Zobrazeno 1 - 10
of 79
pro vyhledávání: '"James N Sleigh"'
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 8, Pp 1653-1654 (2024)
Externí odkaz:
https://doaj.org/article/ed5f9861e96f4337bdd89b0c22b5c40d
Autor:
Maria Dimitriadi, James N Sleigh, Amy Walker, Howard C Chang, Anindya Sen, Geetika Kalloo, Jevede Harris, Tom Barsby, Melissa B Walsh, John S Satterlee, Chris Li, David Van Vactor, Spyros Artavanis-Tsakonas, Anne C Hart
Publikováno v:
PLoS Genetics, Vol 6, Iss 10, p e1001172 (2010)
Spinal Muscular Atrophy (SMA) is caused by diminished function of the Survival of Motor Neuron (SMN) protein, but the molecular pathways critical for SMA pathology remain elusive. We have used genetic approaches in invertebrate models to identify con
Externí odkaz:
https://doaj.org/article/fd85f5c608b9407a8437e26861aab3f6
Autor:
Samuele Negro, Fabio Lauria, Marco Stazi, Toma Tebaldi, Giorgia D’Este, Marco Pirazzini, Aram Megighian, Francesca Lessi, Chiara M. Mazzanti, Gabriele Sales, Chiara Romualdi, Silvia Fillo, Florigio Lista, James N. Sleigh, Andrew P. Tosolini, Giampietro Schiavo, Gabriella Viero, Michela Rigoni
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Regeneration of the neuromuscular junction (NMJ) leverages on extensive exchange of factors released from motor axon terminals (MATs), muscle fibers and perisynaptic Schwann cells (PSCs), among which hydrogen peroxide (H2O2) is a major pro-r
Externí odkaz:
https://doaj.org/article/26994f99fdf54e9a92efdf648b2d851d
Autor:
Andrew P. Tosolini, James N. Sleigh, Sunaina Surana, Elena R. Rhymes, Stephen D. Cahalan, Giampietro Schiavo
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Axonal transport ensures long-range delivery of essential cargoes between proximal and distal compartments, and is needed for neuronal development, function, and survival. Deficits in axonal transport have been detected at pre-symptomatic st
Externí odkaz:
https://doaj.org/article/07970240dea84f048f2259473a61235f
Autor:
Alan Mejia Maza, Seth Jarvis, Weaverly Colleen Lee, Thomas J. Cunningham, Giampietro Schiavo, Maria Secrier, Pietro Fratta, James N. Sleigh, Elizabeth M. C. Fisher, Carole H. Sudre
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The neuromuscular junction (NMJ) is the peripheral synapse formed between a motor neuron axon terminal and a muscle fibre. NMJs are thought to be the primary site of peripheral pathology in many neuromuscular diseases, but innervation/denerv
Externí odkaz:
https://doaj.org/article/3ff0e26ea9ca4cddb08257a5dd74ce5e
Autor:
James N. Sleigh, Andrew P. Tosolini, David Gordon, Anny Devoy, Pietro Fratta, Elizabeth M.C. Fisher, Kevin Talbot, Giampietro Schiavo
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3655-3662.e2 (2020)
Summary: Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease resulting from a complex interplay between genetics and environment. Impairments in axonal transport have been identified in several ALS models, but in viv
Externí odkaz:
https://doaj.org/article/ceb14eaab60846eea149101a166e9a4c
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The mechanism by which dominantly inherited mutations in the housekeeping gene GARS, which encodes glycyl-tRNA synthetase (GlyRS), mediate selective peripheral nerve toxicity resulting in Charcot-Marie-Tooth disease type 2D (CMT2D) is still
Externí odkaz:
https://doaj.org/article/de8e9fb7f31545f992c90a302df4673a
Autor:
James N. Sleigh, David Villarroel-Campos, Sunaina Surana, Tahmina Wickenden, Yao Tong, Rebecca L. Simkin, Jose Norberto S. Vargas, Elena R. Rhymes, Andrew P. Tosolini, Steven J. West, Qian Zhang, Xiang-Lei Yang, Giampietro Schiavo
Publikováno v:
JCI Insight. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fd12d767bd75b4e7c0724b9a0953cce
https://doi.org/10.1172/jci.insight.157191
https://doi.org/10.1172/jci.insight.157191
Autor:
Elena R. Rhymes, Rebecca L. Simkin, Sunaina Surana, Yao Tong, David Villarroel-Campos, Xiang-Lei Yang, Giampietro Schiavo, James N. Sleigh
Charcot-Marie-Tooth disease (CMT) is a form of genetic peripheral neuropathy caused by mutations in many functionally diverse genes. The aminoacyl-tRNA synthetase (ARS) enzymes, which charge amino acids to partner tRNAs for protein synthesis, represe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a6083e2dc481ea53c82c6a56bcae77b
https://doi.org/10.1101/2023.04.09.536152
https://doi.org/10.1101/2023.04.09.536152
Publikováno v:
Neuronal Signaling. 7
Axonal transport is the essential process by which neurons actively traffic a variety of cargoes between the cell soma and axon terminals. Accordingly, dysfunctional axonal transport is linked to many nervous system conditions. Therefore, being able
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a0ecc2c7f406a4cb53c4136da4ed847
https://doi.org/10.1042/ns20220098
https://doi.org/10.1042/ns20220098