Zobrazeno 1 - 7
of 7
pro vyhledávání: '"James O'Prey"'
Autor:
Valentin J. A. Barthet, Michaela Mrschtik, Elzbieta Kania, David G. McEwan, Dan Croft, James O'Prey, Jaclyn S. Long, Kevin M. Ryan
Publikováno v:
The FEBS journal. 289(13)
Macroautophagy is a membrane-trafficking process that delivers cytoplasmic material to lysosomes for degradation. The process preserves cellular integrity by removing damaged cellular constituents and can promote cell survival by providing substrates
Autor:
Barbara Zunino, Valentin J.A. Barthet, Martina Brucoli, Christos Kiourtis, James O'Prey, Stephanie May, Kevin M. Ryan, Jaclyn S. Long, Marcus J. G. W. Ladds, Christoph Nössing, Alice D. Baudot, Miryam Müller, Thomas G. Bird, Colin Nixon
Publikováno v:
Barthet, V J A, Brucoli, M, Ladds, M J G W, Nossing, C, Kiourtis, C, Baudot, A, O'Prey, J, Zunino, B, Müller, M, May, S, Nixon, C, Long, J S, Bird, T G & Ryan, K M 2021, ' Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver ', Science Advances . https://doi.org/10.1126/sciadv.abf9141
Science Advances
Science Advances
Autophagy represses YAP/TAZ-dependent hepatocyte dedifferentiation into liver progenitor cells to prevent tumorigenesis.
Hepatocellular carcinoma (HCC) is driven by repeated rounds of inflammation, leading to fibrosis, cirrhosis, and, ultimately
Hepatocellular carcinoma (HCC) is driven by repeated rounds of inflammation, leading to fibrosis, cirrhosis, and, ultimately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066e61e3989c4c8c82a7f7473d74f3bf
https://eprints.gla.ac.uk/238882/1/238882.pdf
https://eprints.gla.ac.uk/238882/1/238882.pdf
Autor:
James O'Prey, Barbara Zunino, Valentin J.A. Barthet, Alexis Maximilien Bachmann, Pablo Sierra Gonzalez, Laurence Y. Lao, Elżbieta Kania, Jean-Philippe Parvy, Robin Macintosh, Stephen W.G. Tait, Kevin N. Ryan, Jaclyn S. Long, Margaret O'Prey, Jonathan Lopez, Florian Beaumatin, Colin Nixon
Publikováno v:
Molecular Cell 1 (76), 163-176. (2019)
Molecular Cell
Molecular Cell, 2019, 76 (1), pp.163-176. ⟨10.1016/j.molcel.2019.07.021⟩
Molecular Cell
Molecular Cell, 2019, 76 (1), pp.163-176. ⟨10.1016/j.molcel.2019.07.021⟩
Summary Sensing nutrient availability is essential for appropriate cellular growth, and mTORC1 is a major regulator of this process. Mechanisms causing mTORC1 activation are, however, complex and diverse. We report here an additional important step i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00859956f51f3be2edde24b0ac146b76
http://prodinra.inra.fr/record/492244
http://prodinra.inra.fr/record/492244
Autor:
Andrew Oberst, João F. Passos, Kevin M. Ryan, Ann P. Wheeler, James Chapman, Giovanni Quarato, Stephen W.G. Tait, Joel S. Riley, Hiromi Sesaki, Leo M. Carlin, Matthew Pearson, James O'Prey, Jonathan Lopez
During apoptosis, pro-apoptotic BAX and BAK are activated, causing mitochondrial outer membrane permeabilisation (MOMP), caspase activation and cell death. However, even in the absence of caspase activity, cells usually die following MOMP. Such caspa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72657768778ce3738807afa432366e40
Autor:
Owen J. Sansom, Darren Ennis, Joanne Edwards, James O'Prey, Antonia K. Roseweir, Aoisha Hoyle, S. Cardaci, Kevin M. Ryan, Gaurav Malviya, Alice D. Baudot, Colin Nixon, Agata Mrowinska, Barbara Zunino, Jun-ichi Sakamaki, Shona Ritchie, Gillian M. Mackay, Iain A. McNeish, Elżbieta Kania, David Millan, Florian Beaumatin, Valentin J.A. Barthet, Pablo Sierra Gonzalez
Publikováno v:
Nature. 563(7733)
It is now well established that tumours undergo changes in cellular metabolism1. As this can reveal tumour cell vulnerabilities and because many tumours exhibit enhanced glucose uptake2, we have been interested in how tumour cells respond to differen
Autor:
Daniel Hochhauser, James O'Prey, Aikaterini Lampada, Kevin M. Ryan, Gyorgy Szabadkai, Paolo Salomoni
The intracellular autophagic degradative pathway can have a tumour suppressive or tumour-promoting role depending on the stage of tumour development. Upon starvation or targeting of oncogenic receptor tyrosine kinases (RTKs), autophagy is activated o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ac95806da7854ba16b42e2ab1ee908
https://europepmc.org/articles/PMC5442471/
https://europepmc.org/articles/PMC5442471/
Autor:
Diane Crighton, Timothy M. Palmer, Kevin M. Ryan, Jaclyn S. Long, Eyal Gottlieb, James O'Prey, Gillian M. Mackay, Liang Zheng
Publikováno v:
Molecular cell. 50(3)
Tumor cells undergo changes in metabolism to meet their energetic and anabolic needs. It is conceivable that mechanisms exist to sense these changes and link them to pathways that eradicate cells primed for cancer development. We report that the tumo