated by 35 Å, coordination between the pol and exo sites is
Autor:
Srona Sengupta, Robert F. Siliciano, Janet D. Siliciano, Steven G. Deeks, Andrew E. Timmons, Josephine Zhang, Scheherazade Sadegh-Nasseri, Weiming Yang, Tatiana Boronina, Rebecca Hoh, Jeanna Yu, James O. Wrabl, Aeryon Kim, Robert N. Cole, Madison C. Reed, Robin A. Welsh
Publikováno v:
SSRN Electronic Journal.
Distinct CD4+T cell epitopes have been associated with spontaneous control of HIV-1 replication, but analysis of antigen-dependent factors that influence epitope selection is lacking. To examine these factors, we used a cell-free antigen processing s
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 10, p e1003247 (2013)
An algorithm is presented that returns the optimal pairwise gapped alignment of two sets of signed numerical sequence values. One distinguishing feature of this algorithm is a flexible comparison engine (based on both relative shape and absolute simi
Externí odkaz:
https://doaj.org/article/42a7d30547e84d79aa5f7cf279270c4d
Autor:
Jordan T. White, James Rives, Marla E. Tharp, E. Brad Thompson, Vincent J. Hilser, James O. Wrabl
Tumor Susceptibility Gene-101 (TSG101) is involved in endosomal maturation and has been implicated in the transcriptional regulation of several steroid hormone receptors (SHRs), although a detailed characterization of such regulation has yet to be co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd895cdfa421e027fe368b88e9feb813