Zobrazeno 1 - 10
of 71
pro vyhledávání: '"James N, Livingston"'
Autor:
Dario R. Roque, Lu Zhang, Weiya Z. Wysham, Jianjun Han, Wenchuan Sun, Yajie Yin, James N. Livingston, Ken W. Batchelor, Chunxiao Zhou, Victoria L. Bae-Jump
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
ObjectivesAnti-diabetic biguanide drugs such as metformin may have anti-tumorigenic effects by behaving as AMPK activators and mTOR inhibitors. Metformin requires organic cation transporters (OCTs) for entry into cells, and NT-1044 is an AMPK activat
Externí odkaz:
https://doaj.org/article/d5fdb5755f304952abf348c1f42431bd
Autor:
Kenneth Batchelor, Peter Arner, James N. Livingston, Mikael Rydén, Agné Kulyté, Jurga Laurencikiene
Publikováno v:
Diabetes, Obesity and Metabolism. 20:2416-2425
AIMS. The anti-lipolytic actions of biguanides in fat cells may contribute to their antidiabetic effects. Biguanides use membrane transporters to act intracellularly. The transporters involved in mediating the antilipolytic effect in human fat cells
Publikováno v:
Diabetes. 68
Metformin, a frontline treatment for T2D, is a BIG drug with low potency and limiting side effects. To overcome these limitations, we examined a compound library of 265 novel BIGs by screening these agents against five organic cationic transporters (
Publikováno v:
Diabetes. 68
Metformin, the most prescribed drug for T2D, has significant deficiencies in potency, pharmacokinetics (PK) and safety, especially in patients with kidney disease. Despite these deficiencies no improvements have been made to the biguanide (BIG) drug
Autor:
Nicole Barucci, Herbert Ogutu, Laurel Sweet, Ronda Ott-Morgan, Louis-David Cantin, Yaxin Li, James N. Livingston, Philip Wickens, Lei Zhu, Sidney X. Liang, Jennifer Burke, Timothy B. Lowinger, Zhonghua Zhang, Bullock William H, Michelle Daly, Robert Schoenleber, Lynn Decarr, Steven Magnuson, Adrian Tersteegen, Ann Gore-Willse, Ellalahewage Kumarasinghe, Alan Olague, Jian Zhu, Marina Breuhaus, David E. Gunn, Margit L. MacDougall, Thomas H. Claus, Helana Hoover-Litty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2869-2873
Modulation of cAMP levels has been linked to insulin secretion in preclinical animal models and in humans. The high expression of PDE-10A in pancreatic islets suggested that inhibition of this enzyme may provide the necessary modulation to elicit inc
Autor:
Jeffrey Shapiro, Bullock William H, Christine Keiper, Manami Tsutsumi, Ling Yang, Roger B Clark, Xin Ma, Sidney X. Liang, James N. Livingston, Louis-David Cantin, Christiana Iwuagwu, Frederick Ehrgott, Jeffrey Johnson, Thomas H. Claus, Ken Boakye, Herbert Ogutu, Christopher Town, Michael Burns, Michelle Daly, Robert Schoenleber, Fernando E. delaCruz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1056-1061
Modulation of PPAR activities represents an attractive approach for the treatment of diabetes with associated cardiovascular complications. The indanylacetic acid structural motif has proven useful in the generation of potent and tunable PPAR ligands
Autor:
Stephanie L. Yung, Xianbu Peng, Yin Liang, Hongxing Chen, Fernando Dela Cruz, Ling Yang, Clark Pan, Jian Zhu, James N. Livingston, Thomas H. Claus, Sarah Hamren, Manami Tsutsumi, Yaxin Li
Publikováno v:
Diabetes. 51:1453-1460
Pituitary adenylate cyclase—activating peptide (PACAP) and vasoactive intestinal peptide (VIP) activate two shared receptors, VPAC1 and VPAC2. Activation of VPAC1 has been implicated in elevating glucose output, whereas activation of VPAC2 may be i
Publikováno v:
Journal of Lipid Research, Vol 15, Iss 1, Pp 26-32 (1974)
This study is concerned with potential modifications of large fat cells from adult rats (400–450 g) that make them resistant to stimulation by glucagon. The lipolytic capacity and 125I-labeled glucagon-binding capability of these cells were compare
Externí odkaz:
https://doaj.org/article/dd3c84de882c42a7a2748f6159f1cb18
Publikováno v:
Journal of Lipid Research, Vol 15, Iss 1, Pp 33-38 (1974)
The role of phosphodiesterase in glucagon resistance of large adipocytes was investigated. A comparison was made of phosphodiesterase activities of homogenates prepared from isolated small (mean diameter ≃ 45 μm) and large (mean diameter ≃ 78 μ
Externí odkaz:
https://doaj.org/article/23d235fc6ccb41159a9415dc56c22099
Autor:
Jiang-Ming Ren, Ann C. Davis, Jian Zhu, Daniel U. Rabin, James N. Livingston, Ann R. Gore-Willse, Joanne M. Arrandale, Sandra Rocks
Publikováno v:
Journal of Biological Chemistry. 271:21353-21358
Syp is a protein tyrosine phosphatase implicated in insulin and growth factor signaling. To evaluate the role of syp in insulin's regulation of plasma glucose, we generated knockout mice. Homozygous knockout mice die prior to day 10.5 of embryonic de