Zobrazeno 1 - 10
of 44
pro vyhledávání: '"James M. Staddon"'
Autor:
Roberta Tufi, Emily H. Clark, Tamaki Hoshikawa, Christiana Tsagkaraki, Jack Stanley, Kunitoshi Takeda, James M. Staddon, Thomas Briston
Publikováno v:
SLAS Discovery, Vol 28, Iss 3, Pp 73-87 (2023)
Mitochondrial dysfunction and aberrant mitochondrial homeostasis are key aspects of Parkinson's disease (PD) pathophysiology. Mutations in PINK1 and Parkin proteins lead to autosomal recessive PD, suggesting that defective mitochondrial clearance via
Externí odkaz:
https://doaj.org/article/baab2dcd99a8404dbebb837a80359c4c
Autor:
Malcolm Roberts, Ioanna Sevastou, Yoichi Imaizumi, Kavita Mistry, Sonia Talma, Madhurima Dey, Jane Gartlon, Hiroshi Ochiai, Zhi Zhou, Shigeru Akasofu, Naoki Tokuhara, Makoto Ogo, Muneo Aoyama, Hirofumi Aoyagi, Kate Strand, Ezat Sajedi, Kishan Lal Agarwala, Jared Spidel, Earl Albone, Kanta Horie, James M. Staddon, Rohan de Silva
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-24 (2020)
Abstract Tau deposition in the brain is a pathological hallmark of many neurodegenerative disorders, including Alzheimer’s disease (AD). During the course of these tauopathies, tau spreads throughout the brain via synaptically-connected pathways. S
Externí odkaz:
https://doaj.org/article/cf9ba45bb1404bada124e68471e39a3e
Autor:
Natalie J. Welsh, Christina A. Gewinner, Kavita Mistry, Mumta Koglin, Juniebel Cooke, Matthew Butler, Ben Powney, Malcolm Roberts, James M. Staddon, Anthony H. V. Schapira
Publikováno v:
Haematologica, Vol 105, Iss 5 (2020)
Externí odkaz:
https://doaj.org/article/5fd77889cc7f42b39850d05ee57795c8
Autor:
Roberta Tufi, Emily H. Clark, Tamaki Hoshikawa, Christiana Tsagkaraki, Jack Stanley, Kunitoshi Takeda, James M. Staddon, Thomas Briston
Mitochondrial dysfunction and aberrant mitochondrial homeostasis are key aspects of Parkinson’s disease (PD) pathophysiology. Mutations in PINK1 and Parkin proteins lead to autosomal recessive PD, suggesting that defective mitochondrial clearance v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0f8f1284f217941c1d8ad8e36c73d3
https://doi.org/10.1101/2022.09.30.509127
https://doi.org/10.1101/2022.09.30.509127
Autor:
Tamaki Hoshikawa, Toru Watanabe, Makoto Kotake, Nathalie Tiberghien, Chi-kit Woo, Sian Lewis, Thomas Briston, Mumta Koglin, James M. Staddon, Ben Powney, Anthony H.V. Schapira, Andrew K. Takle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 81:129130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e01342b6e0eefce9a4b4300d7666bd
https://doi.org/10.1016/j.bmcl.2023.129130
https://doi.org/10.1016/j.bmcl.2023.129130
Autor:
Stephen J. Neame, Janhavi Limaye, John Hardy, Katharina Cosker, Jennifer M. Pocock, Thomas M. Piers, James M. Staddon, Anna Mallach
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
The R47H variant of the microglial membrane receptor TREM2 is linked to increased risk of late onset Alzheimer’s disease. Human induced pluripotent stem cell derived microglia (iPS-Mg) from patient iPSC lines expressing the AD-linked R47Hhet TREM2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1e6a1ef081eb7a32250ff1f0046e30
https://doi.org/10.1038/s41598-021-91207-1
https://doi.org/10.1038/s41598-021-91207-1
Autor:
Kunitoshi Takeda, Alison S. Walker, Toru Watanabe, Bianca Ramazio, Eliona Tsefou, Amy R. Hicks, Robin Ketteler, Christin Luft, James M. Staddon, Emily H. Clark, Thomas Briston
Publikováno v:
Biochemical Journal
SummaryMitochondrial dysfunction is implicated in Parkinson disease (PD). Mutations in Parkin, an E3 ubiquitin ligase, can cause juvenile-onset Parkinsonism probably through impairment of mitophagy. Inhibition of the de-ubiquitinating enzyme USP30 ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ad87e9eb89c5b048903abab6a8ecc3
https://doi.org/10.1101/2021.02.02.429344
https://doi.org/10.1101/2021.02.02.429344
Autor:
Stephen J. Neame, James M. Staddon, Katharina Cosker, Jennifer M. Pocock, Janhavi Limaye, John Hardy, Anna Mallach, Thomas M. Piers
The R47H variant of the microglial membrane receptor TREM2 is linked to increased risk of late onset Alzheimer’s disease. Human induced pluripotent stem cell derived microglia (iPS-Mg) from patient iPSC lines expressing the AD-linked R47Hhet TREM2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e0aa312a5f1fbe950e2e38283690cc6
https://doi.org/10.1101/2020.09.08.288043
https://doi.org/10.1101/2020.09.08.288043
Autor:
Matthew Butler, Mumta Koglin, Kavita Mistry, Malcolm Roberts, James M. Staddon, Ben Powney, Anthony H.V. Schapira, Christina A. Gewinner, Juniebel Cooke, Natalie J. Welsh
Publikováno v:
Haematologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2615fdd41b14cc3da05574803a055f
https://europepmc.org/articles/PMC7193507/
https://europepmc.org/articles/PMC7193507/
Autor:
Jared Spidel, Hirofumi Aoyagi, Muneo Aoyama, James M. Staddon, Kishan Agarwala, Rohan de Silva, Zhi Zhou, Shigeru Akasofu, Madhurima Dey, Naoki Tokuhara, Sonia Talma, Hiroshi Ochiai, Ioanna Sevastou, Jane Gartlon, Kanta Horie, Malcolm Roberts, Kate Strand, Makoto Ogo, Earl Albone, Kavita Mistry, Yoichi Imaizumi, Ezat Sajedi
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-24 (2020)
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-24 (2020)
Tau deposition in the brain is a pathological hallmark of many neurodegenerative disorders, including Alzheimer’s disease (AD). During the course of these tauopathies, tau spreads throughout the brain via synaptically-connected pathways. Such propa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841ef62019142d764f4c8f42e3d1cd52
https://pubmed.ncbi.nlm.nih.gov/32019610
https://pubmed.ncbi.nlm.nih.gov/32019610