Zobrazeno 1 - 10
of 27
pro vyhledávání: '"James M. Termini"'
Autor:
James M. Termini, José M. Martinez-Navio, Guangping Gao, Sebastian P. Fuchs, Ronald C. Desrosiers
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 204-217 (2021)
The absence of fucose on asparagine-297 of the human immunoglobulin G (IgG) heavy chain has been shown to enhance antibody-dependent cellular cytotoxicity (ADCC) activity by 10- to 100-fold compared to fucosylated antibody. Our lab is studying the us
Externí odkaz:
https://doaj.org/article/374014c5546c4147b35ded0614fa653e
Autor:
James M Termini, Sachin Gupta, Francesca N Raffa, Elizabeth Guirado, Margaret A Fischl, Liguo Niu, Saravana Kanagavelu, Geoffrey W Stone
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184915 (2017)
Dendritic cells (DC) are a promising cell type for cancer vaccines due to their high immunostimulatory capacity. However, improper maturation of DC prior to treatment may account for the limited efficacy of DC vaccine clinical trials. Latent Membrane
Externí odkaz:
https://doaj.org/article/448aad0fe5154a0d839799023da9a83b
Autor:
James M Termini, Zachary A Silver, Bryony Connor, Aristotelis Antonopoulos, Stuart M Haslam, Anne Dell, Ronald C Desrosiers
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179949 (2017)
Here we describe derivatives of the HEK293T cell line that are defective in their ability to generate mucin-type O-linked glycosylation. Using CRISPR/Cas9 and a single-cell GFP-sorting procedure, the UDP-galactose-4-epimerase (GALE), galactokinase 1
Externí odkaz:
https://doaj.org/article/0ca73c9c36e24a4aab8eb428da646c41
Autor:
Sebastian P. Fuchs, Guangping Gao, James M. Termini, Ronald C. Desrosiers, José M. Martinez-Navio
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 204-217 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
The absence of fucose on asparagine-297 of the human immunoglobulin G (IgG) heavy chain has been shown to enhance antibody-dependent cellular cytotoxicity (ADCC) activity by 10- to 100-fold compared to fucosylated antibody. Our lab is studying the us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa44ade5efbd4e54b91ee5fd852d403e
http://www.sciencedirect.com/science/article/pii/S232905012030228X
http://www.sciencedirect.com/science/article/pii/S232905012030228X
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148929 (2016)
Type I interferon is known to inhibit HIV-1 replication through the induction of interferon stimulated genes (ISG), including a number of HIV-1 restriction factors. To better understand interferon-mediated HIV-1 restriction, we constructed a constitu
Externí odkaz:
https://doaj.org/article/e815691c03964fc4a1a1c7e422557420
Autor:
Saravana Kanagavelu, James M Termini, Sachin Gupta, Francesca N Raffa, Katherine A Fuller, Yaelis Rivas, Sakhi Philip, Richard S Kornbluth, Geoffrey W Stone
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90100 (2014)
Adenoviral vectored vaccines have shown considerable promise but could be improved by molecular adjuvants. Ligands in the TNF superfamily (TNFSF) are potential adjuvants for adenoviral vector (Ad5) vaccines based on their central role in adaptive imm
Externí odkaz:
https://doaj.org/article/aefbed439bb74e47bfe996434dee1576
Autor:
Margaret A. Fischl, Mary A Fletcher, Geoffrey W. Stone, Sachin Gupta, Kristopher L. Arheart, Dunja Z. Babic, Hector Bolivar, James M. Termini, Suresh Pallikkuth, Frank Y. Tung, Lesley R. de Armas, Savita Pahwa, Mario Stevenson
Publikováno v:
Vaccine. 38(27)
HIV infection is characterized by chronic immune activation and the establishment of a pool of latently infected cells. Antiretroviral therapy (ART) can suppress viral load to undetectable levels in peripheral blood by standard measure, however immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9b80e6be2832c0cae4d7543096a367
https://pubmed.ncbi.nlm.nih.gov/32387010
https://pubmed.ncbi.nlm.nih.gov/32387010
Autor:
Kurt Schesser, Saravana Kanagavelu, Reldy Riveron, James M. Termini, Claudia Flores, Moshe Arditi, Masayuki Fukata, Jose Ruiz, Laura Romero
Publikováno v:
Infection and Immunity. 83:4404-4415
Induction of adaptive immunity leads to the establishment of immunological memory; however, how innate immunity regulates memory T cell function remains obscure. Here we show a previously undefined mechanism in which innate and adaptive immunity are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40a8cd86feaaae1de47ecb5399d8e21
https://doi.org/10.1128/iai.00674-15
https://doi.org/10.1128/iai.00674-15
Autor:
Justin Boucher, Sakhi Abraham, Wasif N. Khan, David C. Montefiori, Saravana Kanagavelu, Celia C LeBranche, Geoffrey W. Stone, Sachin Gupta, James M. Termini, Emily S. Clark
Publikováno v:
Journal of Virology. 89:4158-4169
Broadly neutralizing antibodies (bNAbs) specific for conserved epitopes on the HIV-1 envelope (Env) are believed to be essential for protection against multiple HIV-1 clades. However, vaccines capable of stimulating the production of bNAbs remain a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e70e723787b2bb10645296ff5cabd9
https://doi.org/10.1128/jvi.02904-14
https://doi.org/10.1128/jvi.02904-14
Autor:
Ronald C. Desrosiers, Helen S. Maxwell, Diogo M. Magnani, Glen N. Barber, Jerilyn K. Pecotte, James M. Termini, David I. Watkins, Iris Castro, William A. Lauer
Publikováno v:
Journal of Virology. 91
Baboons naturally infected with simian T lymphotropic virus (STLV) are a potentially useful model system for the study of vaccination against human T lymphotropic virus (HTLV). Here we expanded the number of available full-length baboon STLV-1 sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dad077c7bac99da3b71f66e3d80ea8bb
https://doi.org/10.1128/jvi.00950-17
https://doi.org/10.1128/jvi.00950-17