Zobrazeno 1 - 10
of 413
pro vyhledávání: '"James Macdonald"'
Autor:
Evelyn S Vincow, Ruth E Thomas, Gillian Milstein, Gautam Pareek, Theo K Bammler, James MacDonald, Leo J Pallanck
Publikováno v:
PLoS Genetics, Vol 20, Iss 11, p e1011105 (2024)
Mutations in GBA (glucosylceramidase beta), which encodes the lysosomal enzyme glucocerebrosidase (GCase), are the strongest genetic risk factor for the neurodegenerative disorders Parkinson's disease (PD) and Lewy body dementia. Recent work has sugg
Externí odkaz:
https://doaj.org/article/6e0a6c4134194900a0a906d953cfae98
Autor:
Marcus C.B. Tan, Chelsea A. Isom, Yangzi Liu, David-Alexandre Trégouët, Lang Wu, Dan Zhou, Eric R. Gamazon, Sara Lindstrom, Lu Wang, Erin Smith, William Gordon, Astrid Van Hylckama Vlieg, Mariza De Andrade, Jennifer Brody, Jack Pattee, Jeffrey Haessler, Ben Brumpton, Daniel Chasman, Pierre Suchon, Ming-Huei Chen, Constance Turman, Marine Germain, Kerri Wiggins, James MacDonald, Sigrid Braekkan, Sebastian Armasu, Nathan Pankratz, Rabecca Jackson, Jonas Nielsen, Franco Giulianini, Marja Puurunen, Manal Ibrahim, Susan Heckbert, Theo Bammler, Kelly Frazer, Bryan McCauley, Kent Taylor, James Pankow, Alexander Reiner, Maiken Gabrielsen, Jean-François Deleuze, Chris O'Donnell, Jihye Kim, Barbara McKnight, Peter Kraft, John-Bjarne Hansen, Frits Rosendaal, John Heit, Bruce Psaty, Weihong Tang, Charles Kooperberg, Kristian Hveem, Paul Ridker, Pierre-Emmanuel Morange, Andrew Johnson, Christopher Kabrhel, Nicholas Smith
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105233- (2024)
Summary: Background: Two important questions regarding the genetics of pancreatic adenocarcinoma (PDAC) are 1. Which germline genetic variants influence the incidence of this cancer; and 2. Whether PDAC causally predisposes to associated non-malignan
Externí odkaz:
https://doaj.org/article/3420f9e9c9f34b658ac5d3b0471a4072
Autor:
Samuel Elliott Holbert, Jane Brennan, Sophia Cattaneo, Paul King, Justin Turcotte, James MacDonald
Publikováno v:
Journal of Orthopaedics, Trauma and Rehabilitation, Vol 31 (2024)
Introduction: As the number of annual total knee arthroplasty (TKA) procedures increases the number of revision surgeries will continue to increase. Several prior studies have identified various mechanisms of TKA failure and reported a number of reas
Externí odkaz:
https://doaj.org/article/7194b1395f854b19ab97884e3c437fe4
Autor:
Gregory R. McCracken, Glenn Patriquin, Todd F. Hatchette, Ross J. Davidson, Barbara Goodall, Lisa Barrett, James MacDonald, Charles Heinstein, Janice Pettipas, John Ross, Jason J. LeBlanc
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 5 (2024)
ABSTRACTAntigen-based rapid diagnostic tests (Ag-RDTs) were widely deployed to enhance SARS-CoV-2 testing capacity during the COVID-19 pandemic. Consistent with national guidance for low prevalence settings, positive Ag-RDTs were confirmed using nucl
Externí odkaz:
https://doaj.org/article/404004a92d7340c0b92c52d4a149acb6
Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons
Autor:
Alison G. Paquette, Samantha Lapehn, Sophie Freije, James MacDonald, Theo Bammler, Drew B. Day, Christine T. Loftus, Kurunthachalam Kannan, W. Alex Mason, Nicole R. Bush, Kaja Z LeWinn, Daniel A. Enquobahrie, Carmen Marsit, Sheela Sathyanarayana
Publikováno v:
Environment International, Vol 172, Iss , Pp 107763- (2023)
Background: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants originating from petrogenic and pyrogenic sources. PAH compounds can cross the placenta, and prenatal PAH exposure is linked to adverse infant and childhood health outcomes
Externí odkaz:
https://doaj.org/article/c4cd74552bc44701a3a9cc2bb65e95e2
Autor:
Daniel A. Enquobahrie, James MacDonald, Michael Hussey, Theo K. Bammler, Christine T. Loftus, Alison G. Paquette, Nora Byington, Carmen J. Marsit, Adam Szpiro, Joel D. Kaufman, Kaja Z. LeWinn, Nicole R. Bush, Frances Tylavsky, Catherine J. Karr, Sheela Sathyanarayana
Publikováno v:
Environment International, Vol 165, Iss , Pp 107310- (2022)
Background: While strong evidence supports adverse maternal and offspring consequences of air pollution, mechanisms that involve the placenta, a key part of the intrauterine environment, are largely unknown. Previous studies of air pollution and plac
Externí odkaz:
https://doaj.org/article/53e1dc16420d44d4b53a66ad58439927
Autor:
McKayla Kelly, BS, Justin Turcotte, PhD, MBA, Jacob Aja, PA-C, James MacDonald, MD, Paul King, MD
Publikováno v:
Arthroplasty Today, Vol 8, Iss , Pp 200-203 (2021)
Background: Intrathecal opioids have been used to reduce pain after total joint arthroplasty; however, the utility of these drugs is disputed. We examined the impact of eliminating intrathecal fentanyl on outcomes for patients undergoing direct anter
Externí odkaz:
https://doaj.org/article/dfa4478866be4f61bc5f618a7ec08aa1
Autor:
Christopher M. Schaupp, Dianne Botta, Collin C. White, David K. Scoville, Sengkeo Srinouanprachanh, Theo K. Bammler, James MacDonald, Terrance J. Kavanagh
Publikováno v:
Redox Biology, Vol 49, Iss , Pp 102213- (2022)
Antioxidant signaling/communication is among the most important cellular defense and survival pathways, and the importance of redox signaling and homeostasis in aging has been well-documented. Intracellular levels of glutathione (GSH), a very importa
Externí odkaz:
https://doaj.org/article/d20c70f4fe0e4b73a8d082327e1a98bc
Autor:
Mitchell Selhorst, Richard Rodenberg, Nick Padgett, Anastasia Fischer, Reno Ravindran, James MacDonald
Publikováno v:
International Journal of Sports Physical Therapy, Vol 16, Iss 1 (2021)
# Background and Purpose Half of adolescent athletes report low back pain (LBP) and there is a significant risk of vertebral injury in this population. The current model of care for adolescent athletes with LBP is to first confirm a medical diagnosis
Externí odkaz:
https://doaj.org/article/4c8328f4a7b84c7fae931b07e984cd37
Autor:
Chris Calkins, Emery Wilkerson, Felipe Ribeiro, Hope Hall, James MacDonald, Karla Wilke, Katherine Domenech
Publikováno v:
Meat and Muscle Biology, Vol 4, Iss 1 (2020)
This study evaluated the use of field peas during two phases of production on fresh beef quality. Cattle (n = 232) were assigned to one of six dietary treatments in a 3x2 factorial design consisting of 3 pasture and 2 finishing supplementations. The
Externí odkaz:
https://doaj.org/article/2731001abc70452cab3c5e6a0d445c03