Zobrazeno 1 - 2
of 2
pro vyhledávání: '"James Michael Pauff"'
Autor:
Lindsey Elizabeth Roeker, Alvaro Jose Alencar, Guru Subramanian Guru Murthy, Marc Steven Hoffmann, John M. Pagel, Vishalkumar Patel, James Michael Pauff, Pier Luigi Zinzani, Steven Le Gouill, Anthony Mato, Wojciech Jurczak
Publikováno v:
Journal of Clinical Oncology. 40:TPS7582-TPS7582
TPS7582 Background: B-cell lymphoma 2 (BCL2) is a key regulator of apoptosis and provides protection from cell death in many hematologic malignancies. LOXO-338 is an orally bioavailable small molecule inhibitor of BCL2, developed to achieve selectivi
Autor:
Filip Janku, James J. Harding, Masafumi Ikeda, Rebecca Tupper, Matthew P. Hanley, Mary Linton B. Peters, James Michael Pauff, Carrie E. Furin, Kurt A. Jaeckle, Rachna T. Shroff, Elizabeth G. Hill, Toshio Shimizu, Lipika Goyal, James M. Cleary, Nilofer S. Azad, Anita Ahmed Turk, Xiaojian Xu, Mitesh J. Borad, Kyriakos P. Papadopoulos, Sani H. Kizilbash
Publikováno v:
Journal of Clinical Oncology. 39:TPS350-TPS350
TPS350 Background: Mutations in isocitrate dehydrogenase 1 (mIDH1) are found in approximately 20-30% of patients with intrahepatic cholangiocarcinoma (CCA), and less commonly in glioma, chondrosarcoma, and other gastrointestinal malignancies. Despite