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Follow-up Blood Culture Practices for Gram-Negative Bloodstream Infections in Immunocompromised Hosts at a Large Academic Medical Center

Autor: Lauren Groft Buzzalino, James Mease, Ciera L Bernhardi, Jacqueline T Bork, J Kristie Johnson, Kimberly C Claeys

Publikováno v: Open forum infectious diseases. 9(5)

The role of follow-up blood cultures (FUBCs) in gram-negative bloodstream infections to improve clinical outcomes remains controversial, especially among immunocompromised patients. Among 139 patients, FUBCs were common (117, 84.2%); however, positiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6774d37189f8299cb62524bfb3e30e18
https://pubmed.ncbi.nlm.nih.gov/35531383

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1024. Using DOOR-MAT to Theoretically Compare Three Rapid Diagnostic Tests for Gram-Negative Bloodstream Infections in Immunocompromised Patients

Autor: Lauren Groft, Mandee Noval, James Mease, J Kristie Johnson, Kimberly C Claeys

Publikováno v: Open Forum Infectious Diseases

Background Molecular rapid diagnostic tests (RDTs) for bloodstream infections (BSI) utilize a variety of technologies and differ substantially in organisms and resistance mechanisms detected. RDT platforms decrease time to optimal antibiotics; howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66129d24b57fe28f8a8f32103ce0008
http://europepmc.org/articles/PMC8644924

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Total Synthesis of Cladosins B and C

Autor: Keith P. Reber, James Mease, Justin Kim

Publikováno v: The Journal of organic chemistry. 85(17)

A convergent synthetic route to the fungal metabolites cladosins B and C has been developed, affording these natural products in 29% and 27% overall yield, respectively. The cladosins are rare examples of hybrid polyketides featuring a 3-enamine tetr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0a6ab1dce1ff2b3ca9944208554043
https://pubmed.ncbi.nlm.nih.gov/32786634

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62. Follow-Up Blood Culture Practices for Gram-Negative Bloodstream Infections in Immunocompromised Hosts at a Large Academic Medical Center

Autor: Lauren Groft, James Mease, Jacqueline Bork, Ciera L Bernhardi, J Kristie Johnson, Kimberly C Claeys

Publikováno v: Open Forum Infectious Diseases

Background Routine follow-up blood cultures (FUBC) are strongly recommended for Staphylococcus aureus and Candida spp. bloodstream infections (BSI), but the role of FUBC in Gram-negative (GN) BSI remains controversial. Factors that may result in pers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d739a55b104446a661e49539368493
http://europepmc.org/articles/PMC8643888

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Total Synthesis of Clerobungin A via a Cascade Cyclization Reaction

Autor: Keith P. Reber, James Mease

Publikováno v: The Journal of Organic Chemistry. 81:12006-12011

The first total synthesis of the novel cyclohexylethanoid natural product clerobungin A has been achieved in six steps and 14% overall yield starting from commercially available tyrosol. Key steps in this sequence include a bioinspired oxidative dear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8223fbf3dfd330c50e88d5b63172b12c
https://doi.org/10.1021/acs.joc.6b02261

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