Zobrazeno 1 - 10
of 25
pro vyhledávání: '"James N. Jacob"'
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 112:171-174
Glucose-aspirin (GA) was synthesized by conjugating aspirin (ASA) to the 3-carbon of glucose to produce a stable water-soluble aspirin derivative. The in vivo activities were compared with those of aspirin. The mouse tail flick assay showed that at 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5b9fd06409c254589d4fb51dfd0604
https://doi.org/10.1111/bcpt.12006
https://doi.org/10.1111/bcpt.12006
Autor:
James N, Jacob, Dinesh K, Badyal
Publikováno v:
Natural product communications. 9(2)
Turmeric and fish oil have been gaining interest as food supplements because of their beneficial properties. Turmeric oil contains sesquiterpenes and fish oil has eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), possessing anti-inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f9f88bb90ad551037355cc24349ea6b
https://pubmed.ncbi.nlm.nih.gov/24689297
https://pubmed.ncbi.nlm.nih.gov/24689297
Publikováno v:
Natural product communications. 8(3)
Curcumin, obtained from turmeric, has several biological properties to make it a desirable template for drug development. A lipophilic derivative of curcumin, diacetyl curcumin (DAC) and a hydrophilic derivative, diglutaryl curcumin (DGC) were synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::beee2bdba192d8a9cac48e99ce55692a
https://pubmed.ncbi.nlm.nih.gov/23678811
https://pubmed.ncbi.nlm.nih.gov/23678811
Autor:
Makio J. Tazawa, James N. Jacob
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(9)
Glucose-aspirin (GA) was synthesized by conjugating aspirin (ASA) to glucose. The water solubility and biological activity of GA was studied in comparison to aspirin. The human serum protease activity on the ester showed a slower hydrolysis rate, com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3336bda000cec05e6fa39f6a41ca82d
https://pubmed.ncbi.nlm.nih.gov/22494617
https://pubmed.ncbi.nlm.nih.gov/22494617
Publikováno v:
Journal of Medicinal Chemistry. 33:733-736
1-O-Linolenoyl-2-O-(4-aminobutyryl)-3-O-(4-vinyl-4-aminobutyryl)glycerol (LGV) was synthesized as an example of a prodrug which readily penetrates the blood-brain barrier (brain penetration index 97% +/- 15%) and releases two active substances in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c824c71c02ca90e630cd2d36b614b19c
https://doi.org/10.1021/jm00164a042
https://doi.org/10.1021/jm00164a042
Autor:
Dinesh K Badyal, James N. Jacob
Publikováno v:
Natural Product Communications. 9:1934578X1400900
Turmeric and fish oil have been gaining interest as food supplements because of their beneficial properties. Turmeric oil contains sesquiterpenes and fish oil has eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), possessing anti-inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb0785f74d329881f939bdee9286a568
https://doi.org/10.1177/1934578x1400900224
https://doi.org/10.1177/1934578x1400900224
Autor:
James N. Jacob, Masoud Toloue
Publikováno v:
Natural Product Communications. 8:1934578X1300800
The oil from turmeric (Curcuma longa) contains several sesquiterpenes with medicinal properties. The oil fractions were purified by repeated high vacuum distillations to constant boiling points and by column chromatography. The major components in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a51982012e527d6e137301448e61a18
https://doi.org/10.1177/1934578x1300800632
https://doi.org/10.1177/1934578x1300800632
Publikováno v:
Natural Product Communications. 8:1934578X1300800
The current study is directed at identifying compounds that have biological activity in the less studied oil fraction of Curcuma longa (turmeric) to treat pancreatic cancer, which has no good treatment options. Fractional distillation and chromatogra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c3bb84e41fbcb056d63fa4480e0de8d
https://doi.org/10.1177/1934578x1300800633
https://doi.org/10.1177/1934578x1300800633
Publikováno v:
Natural Product Communications. 8:1934578X1300800
Curcumin, obtained from turmeric, has several biological properties to make it a desirable template for drug development. A lipophilic derivative of curcumin, diacetyl curcumin (DAC) and a hydrophilic derivative, diglutaryl curcumin (DGC) were synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c77515364900795181b94631549cd86
https://doi.org/10.1177/1934578x1300800321
https://doi.org/10.1177/1934578x1300800321
Publikováno v:
Journal of Medicinal Chemistry. 27:659-664
Labeled and unlabeled aliphatic and steroid esters of gamma-amino[U-14C]butyric acid (GABA) were synthesized and tested for their capacity to penetrate the blood-brain barrier and for evidence of central neuropharmacological activity in rodents. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c86e0ea3b8e68cc55f45e0ad7997e08
https://doi.org/10.1021/jm00371a018
https://doi.org/10.1021/jm00371a018