Zobrazeno 1 - 10
of 117
pro vyhledávání: '"James McGinty"'
Autor:
Hannah J. Gleneadie, Beatriz Fernandez-Ruiz, Alessandro Sardini, Mathew Van de Pette, Andrew Dimond, Rab K. Prinjha, James McGinty, Paul M. W. French, Hakan Bagci, Matthias Merkenschlager, Amanda G. Fisher
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
With the long-term goal of finding therapeutic options for Duchenne muscular dystrophy, a mouse model enabling simultaneous visualisation of Dmd and Utrn is described and inhibitors of PRC2 and ERK1/2 identified to increase utrophin expression.
Externí odkaz:
https://doaj.org/article/c6e9b4a0f39e4abeb7c2631bde5a7ad8
Autor:
Mathew Van de Pette, Andrew Dimond, António M. Galvão, Steven J. Millership, Wilson To, Chiara Prodani, Gráinne McNamara, Ludovica Bruno, Alessandro Sardini, Zoe Webster, James McGinty, Paul M. W. French, Anthony G. Uren, Juan Castillo-Fernandez, William Watkinson, Anne C. Ferguson-Smith, Matthias Merkenschlager, Rosalind M. John, Gavin Kelsey, Amanda G. Fisher
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Here the authors show that a high-fat diet in pregnant mice can release silencing of the imprinted Dlk1 locus in multiple generations of offspring. They found that this occurs via changes in microRNA expression at the locus of interest, as well as tr
Externí odkaz:
https://doaj.org/article/21c5cdaf517b495e8f2f75239a9fefc7
Autor:
Luca Guglielmi, Claire Heliot, Sunil Kumar, Yuriy Alexandrov, Ilaria Gori, Foteini Papaleonidopoulou, Christopher Barrington, Philip East, Andrew D. Economou, Paul M. W. French, James McGinty, Caroline S. Hill
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The role of the transcriptional effector SMAD4 in vertebrate embryo development remains unresolved. Here the authors show that in the absence of Smad4, dorsal/ventral embryo patterning is disrupted due to the loss of BMP signaling, while Nodal signal
Externí odkaz:
https://doaj.org/article/c3a7ce8f93434e77b3526dc4eb45c12f
Autor:
Mathew Van de Pette, Allifia Abbas, Amelie Feytout, Gráinne McNamara, Ludovica Bruno, Wilson K. To, Andrew Dimond, Alessandro Sardini, Zoe Webster, James McGinty, Eleanor J. Paul, Mark A. Ungless, Paul M.W. French, Dominic J. Withers, Anthony Uren, Anne C. Ferguson-Smith, Matthias Merkenschlager, Rosalind M. John, Amanda G. Fisher
Publikováno v:
Cell Reports, Vol 18, Iss 5, Pp 1090-1099 (2017)
Imprinted genes are regulated according to parental origin and can influence embryonic growth and metabolism and confer disease susceptibility. Here, we designed sensitive allele-specific reporters to non-invasively monitor imprinted Cdkn1c expressio
Externí odkaz:
https://doaj.org/article/aeadbe578f874a309d15e553d64a6531
Autor:
Thomas Watson, Natalie Andrews, Samuel Davis, Laurence Bugeon, Margaret D Dallman, James McGinty
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180309 (2017)
We describe the implementation of an OPT plate to perform optical projection tomography (OPT) on a commercial wide-field inverted microscope, using our open-source hardware and software. The OPT plate includes a tilt adjustment for alignment and a st
Externí odkaz:
https://doaj.org/article/8f08aa81849444cca0d6f2bee6a6321c
Autor:
Teresa Correia, Nicola Lockwood, Sunil Kumar, Jun Yin, Marie-Christine Ramel, Natalie Andrews, Matilda Katan, Laurence Bugeon, Margaret J Dallman, James McGinty, Paul Frankel, Paul M W French, Simon Arridge
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136213 (2015)
Optical projection tomography (OPT) provides a non-invasive 3-D imaging modality that can be applied to longitudinal studies of live disease models, including in zebrafish. Current limitations include the requirement of a minimum number of angular pr
Externí odkaz:
https://doaj.org/article/eae988d6cb564d16940f27eadabb8af0
Publikováno v:
2022 Physics Education Research Conference Proceedings.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23de44ca5698d9d6ed8e7e7851c51297
https://doi.org/10.1119/perc.2022.pr.fox
https://doi.org/10.1119/perc.2022.pr.fox
Publikováno v:
Journal of biophotonicsREFERENCES.
A single-shot adaptation of Optical Projection Tomography (OPT) for high-speed volumetric snapshot imaging of dynamic mesoscopic biological samples is presented. Conventional OPT has been applied to in vivo imaging of animal models such as D. rerio,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611f12c151aee62c6ec472e511cdc0c1
https://pubmed.ncbi.nlm.nih.gov/36087031
https://pubmed.ncbi.nlm.nih.gov/36087031
We present a single-shot adaptation of Optical Projection Tomography (OPT) for high-speed volumetric snapshot imaging of dynamic mesoscopic samples. Conventional OPT has been applied to in vivo imaging of animal models such as D. rerio but the sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9fb364cfd3de22216bc31568cc15d70
https://doi.org/10.1101/2021.10.15.464407
https://doi.org/10.1101/2021.10.15.464407
Autor:
James McGinty, Shiva Kothari, Spiro P. Pantazatos, Jens J. Holst, Allan Geliebter, Shaunte Baboumian
Publikováno v:
Neuroscience
Of current obesity treatments, bariatric surgery induces the most weight loss. Given the marked increase in the number of bariatric surgeries performed, elucidating the mechanisms of action is a key research goal. We compared whole brain activation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63086d3d4d8021711e42a1bec854db18
https://doi.org/10.1016/j.neuroscience.2019.01.061
https://doi.org/10.1016/j.neuroscience.2019.01.061