Zobrazeno 1 - 10 of 58 pro vyhledávání: '"James McCarty"'
1
Akademický článek
Insight Into Seeded Tau Fibril Growth From Molecular Dynamics Simulation of the Alzheimer’s Disease Protofibril Core
Autor: Cass Leonard, Christian Phillips, James McCarty
Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)
Aggregates of the microtubule associated tau protein are a major constituent of neurofibrillary lesions that define Alzheimer’s disease (AD) pathology. Increasing experimental evidence suggests that the spread of tau neurofibrillary tangles results
Externí odkaz: https://doaj.org/article/eb9038bebafb4b60a56b9234d54bbd00
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2
Akademický článek
Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions
Autor: Yanxian Lin, James McCarty, Jennifer N Rauch, Kris T Delaney, Kenneth S Kosik, Glenn H Fredrickson, Joan-Emma Shea, Songi Han
Publikováno v: eLife, Vol 8 (2019)
The mechanism that leads to liquid-liquid phase separation (LLPS) of the tau protein, whose pathological aggregation is implicated in neurodegenerative disorders, is not well understood. Establishing a phase diagram that delineates the boundaries of
Externí odkaz: https://doaj.org/article/b57e7f8c7ec848248749b46b5edeaf21
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5
Field-Theoretic Simulation Method to Study the Liquid-Liquid Phase Separation of Polymers
Autor: Saeed, Najafi, James, McCarty, Kris T, Delaney, Glenn H, Fredrickson, Joan-Emma, Shea
Publikováno v: Methods in molecular biology (Clifton, N.J.). 2563
Liquid-liquid phase separation (LLPS) is a process that results in the formation of a polymer-rich liquid phase coexisting with a polymer-depleted liquid phase. LLPS plays a critical role in the cell through the formation of membrane-less organelles,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88f75428275169434bf19b9ca1f2017e
https://pubmed.ncbi.nlm.nih.gov/36227467
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7
Pediatric Musculoskeletal Coccidioidomycosis in Central California: A Single Center Experience
Autor: Fouzia Naeem, Joseph Gerardi, Purushottam Gholve, Daniel Merriott, Rida Hassan, James McCarty
Publikováno v: The Pediatric infectious disease journal. 41(7)
Published literature on musculoskeletal coccidioidomycosis is sparse and limited to case reports and case series. This is one of the largest case series to describe the clinical presentation, diagnosis, medical and surgical management and outcomes of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7608f7b1095cb465223ebd5c24e7245
https://pubmed.ncbi.nlm.nih.gov/35389943
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8
Structures of Streptococcus pyogenes class A sortase in complex with substrate and product mimics provide key details of target recognition
Autor: D. Alex Johnson, Isabel M. Piper, Brandon A. Vogel, Sophie N. Jackson, Justin E. Svendsen, Hanna M. Kodama, Darren E. Lee, Katy M. Lindblom, James McCarty, John M. Antos, Jeanine F. Amacher
Publikováno v: Journal of Biological Chemistry. 298:102446
The cell wall is a critical extracellular barrier for bacteria and many other organisms. In bacteria, this structural layer consists of peptidoglycan, which maintains cell shape and structural integrity and provides a scaffold for displaying various
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88eb45335b8569e58f76eee2b04dd87e
https://doi.org/10.1016/j.jbc.2022.102446
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9
Insight Into Seeded Tau Fibril Growth From Molecular Dynamics Simulation of the Alzheimer’s Disease Protofibril Core
Autor: James McCarty, Cass Leonard, Christian Phillips
Publikováno v: Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 8 (2021)
Aggregates of the microtubule associated tau protein are a major constituent of neurofibrillary lesions that define Alzheimer’s disease (AD) pathology. Increasing experimental evidence suggests that the spread of tau neurofibrillary tangles results
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2cfbd04aa8fcf80e6331ca15838a46
https://doi.org/10.3389/fmolb.2021.624302
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10
Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis
Autor: Ruth Nussinov, Pritam Ganguly, Son Tung Ngo, Carol K. Hall, John E. Straub, Laura Dominguez, Alfonso De Simone, Guanghong Wei, Bikash R. Sahoo, Brianna Hnath, Ayyalusamy Ramamoorthy, Sylvain Lesné, Fabio Sterpone, Simone Melchionna, Nikolay V. Dokholyan, Yiming Wang, Jie Zheng, Rakez Kayed, Jiaxing Chen, Birgit Habenstein, Peter Faller, Philippe Derreumaux, Antoine Loquet, Mara Chiricotto, Birgit Strodel, Buyong Ma, Stepan Timr, James McCarty, Phuong H. Nguyen, Mai Suan Li, Andrew J. Doig, Joan-Emma Shea, Saeed Najafi, Yifat Miller
Publikováno v: Chemical Reviews
Chemical Reviews, American Chemical Society, 2021
Chemical Reviews, American Chemical Society, 2021, 121 (4), pp.2545-2647. ⟨10.1021/acs.chemrev.0c01122⟩
Chemical reviews (2021): 2545–2647. doi:10.1021/acs.chemrev.0c01122
info:cnr-pdr/source/autori:Nguyen P.H.; Ramamoorthy A.; Sahoo B.R.; Zheng J.; Faller P.; Straub J.E.; Dominguez L.; Shea J.-E.; Dokholyan N.V.; De Simone A.; Ma B.; Nussinov R.; Najafi S.; Ngo S.T.; Loquet A.; Chiricotto M.; Ganguly P.; McCarty J.; Li M.S.; Hall C.; Wang Y.; Miller Y.; Melchionna S.; Habenstein B.; Timr S.; Chen J.; Hnath B.; Strodel B.; Kayed R.; Lesne S.; Wei G.; Sterpone F.; Doig A.J.; Derreumaux P./titolo:Amyloid Oligomers: A Joint Experimental%2FComputational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis/doi:10.1021%2Facs.chemrev.0c01122/rivista:Chemical reviews/anno:2021/pagina_da:2545/pagina_a:2647/intervallo_pagine:2545–2647/volume
Chemical reviews 121(4), 2545-2647 (2021). doi:10.1021/acs.chemrev.0c01122
Chem Rev
International audience; Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. Structural and dynamic characterization of all species along the pat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9bcb0310fc32a8257da65e0ea9a275e
http://hdl.handle.net/11588/839306
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