Zobrazeno 1 - 10
of 264
pro vyhledávání: '"James O, McNamara"'
Autor:
Colin W. K. Rosman, Francisco Romero Pastrana, Girbe Buist, Marjolein Heuker, Marleen van Oosten, James O. McNamara, Gooitzen M. van Dam, Jan Maarten van Dijl
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Abstract The key to effective treatment of bacterial infections is a swift and reliable diagnosis. Current clinical standards of bacterial diagnosis are slow and laborious. There are several anatomical imaging modalities that can detect inflammation,
Externí odkaz:
https://doaj.org/article/3e4436b1ed98469994c29d6d5c4271b4
Autor:
Sven Kruspe, David D. Dickey, Kevin T. Urak, Giselle N. Blanco, Matthew J. Miller, Karen C. Clark, Elliot Burghardt, Wade R. Gutierrez, Sneha D. Phadke, Sukriti Kamboj, Timothy Ginader, Brian J. Smith, Sarah K. Grimm, James Schappet, Howard Ozer, Alexandra Thomas, James O. McNamara, II, Carlos H. Chan, Paloma H. Giangrande
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss , Pp 542-557 (2017)
A challenge for circulating tumor cell (CTC)-based diagnostics is the development of simple and inexpensive methods that reliably detect the diverse cells that make up CTCs. CTC-derived nucleases are one category of proteins that could be exploited t
Externí odkaz:
https://doaj.org/article/0ebf681e427840ed926a8dc7f4b6acf9
Autor:
Nodar Makharashvili, James O. McNamara
Faster, and simpler methods that determine the susceptibility of bacterial pathogens to antibiotics are needed to enable more effective treatment of bacterial infections and reduce the overuse of antibiotics. Here, we demonstrate a simple method for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::419795bba216ba96ef6d9a8eec72fe61
https://doi.org/10.1101/2022.11.29.518369
https://doi.org/10.1101/2022.11.29.518369
Autor:
Twyman Roy E, Jerome Engel, Pavel Klein, Marc A. Dichter, Sergiusz Jóźwiak, James O. McNamara, Adam L. Hartman, Martina Bebin, Jacqueline A. French, Paul M. Vespa
Publikováno v:
Epilepsia Open
Epilepsia Open, Vol 6, Iss 3, Pp 483-492 (2021)
Epilepsia Open, Vol 6, Iss 3, Pp 483-492 (2021)
This is a summary report of clinical and regulatory issues discussed at the 2018 NINDS workshop, entitled “Accelerating Therapies for Antiepileptogenesis and Disease Modification.” The intent of the workshop was to optimize and accelerate develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b1c25037a6d5acafbf72dd9df27dfd
http://europepmc.org/articles/PMC8408600
http://europepmc.org/articles/PMC8408600
Autor:
Nodar Makharashvili, James O. McNamara
Methods that enable rapid detection of SARS-CoV-2 provide valuable tools for detecting and controlling Covid-19 outbreaks and also facilitate more effective treatment of infected individuals. The predominant approaches developed use PCR to detect vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8895396a56646a839d1e66fbb4d50323
https://doi.org/10.1101/2022.05.06.490915
https://doi.org/10.1101/2022.05.06.490915
Autor:
James O. McNamara, Aloysius J. Klingelhutz, Luiza I. Hernandez, Frank J. Hernandez, Katie S. Flenker, Paloma H. Giangrande
Publikováno v:
Pharmaceuticals, Vol 6, Iss 3, Pp 295-319 (2013)
Recent clinical trials of small interfering RNAs (siRNAs) highlight the need for robust delivery technologies that will facilitate the successful application of these therapeutics to humans. Arguably, cell targeting by conjugation to cell-specific li
Externí odkaz:
https://doaj.org/article/f773cea52f994c0ea7b0a497835076d8
Autor:
Elliot L Burghardt, Katie S Flenker, Karen C Clark, Jeff Miguel, Dilek Ince, Patricia Winokur, Bradley Ford, James O McNamara
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157234 (2016)
S. aureus bacteremia (SAB) is a common condition with high rates of morbidity and mortality. Current methods used to diagnose SAB take at least a day, and often longer. Patients with suspected bacteremia must therefore be empirically treated, often u
Externí odkaz:
https://doaj.org/article/7bb70fec38d24ead8c03b5e17f46c7ff
Publikováno v:
eNeuro
Insight into the cellular and circuit mechanisms underlying development of temporal lobe epilepsy (TLE) will provide a foundation for improved therapies. We studied a model in which an episode of prolonged seizures is followed by recovery lasting two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3056aaedf58e2c9979302fd77cb99c
https://pubmed.ncbi.nlm.nih.gov/34949685
https://pubmed.ncbi.nlm.nih.gov/34949685
Publikováno v:
Journal of Neurophysiology. 121:609-619
Hippocampal mossy fiber axons simultaneously activate CA3 pyramidal cells and stratum lucidum interneurons (SLINs), the latter providing feedforward inhibition to control CA3 pyramidal cell excitability. Filopodial extensions of giant boutons of moss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63cdd8706f7ff52d947f9bfb235d89d
https://doi.org/10.1152/jn.00669.2018
https://doi.org/10.1152/jn.00669.2018
Autor:
Megan R Kiedrowski, Heidi A Crosby, Frank J Hernandez, Cheryl L Malone, James O McNamara, Alexander R Horswill
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95574 (2014)
Staphylococcus aureus is a prominent bacterial pathogen that causes a diverse range of acute and chronic infections. Recently, it has been demonstrated that the secreted nuclease (Nuc) enzyme is a virulence factor in multiple models of infection, and
Externí odkaz:
https://doaj.org/article/6662a4a8c6b748718bb206d5b1f781bf