Zobrazeno 1 - 4
of 4
pro vyhledávání: '"James Matthew Bailey"'
Autor:
Nigel Deeks, Robert J. Watson, James Matthew Bailey, Simon Taylor, Jessica F. Renaux, Andrea C. Haynes, Simon J. Dowell, Rino A. Bit, Colin David Eldred, Colin A. Campbell, Duncan S. Holmes, Jason Witherington, Umesh Kumar, Jack A. Brown, Mary A. Morse, Emmanuel Hubert Demont, Pam Gaskin, Chris A. Smethurst, Gail A. Seal, Greg J. Osborne, James Gray, Robert Willis, David Jonathan Hirst
Publikováno v:
Journal of medicinal chemistry. 59(3)
FTY720 is the first oral small molecule approved for the treatment of people suffering from relapsing-remitting multiple sclerosis. It is a potent agonist of the S1P1 receptor, but its lack of selectivity against the S1P3 receptor has been linked to
Autor:
Alison I. Muir, Izzy Boyfield, Kalindi Vaidya, Barry Sidney Orlek, Etienne Fleury, David G. Evans, Jackie S. Scott, Hindy Mok, Victoria J. Bolton, Ward John Gerard, Geoffrey Stemp, Tom D. Heightman, Kim L. Matthews, Kirk Lawless, Gareth J. Sanger, Fiona McKay, Alexander J. Stevens, Emma M. Jarvie, James Matthew Bailey, Susan Marie Westaway, Mervyn Thompson, Jonathan B. Basilla
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6452-6458
Optimisation of a series of benzazepine sulfonamide hit compounds identified from high throughput screening led to the discovery of a new series of tractable, potent motilin receptor agonists.
Autor:
Peter Henry Milner, Barry Sidney Orlek, James Matthew Bailey, Anthony Huxley, Gordon Bruton, Vicky Johnstone, Geoffrey Stemp
Publikováno v:
Synlett. 2009:1051-1054
An efficient four-step synthesis (requiring no purification) of Boc-protected 4,4'-dipiperidinyl ethers is described.
Autor:
June S. Almenoff, Stephen D. Pickett, Darren V. S. Green, Giovanni Vitulli, David Fram, Nancy A. Yuen, James Matthew Bailey, Juan I. Luengo, Mohammad Al-Ansari, Dana E. Vanderwall
Publikováno v:
Drug discovery today. 16(15-16)
Drug toxicity is a major cause of late-stage product attrition. During lead identification and optimization phases little information is typically available about which molecules might have safety concerns. A system was built linking chemistry, precl