Zobrazeno 1 - 9
of 9
pro vyhledávání: '"James N. Nyariki"'
Autor:
Victoria K. Mwaeni, James N. Nyariki, Ngalla Jillani, George Omwenga, Mathew Ngugi, Alfred Orina Isaac
Publikováno v:
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Background Arsenic poisoning affects millions of people. The inorganic forms of arsenic are more toxic. Treatment for arsenic poisoning relies on chelation of extracellularly circulating arsenic molecules by 2,3-dimecaptosuccinic acid (DMSA)
Externí odkaz:
https://doaj.org/article/9bad91049757416bbce679c7f444b813
Autor:
David B. Ouko, Peris W. Amwayi, Lucy A. Ochola, Peninah M. Wairagu, Alfred Orina Isaac, James N. Nyariki
Publikováno v:
J Parasit Dis
Development of cerebral malaria (CM) is driven by parasitemia levels, harmful inflammatory response, oxidative stress and consequent breach of the blood brain barrier. Use of adjunct therapy that utilizes an antioxidant and anti-inflammatory agent al
Autor:
Kennedy W. Chepukosi, Alfred Orina Isaac, Patrick W. Okanya, James N. Nyariki, Ngalla E. Jillani
Publikováno v:
Toxicology and Environmental Health Sciences. 13:337-350
This study sought to determine whether chronic exposure to khat (Catha Edulis, Forsk) increases the vulnerability to the toxic effects of manganese (Mn2+), when co-exposed. Three (3)-week-old forty (40) Swiss albino mice were randomly divided into fo
Autor:
James N. Nyariki, Alfred Orina Isaac, Ngalla Jillani, Victoria K. Mwaeni, George Isanda Omwenga, Mathew Piero Ngugi
Publikováno v:
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-19 (2021)
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology
Background Arsenic poisoning affects millions of people. The inorganic forms of arsenic are more toxic. Treatment for arsenic poisoning relies on chelation of extracellularly circulating arsenic molecules by 2,3-dimecaptosuccinic acid (DMSA). As a ph
Autor:
Peris Amwayi, Grace Wairimu Gitau, Alfred Orina Isaac, Kipchumba Biwott, Francis Gitonga, Okanya Patrick Wafula, James N. Nyariki
Publikováno v:
Scientific African, Vol 12, Iss, Pp e00815-(2021)
Potassium cyanide (KCN) is one of the most lethal and feared poison; which devastates cellular respiration resulting in death due to hypoxia. Several antidotes exist, but most face major limitations of safety and efficacy. Moreover, there is a need f
Publikováno v:
Parasites & Vectors, Vol 14, Iss 1, Pp 1-8 (2021)
Parasites & Vectors
Parasites & Vectors
Background Cryptosporidiosis causes high morbidity and mortality in children under 2 years of age globally. The lack of an appropriate animal model that mimics the pathogenesis of disease in humans has hampered the development and testing of potentia
Autor:
Ngalla E. Jillani, Alfred Orina Isaac, Nemwel O. Nyamweya, Peris Amwayi, James N. Nyariki, Laurent Azonvide, Lucy A. Ochola, Dorcas S. Yole
Publikováno v:
Parasitology International. 71:106-120
In animal model of experimental cerebral malaria (ECM), the genesis of neuropathology is associated with oxidative stress and inflammatory mediators. There is limited progress in the development of new approaches to the treatment of cerebral malaria.
Coenzyme Q10 nullified khat-induced hepatotoxicity, nephrotoxicity and inflammation in a mouse model
Autor:
Ngalla E. Jillani, Chepukosi Kennedy, James N. Nyariki, Patrick W. Okanya, Peris Amwayi, Alfred Orina Isaac
Publikováno v:
Heliyon, Vol 6, Iss 9, Pp e04917-(2020)
Heliyon
Heliyon
Ethnopharmacological relevance The consumption of khat (Catha Edulis, Forsk) is on the rise despite the much publicized associated deleterious health effects. How chemicals present in khat, affect various physiological and biochemical processes requi
Publikováno v:
Parasitology international. 63(2)
Human African trypanosomiasis (HAT) is a tropical disease caused by two subspecies of Trypanosoma brucei, the East African variant T. b. rhodesiense and the West African variant T. b. gambiense. Melarsoprol, an organic arsenical, is the only drug use