Zobrazeno 1 - 10
of 14
pro vyhledávání: '"James N. Scutt"'
Publikováno v:
Synlett. 27:151-155
trans-NH-Aziridines were prepared from aliphatic α,β-unsaturated ketones using a tertiary amine promoted reaction via in situ generated N,N-ylides. Through use of modified conditions the reaction proved to be applicable for the diastereoselective a
Autor:
Chloe R. Jenner, Andrew J. P. White, James N. Scutt, Robert D. C. Pullin, Alan Armstrong, Klement Foo
Publikováno v:
Tetrahedron: Asymmetry. 25:74-86
trans-N- Unsubstituted aziridines were synthesised (up to 77% ee) via a chiral tertiary amine-promoted nucleophilic aziridination of α,β-unsaturated ketones utilising in situ generated N – N ylides (aminimines). A wide range of chiral tertiary am
Publikováno v:
The Journal of Organic Chemistry. 72:8091-8094
Cinchona alkaloid-catalyzed reaction of ethyl glyoxylate with substituted ketenes, formed in situ, gives disubstituted beta-lactones in moderate yield and high enantiomeric excess. Subsequent azide ring opening, reduction, and ester hydrolysis allows
Autor:
James N. Scutt, Alan Armstrong
Publikováno v:
Organic Letters. 5:2331-2334
Herein we report a concise synthesis of 3-(trans-2-aminocyclopropyl)alanine, a component of belactosin A, using asymmetric alkylation of a glycine enolate in the presence of chiral phase-transfer catalysts to control the configuration at C2. Reaction
Autor:
Andrew J. P. White, Klement Foo, Robert D. C. Pullin, James N. Scutt, Alan Armstrong, Chloe R. Jenner
Publikováno v:
ChemInform. 45
Upon several tested tertiary amines quinine shows to be the best promoter for the asymmetric aziridination of α,β-unsaturated ketones.
Autor:
James N. L. Dennett, Amy L. Gillon, Katie Heslop, David J. Hyett, James S. Fleming, C. Emma Lloyd-Jones, A. Guy Orpen, Paul G. Pringle, Duncan F. Wass, James N. Scutt, Richard H. Weatherhead
Publikováno v:
Organometallics. 23:6077-6079
Nickel(II) complexes of ligands of the type Ar2PCH2PAr2 and 1,2-Ar2PC6H4PAr2 (Ar = ortho-substituted phenyl) are active catalysts for polymerization and oligomerization of ethylene.
Publikováno v:
ChemInform. 41
A new method to prepare synthetically important vinyl aziridines proceeds with complete regio- and stereoselectivity.
Publikováno v:
ChemInform. 33
Publikováno v:
The Journal of organic chemistry. 75(10)
N-Unsubstituted vinyl aziridines were synthesized via an amine-promoted regioselective nucleophilic aziridination of alpha,beta,gamma,delta-unsaturated carbonyl compounds. The reaction is completely regioselective (95: 5) for the alpha,beta-alkene an
Autor:
Waljit S. Dhillo, Stephen R. Bloom, Debabrata Roy, Emily L. Thompson, N. A. Patel, Alan Armstrong, Kevin Murphy, A. Bataveljic, N. E. White, M. A. Ghatei, Gavin A. Bewick, James N. Scutt, James Gardiner
Publikováno v:
Diabetes, obesitymetabolism. 11(3)
Background: The thyroid hormone derivative 3-iodothyronamine (T1AM), an endogenous biogenic amine, is a potent agonist of the G protein–coupled trace amine-associated receptor 1 (TAAR1). T1AM is present in rat brain, and TAAR1 is expressed in hypot