Zobrazeno 1 - 10
of 340
pro vyhledávání: '"James Mu"'
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez-Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/d6d3fdb3039843b9b530ac94e6eb34d2
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez-Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Insulin analogs have been developed to treat diabetes with focus primarily on improving the time action profile without affecting ligand-receptor interaction or functional selectivity. As a result, inherent liabilities (e.g. hypoglycemia) of
Externí odkaz:
https://doaj.org/article/12bfc20a079d44f5b507280558359df6
Autor:
Kingshuk Dutta, Ritam Das, Jing Ling, Rafael Mayoral Monibas, Ester Carballo-Jane, Ahmet Kekec, Danqing Dennis Feng, Songnian Lin, James Mu, Robert Saklatvala, S. Thayumanavan, Yingkai Liang
Publikováno v:
ACS Omega, Vol 5, Iss 28, Pp 17531-17542 (2020)
Externí odkaz:
https://doaj.org/article/e07bb7861fcc44ce9fd240665f45f633
Autor:
Olivia Wendling, Didier Hentsch, Hugues Jacobs, Nicolas Lemercier, Serge Taubert, Fabien Pertuy, Jean-Luc Vonesch, Tania Sorg, Michela Di Michele, Laurent Le Cam, Thomas Rosahl, Ester Carballo-Jane, Mindy Liu, James Mu, Manuel Mark, Yann Herault
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 767 (2021)
3D imaging in animal models, during development or in adults, facilitates the identification of structural morphological changes that cannot be achieved with traditional 2D histological staining. Through the reconstruction of whole embryos or a regio
Externí odkaz:
https://doaj.org/article/aa53525f25c64b5e83aa2c58474332ef
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122012 (2015)
Insulin resistance is the key feature of type 2 diabetes and is manifested as attenuated insulin receptor (IR) signaling in response to same levels of insulin binding. Several small molecule IR activators have been identified and reported to exhibit
Externí odkaz:
https://doaj.org/article/180826ff9bef4585b00a3806018c4937
Autor:
Eric S Muise, Sandra Souza, An Chi, Yejun Tan, Xuemei Zhao, Franklin Liu, Qing Dallas-Yang, Margaret Wu, Tim Sarr, Lan Zhu, Hongbo Guo, Zhihua Li, Wenyu Li, Weiwen Hu, Guoqiang Jiang, Cloud P Paweletz, Ronald C Hendrickson, John R Thompson, James Mu, Joel P Berger, Huseyin Mehmet
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73011 (2013)
FGF21 is a novel secreted protein with robust anti-diabetic, anti-obesity, and anti-atherogenic activities in preclinical species. In the current study, we investigated the signal transduction pathways downstream of FGF21 following acute administrati
Externí odkaz:
https://doaj.org/article/a4a3fe9c712544778c536bbaafd1595d
Autor:
James Mu, Sajjad A Qureshi, Edward J Brady, Eric S Muise, Mari Rios Candelore, Guoqiang Jiang, Zhihua Li, Margaret S Wu, Xiaodong Yang, Qing Dallas-Yang, Corey Miller, Yusheng Xiong, Ronald B Langdon, Emma R Parmee, Bei B Zhang
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49572 (2012)
Hyperglucagonemia is implicated in the pathophysiology of hyperglycemia. Antagonism of the glucagon receptor (GCGR) thus represents a potential approach to diabetes treatment. Herein we report the characterization of GRA1, a novel small-molecule GCGR
Externí odkaz:
https://doaj.org/article/d41be1e4e3c94bbbb634399a73d5972e
Autor:
Dmitri A. Pissarnitski, Ahmet Kekec, Lin Yan, Yuping Zhu, Danqing D. Feng, Pei Huo, Christina Madsen-Duggan, Christopher R. Moyes, Ravi P. Nargund, Terri Kelly, Xiaoping Zhang, Ester Carballo-Jane, Judith Gorski, Peter Zafian, Mo Qatanani, Niels Kaarsholm, Fanyu Meng, Xiujuan Jia, Keun-Joong Lee, Weixun Wang, Sherrie Xu, Michael J. Hohn, Michael J. Iammarino, Mark A. McCoy, Grace A. Okoh, Yingkai Liang, Scott A. Hollingsworth, Mark D. Erion, David E. Kelley, Robert M. Garbaccio, Amy Zhang, James Mu, Songnian Lin
Publikováno v:
Journal of Medicinal Chemistry. 65:5593-5605
We have identified a series of novel insulin receptor partial agonists (IRPAs) with a potential to mitigate the risk of hypoglycemia associated with the use of insulin as an antidiabetic treatment. These molecules were designed as dimers of native in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159d29e98accab17d5d9616e44812b0d
https://doi.org/10.1021/acs.jmedchem.1c02073
https://doi.org/10.1021/acs.jmedchem.1c02073
Autor:
Harrison D. Collier-Bain, Frankie F. Brown, Adam J. Causer, Lois Ross, Daniela Rothschild-Rodriguez, Noah Browne, Rachel Eddy, Kirstie L. Cleary, Juliet C. Gray, Mark S. Cragg, Sally Moore, James Murray, James E. Turner, John P. Campbell
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Complement-dependent cytotoxicity (CDC) is a primary mechanism-of-action of monoclonal antibody (mAb) immunotherapies used to treat haematological cancers, including rituximab and daratumumab. However, mAb efficacy may be limited by reduced
Externí odkaz:
https://doaj.org/article/05c09f05aa634c8b8fd55a17bc92a64f
Autor:
Zelipha N. Kabubii, James Mucunu Mbaria, Peter Mbaabu Mathiu, John Muraba Wanjohi, Evans Nyaega Nyaboga
Publikováno v:
Clinical Phytoscience, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Background Diabetes mellitus is a metabolic disease characterized by prolonged elevated blood glucose levels. It is a common health problem with a high mortality and morbidity to the human race. A number of medicinal plants such as rosemary
Externí odkaz:
https://doaj.org/article/c6922dd585694979a859a3ae7d58d541