Zobrazeno 1 - 10 of 18 pro vyhledávání: '"James O, Jones"'
1
Akademický článek
High-resolution and highly accelerated MRI T2 mapping as a tool to characterise renal tumour subtypes and grades
Autor: Ines Horvat-Menih, Hao Li, Andrew N. Priest, Shaohang Li, Andrew B. Gill, Iosif A. Mendichovszky, Susan T. Francis, Anne Y. Warren, Brent O’Carrigan, Sarah J. Welsh, James O. Jones, Antony C. P. Riddick, James N. Armitage, Thomas J. Mitchell, Grant D. Stewart, Ferdia A. Gallagher
Publikováno v: European Radiology Experimental, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract Background Clinical imaging tools to probe aggressiveness of renal masses are lacking, and T2-weighted imaging as an integral part of magnetic resonance imaging protocol only provides qualitative information. We developed high-resolution and
Externí odkaz: https://doaj.org/article/b6c4ff0758a645e8b1e1748405028287
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2
Akademický článek
Multiarm, non-randomised, single-centre feasibility study—investigation of the differential biology between benign and malignant renal masses using advanced magnetic resonance imaging techniques (IBM-Renal): protocol
Autor: Thomas J Mitchell, Hao Li, Grant D Stewart, Anne Y Warren, James N Armitage, Ferdia A Gallagher, Mary A McLean, Andrew N Priest, Andrew B Gill, Iosif Mendichovszky, João Duarte, Ines Horvat-Menih, Maria Jesus Zamora-Morales, Marta Wylot, Joshua Kaggie, Alixander S Khan, Matthew J Locke, Sarah J Welsh, James O Jones
Publikováno v: BMJ Open, Vol 14, Iss 10 (2024)
Introduction Localised renal masses are an increasing burden on healthcare due to the rising number of cases. However, conventional imaging cannot reliably distinguish between benign and malignant renal masses, and renal mass biopsies are unable to c
Externí odkaz: https://doaj.org/article/90752ec8113d439d8fdb872d49956c6c
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3
Akademický článek
Microenvironmental modulation of the developing tumour: an immune‐stromal dialogue
Autor: James O. Jones, William M. Moody, Jacqueline D. Shields
Publikováno v: Molecular Oncology, Vol 15, Iss 10, Pp 2600-2633 (2021)
Successful establishment of a tumour relies on a cascade of interactions between cancer cells and stromal cells within an evolving microenvironment. Both immune and nonimmune cellular components are key factors in this process, and the individual pla
Externí odkaz: https://doaj.org/article/2f05306dc4d14f25b63049fced56da83
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4
Akademický článek
Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth
Autor: Hafsa Munir, James O. Jones, Tobias Janowitz, Markus Hoffmann, Maximilien Euler, Carla P. Martins, Sarah J. Welsh, Jacqueline D. Shields
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The tumor microenvironment is composed of many cell types that crosstalk to modulate local immunity. Here the authors show that Amyloid β proteins from cancer-associated fibroblasts (CAF) induce neutrophil extracellular trap (NET) production by neut
Externí odkaz: https://doaj.org/article/2556fc9e34b0446f9be86ba29dd43111
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6
Microenvironmental modulation of the developing tumour: an immune‐stromal dialogue
Autor: James O. Jones, William M. Moody, Jacqueline D. Shields
Publikováno v: Molecular Oncology
Molecular Oncology, Vol 15, Iss 10, Pp 2600-2633 (2021)
Successful establishment of a tumour relies on a cascade of interactions between cancer cells and stromal cells within an evolving microenvironment. Both immune and nonimmune cellular components have key roles in this process. Here, we review the maj
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2549dcf7cc1285d15abe593525eb69
https://doi.org/10.1002/1878-0261.12773
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9
Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth
Autor: Maximilien Euler, Sarah J. Welsh, James O. Jones, Carla P. Martins, Tobias Janowitz, Hafsa Munir, Jacqueline D. Shields, Markus H. Hoffmann
Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Tumors consist of cancer cells and a network of non-cancerous stroma. Cancer-associated fibroblasts (CAF) are known to support tumorigenesis, and are emerging as immune modulators. Neutrophils release histone-bound nuclear DNA and cytotoxic granules
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a40f8072dc37af484a1d38110b36fd
https://www.repository.cam.ac.uk/handle/1810/316869
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10
Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia
Autor: David A. Tuveson, Christine Feig, Stephen O'Rahilly, Brendan McKenna, Richard J.B. Wells, Otavia L. Caballero, Andrew Deonarine, Kevin M. Brindle, Scott K. Lyons, Qi Zhao, James O. Jones, Edward W. Roberts, Anthony P. Coll, Alice E. Denton, Marion Espéli, Sarah A. Teichmann, Rachel Larder, Matthew Kraman, Douglas T. Fearon
Publikováno v: The Journal of Experimental Medicine
Ablation of stromal cells expressing fibroblast activation protein-α (FAP) results in cachexia and anemia, and loss of these cells is seen in transplantable tumor models.
Fibroblast activation protein-α (FAP) identifies stromal cells of mesenc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe8309cbf9bfc46c856440686aad70d
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