Zobrazeno 1 - 10
of 45
pro vyhledávání: '"James O Wrabl"'
Autor:
Jing Li, Jordan T White, Harry Saavedra, James O Wrabl, Hesam N Motlagh, Kaixian Liu, James Sowers, Trina A Schroer, E Brad Thompson, Vincent J Hilser
Publikováno v:
eLife, Vol 7 (2018)
Externí odkaz:
https://doaj.org/article/c0004bf7a3a046f2a14e1fb94a4b0b58
Autor:
Jing Li, Jordan T White, Harry Saavedra, James O Wrabl, Hesam N Motlagh, Kaixian Liu, James Sowers, Trina A Schroer, E Brad Thompson, Vincent J Hilser
Publikováno v:
eLife, Vol 6 (2017)
Intrinsically disordered proteins (IDPs) present a functional paradox because they lack stable tertiary structure, but nonetheless play a central role in signaling, utilizing a process known as allostery. Historically, allostery in structured protein
Externí odkaz:
https://doaj.org/article/81a4ece1461a4f0e95dcde41379da803
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 10, p e1003247 (2013)
An algorithm is presented that returns the optimal pairwise gapped alignment of two sets of signed numerical sequence values. One distinguishing feature of this algorithm is a flexible comparison engine (based on both relative shape and absolute simi
Externí odkaz:
https://doaj.org/article/42a7d30547e84d79aa5f7cf279270c4d
Autor:
James O Wrabl, Vincent J Hilser
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 3, p e1000722 (2010)
Accumulated experimental observations demonstrate that protein stability is often preserved upon conservative point mutation. In contrast, less is known about the effects of large sequence or structure changes on the stability of a particular fold. A
Externí odkaz:
https://doaj.org/article/190e2e57351544dab646b89fbfc9828d
Publikováno v:
Molecular biology and evolution. 39(3)
Protein stability is a fundamental molecular property enabling organisms to adapt to their biological niches. How this is facilitated and whether there are kingdom specific or more general universal strategies are unknown. A principal obstacle to add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ebadc7c1dc2496f6792dd68ae665ef
https://pubmed.ncbi.nlm.nih.gov/35038744
https://pubmed.ncbi.nlm.nih.gov/35038744
“Metamorphic” proteins challenge state-of-the-art structure prediction methods reliant on amino acid similarity. Unfortunately, this obviates a more effective thermodynamic approach necessary to properly evaluate the impact of amino acid changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21d6158ae716b96e9ffb64f5d758a20a
https://doi.org/10.1101/2021.11.16.468851
https://doi.org/10.1101/2021.11.16.468851
Publikováno v:
Journal of the American Chemical Society. 141:10821-10829
High fidelity human mitochondrial DNA polymerase (Pol γ) contains two active sites, a DNA polymerization site (pol) and a 3′−5′ exonuclease site (exo) for proofreading. Although separated by 35 Å, coordination between the pol and exo sites is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f6453c435ee4e8639402761a60432d
https://doi.org/10.1021/jacs.9b04655
https://doi.org/10.1021/jacs.9b04655
Autor:
James Rives, E. Brad Thompson, Jordan T. White, James O. Wrabl, Vincent J. Hilser, Marla E. Tharp
Publikováno v:
Biochemistry. 60(21)
Tumor susceptibility gene 101 (TSG101) is involved in endosomal maturation and has been implicated in the transcriptional regulation of several steroid hormone receptors, although a detailed characterization of such regulation has yet to be conducted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9789f035891e5812540caef229a551c6
https://pubmed.ncbi.nlm.nih.gov/34009973
https://pubmed.ncbi.nlm.nih.gov/34009973
Publikováno v:
Biophys J
Defining the role of intrinsic disorder in proteins in the myriad of biological processes with which it is involved represents a significant goal in modern biophysics. Toward this end, NMR is uniquely suited for molecular studies of dynamic and disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5945ee7e34f23b37e948e05950418e
https://europepmc.org/articles/PMC8390865/
https://europepmc.org/articles/PMC8390865/
Autor:
Srona Sengupta, Robert F. Siliciano, Janet D. Siliciano, Steven G. Deeks, Andrew E. Timmons, Josephine Zhang, Scheherazade Sadegh-Nasseri, Weiming Yang, Tatiana Boronina, Rebecca Hoh, Jeanna Yu, James O. Wrabl, Aeryon Kim, Robert N. Cole, Madison C. Reed, Robin A. Welsh
Publikováno v:
SSRN Electronic Journal.
Distinct CD4+T cell epitopes have been associated with spontaneous control of HIV-1 replication, but analysis of antigen-dependent factors that influence epitope selection is lacking. To examine these factors, we used a cell-free antigen processing s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9473a686fb33ec42f4775245b8b4a2c
https://doi.org/10.2139/ssrn.3956653
https://doi.org/10.2139/ssrn.3956653