Výsledky vyhledávání - "James Michael Walker Stattel"

Structural studies by H NMR of a prototypic α-helical peptide (LYQELQKLTQTLK) and homologs in trifluoroethanol/water and on sodium dodecyl sulfate micelles

Autor: Minzhen Xu, John K. Young, George E. Wright, Donald J. Nelson, Frank Marí, Joseph Gambino, Nikki M. Clemente, Robert E. Humphreys, James Michael Walker Stattel

Publikováno v: The Journal of Peptide Research. 50:122-131

The 1H NMR-determined structure and dynamics of a synthetic, amphiphilic alpha-helical peptide, PH-1.0 (LYQELQKLTQTLK), and several homologs were compared in 50% trifluoroethanol-d2 (TFE-d2)/H20 and in sodium dodecyl-d25 sulfate (SDS-d25) micelles. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90c5c72caf3f12487d94c342f34697fb
https://doi.org/10.1111/j.1399-3011.1997.tb01177.x

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Nucleoside carbonyl(di- and triphosphates)Electronic supplementary information (ESI) available: figures showing the time course of the reaction of the phosphoroimidazolidate of BuPdGMP (2) with PCOP (6), and reaction of N-methylphosphoroimidazolate of BuPdGMP (4) with 1 eq. of 6. See http://www.rsc.org/suppdata/p1/b1/b102467c

Autor: Ivan B. Yanachkov, George E. Wright, James Michael Walker Stattel

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :3080-3084

The first examples of nucleoside di- and triphosphates containing the electrophilic and potentially reactive carbonyl group in place of a phosphoanhydride oxygen are reported, using the DNA polymerase inhibitors N2-(4-butylphenyl)-2′-deoxyguanosine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60b7981a6a7a3056b7cd9aab93db774c
https://doi.org/10.1039/b102467c

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Synthesis and Biochemical Study of N2-(p-n-Butylphenyl)-2′-deoxyguanosine 5′-(α,β-imido)triphosphate (BuPdGMPNHPP): A Non-Substrate Inhibitor of B Family DNA Polymerases

Autor: Ivan B. Yanachkov, George E. Wright, James Michael Walker Stattel

Publikováno v: Nucleosides and Nucleotides. 17:1505-1513

BuPdGMPNHPP was synthesized and assayed as a non-incorporable inhibitor of B family DNA polymerases. The derivative was synthesized by preparation of the imidophosphorane of BuPdG followed by reaction with orthophosphate using the imidazolide method.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed6dd9d064c501120b56bbc19c124eb
https://doi.org/10.1080/07328319808003483

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N2-(p-n-Octylphenyl)dGTP: Synthesis and Inhibitory Activity Against DNA Polymerases

Autor: Silvio Spadari, James Michael Walker Stattel, Naseema N. Khan, Joseph Gambino, Janis Jansons, George E. Wright, Annalisa Verri, Federico Focher

Publikováno v: Nucleosides and Nucleotides. 15:669-682

N2-(p-n-Octylphenyl)-2′-deoxyguanosine 5′-triphosphate (OctPdGTP)has been synthesized chemically. OctPdGTP inhibited DNA polymerases (pol) α, δ and ∊ from calf thymus, with moderate selectivity for pol α. Mechanistic studies on pol α and ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a30b4bb0fd3d7b785595dd439afa4c3
https://doi.org/10.1080/07328319608002414

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ChemInform Abstract: Nucleoside Carbonyl(di- and triphosphates)

Autor: George E. Wright, Ivan B. Yanachkov, James Michael Walker Stattel

Publikováno v: ChemInform. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25d836b3ac1731f9d0cdf23bb7b595d6
https://doi.org/10.1002/chin.200211191

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