Zobrazeno 1 - 4
of 4
pro vyhledávání: '"James McSally"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
DNA is found in a dynamic equilibrium between standard Watson-Crick (WC) base pairs and non-standard Hoogsteen (HG) base pairs. Here the authors describe the influence of echinomycin and actinomycin D ligands binding on the HG-WC base pair dynamics i
Externí odkaz:
https://doaj.org/article/b13b41ea233f4bdb8b17d86942bc33d6
Autor:
Christoph Kreutz, James McSally, Gianmarc Grazioli, Isaac J. Kimsey, Christoph H. Wunderlich, Evgenia N. Nikolova, Ioan Andricioaei, Bharathwaj Sathyamoorthy, Huiqing Zhou, Tianyu Bai, Hashim M. Al-Hashimi
Publikováno v:
Nature Structural & Molecular Biology. 23:803-810
The B-DNA double helix can dynamically accommodate G-C and A-T base pairs in either Watson-Crick or Hoogsteen configurations. Here, we show that G-C(+) (in which + indicates protonation) and A-U Hoogsteen base pairs are strongly disfavored in A-RNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0914943ce7b30d8b81b06a22167c2e2
https://doi.org/10.1038/nsmb.3270
https://doi.org/10.1038/nsmb.3270
Autor:
Dhiraj Sinha, James McSally, Olga Ettrichova, Rüdiger Ettrich, David Reha, Balasubramanian Harish, Zdenek Kukacka, Petr Novák, Jannette Carey
Publikováno v:
Journal of Molecular Modeling. 20
WrbA is a novel multimeric flavodoxin-like protein of unknown function. A recent high-resolution X-ray crystal structure of E. coli WrbA holoprotein revealed a methionine sulfoxide residue with full occupancy in the FMN-binding site, a finding that w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4b0a5f433ad8d065f01ec7ca1ab632
https://doi.org/10.1007/s00894-014-2400-8
https://doi.org/10.1007/s00894-014-2400-8
Autor:
Ioan Andricioaei, James McSally
Publikováno v:
Biophysical Journal. 110:405a
The conformations that DNA takes are often vital in many biological processes. The physical effects Hoogsteen conformation base pairs have on the full strand of DNA are still being determined. Through molecular dynamics simulations in CHARMM, the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abed4341f27f4195f499b7e604ae8ede
https://doi.org/10.1016/j.bpj.2015.11.2186
https://doi.org/10.1016/j.bpj.2015.11.2186