Zobrazeno 1 - 10
of 11
pro vyhledávání: '"James Michael Crawforth"'
Autor:
Peter J. Bungay, Martin Corless, Sarah Elizabeth Skerratt, Joseph S. Warmus, Sharan K. Bagal, C. Elizabeth Payne, Miller Duncan Charles, Kemp Mark Ian, David R. Fenwick, Paul Blackwell, Yoshihisa Murata, Bruce Brown, Laia Malet Sanz, David Fengas, James Michael Crawforth, Victoria Gray, Wolfgang Klute, Alan Daniel Brown, David C. Blakemore, Edward B. Stevens
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:230-239
The voltage gated sodium channel NaV1.8 has been postulated to play a key role in the transmission of pain signals. Core hopping from our previously reported phenylimidazole leads has allowed the identification of a novel series of benzimidazole NaV1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e6d7bdec8ba99cc4c8028429e49758f
https://doi.org/10.1016/j.bmc.2018.12.002
https://doi.org/10.1016/j.bmc.2018.12.002
Autor:
Wesley Peter Blackaby, Susan M. Cook, Alison J. Smith, Sarah Kelly, N. Brown, John R. Atack, Pushpinder Ferris, José L. Castro, Simon Charles Goodacre, Bindi Sohal, James Michael Crawforth, Joanna Stanley, Keith A. Wafford, David James Hallett, Andrew Pike, Richard Thomas Lewis, Leslie J. Street, George R. Marshall, Andrew Pate Owens
Publikováno v:
Journal of Medicinal Chemistry. 49:35-38
A series of high-affinity GABA(A) agonists with good oral bioavailability in rat and dog and functional selectivity for the GABA(A)alpha2 and -alpha3 subtypes is reported. The 7-trifluoromethylimidazopyrimidine 14g and the 7-propan-2-olimidazopyrimid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b0dd96fcc598d89a504d83e49c338d
https://doi.org/10.1021/jm051065l
https://doi.org/10.1021/jm051065l
Autor:
Andrew Pate Owens, Bindi Sohal, James Michael Crawforth, Alan Nadin, Alison J. Smith, Michael Rowley, Karl Richard Gibson, Andrew Pike, Francine Sternfeld, Keith A. Wafford, John R. Atack, Leslie J. Street, Susan M. Cook
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1679-1682
A series of tricyclic pyridones has been evaluated as benzodiazepine site ligands with functional selectivity for the alpha(3) over the alpha(1) containing subtype of the human GABA(A) receptor ion channel. This investigation led to the identificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54850564fd0bb737337cbacb989fd4d
https://doi.org/10.1016/j.bmcl.2004.01.057
https://doi.org/10.1016/j.bmcl.2004.01.057
Publikováno v:
Tetrahedron Letters. 50:4916-4918
A one-pot synthesis of imidazo[1,5-a]pyridines starting from a carboxylic acid and 2-methylaminopyridines allowing introduction of various substituents at the 1- and 3-positions is achieved using propane phosphoric acid anhydride in ethyl or n-butyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80d9787f7699b4e762f118d558c94d3b
https://doi.org/10.1016/j.tetlet.2009.06.061
https://doi.org/10.1016/j.tetlet.2009.06.061
Autor:
Benjamin S. Hickman, Carmel M. McNamara, James Michael Crawforth, Timothy J. Norwood, Bernard J. Rawlings, Stephen Box
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :83-88
The high level incorporation of isotopically labelled sodium acetate and sodium propionate into amphotericin B is reported. Double quantum filtered heteronuclear single quantum coherence NMR (DQF-HSQC) is employed to demonstrate coupling between labe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::020d47fd3a85f968f0c30c534586e5fa
https://doi.org/10.1039/a704545j
https://doi.org/10.1039/a704545j
Publikováno v:
ChemInform. 26
Enantiopure (S)-(−)-paraconic acid 2 has been synthesised by the stereospecific benzyloxymethylation of a titanium enolate derived from a homochiral oxazolidinone and dihydrocinnamoyl chloride.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dff3cc365e936b9c8567baefd6c8502
https://doi.org/10.1002/chin.199550216
https://doi.org/10.1002/chin.199550216
Publikováno v:
ChemInform. 29
The synthesis of enantiopure A-factor [‘autoregulatory factor’; (3R)-(–)-2-(6-methylheptanoyl)-3-hydroxymethylbutano-4-lactone] by the completely diastereoselective benzyloxymethylation of (4R)-3-(3-phenylpropanoyl)-4-isopropyloxazolidin-2-one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f674ee04f0464feafa906426838ce554
https://doi.org/10.1002/chin.199840267
https://doi.org/10.1002/chin.199840267
Autor:
Richard H. Herbert, Rosemarie Marwood, Desmond O'Connor, Sylvie Bourrain, Smita Patel, Peter H. Hutson, Robert James Maxey, James Michael Crawforth, Michael Rowley, Simon Charles Goodacre
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2701-2703
A series of 3-(4-piperidinyl)- and 3-(8-aza-bicyclo[3.2.l]oct-3-yl)-2-phenyl-1 H -indoles have been prepared and evaluated as ligands for the h5-HT 2A receptor. 3-(8-Phenethyl-8-aza-bicyclo[3.2.l]oct-3-yI)-2-phenyl-1 H -indole is a high-affinity (1.2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836487a14eba1a967ef91b0f76468378
https://doi.org/10.1016/s0960-894x(00)00559-x
https://doi.org/10.1016/s0960-894x(00)00559-x
Publikováno v:
ChemInform. 40
A one-pot synthesis of imidazo[1,5-a]pyridines starting from a carboxylic acid and 2-methylaminopyridines allowing introduction of various substituents at the 1- and 3-positions is achieved using propane phosphoric acid anhydride in ethyl or n-butyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7e556737a58dda1fb2e11175ded7ed6
https://doi.org/10.1002/chin.200949159
https://doi.org/10.1002/chin.200949159
Autor:
Rosemarie Marwood, Michael Rowley, James Michael Crawforth, Robert James Maxey, Peter H. Hutson, Sylvie Bourrain, Desmond O'Connor, Richard H. Herbert, Simon Charles Goodacre, Smita Patel
Publikováno v:
ChemInform. 32
A series of 3-(4-piperidinyl)- and 3-(8-aza-bicyclo[3.2.l]oct-3-yl)-2-phenyl-1 H -indoles have been prepared and evaluated as ligands for the h5-HT 2A receptor. 3-(8-Phenethyl-8-aza-bicyclo[3.2.l]oct-3-yI)-2-phenyl-1 H -indole is a high-affinity (1.2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b1c61193098dad65f004eac8907ad50
https://doi.org/10.1002/chin.200111112
https://doi.org/10.1002/chin.200111112