Zobrazeno 1 - 10
of 55
pro vyhledávání: '"James M. Riordan"'
Autor:
Vibha Pathak, Ashish K. Pathak, Robert C. Reynolds, Gurdyal S. Besra, Sudagar S. Gurcha, Lainne E. Seitz, James M. Riordan
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:5629-5650
Glycosyltransferases (GTs) play a crucial role in mycobacterial cell wall biosynthesis and are necessary for the survival of mycobacteria. Hence, these enzymes are potential new drug targets for the treatment of tuberculosis (TB), especially multiple
Autor:
W. David Sedwick, Shiela R. Campbell, William J. Suling, Roy L. Kisliuk, David W. Borhani, Robert C. Reynolds, William R. Waud, Ralph G. Fairchild, A.K.W. Leung, Richard W. Dixon, James M. Riordan, Sherry F. Queener, Peggy L. Micca
Publikováno v:
Journal of Medicinal Chemistry. 50:3283-3289
Two boron-containing, ortho-icosahedral carborane lipophilic antifolates were synthesized, and the crystal structures of their ternary complexes with human dihydrofolate reductase (DHFR) and dihydronicotinamide adenine dinucleotide phosphate were det
Autor:
Robert C. Reynolds, James M. Riordan, Ashish K. Pathak, Sudagar S. Gurcha, Vibha Pathak, Gurdyal S. Besra
Publikováno v:
Carbohydrate Research. 339:683-691
Mannosyltransferases play a crucial role in mycobacterial cell-wall biosynthesis and are potential new drug targets for the treatment of tuberculosis. Herein, we describe the synthesis of α-(1 → 2)- and α-(1 → 6)-linked mannopyranosyl disacchar
Publikováno v:
Tetrahedron. 57:9899-9909
The enantioselective preparation of key intermediates in the synthesis of transition state analogues of hypoxanthine-guanine phosphoribosyltransferase, (1S,2S,3R,4R)-4-acetoxymethyl-1-bromomethyl-2,3-isopropylidenedioxy-1-toluenesulfonamidocyclopenta
Autor:
John A. Montgomery, Kamal N. Tiwari, Anita T. Shortnacy-Fowler, Lea Messini, John A. Secrist, James M. Riordan, Scott C. Meyers, Steven E. Ealick
Publikováno v:
Journal of Medicinal Chemistry. 41:3865-3871
A series of 4'-thio-D-arabinofuranosylpurine nucleosides was prepared and evaluated as potential anticancer agents. The details of a convenient and high-yielding synthesis of the carbohydrate precursor 1-O-acetyl-2,3,5-tri-O-benzyl-4-thio-D-arabinofu
Publikováno v:
Journal of Carbohydrate Chemistry. 16:1159-1177
Selective C-6 hydroxyl triphenylmethylation of methyl 2,3-O-isopropylidene-α-D-mannofuranose (1), followed by C-5 hydroxyl oxidation and sequential removal of protecting groups in aqueous acid, yielded D-lyxo-hexos-5-ulose (5-keto-mannose, 5) as a m
Publikováno v:
Tetrahedron. 52:405-424
Retinyl propynyl ether (RPE) undergoes an intramolecular Diels-Alder reaction to form a tetrahydroisobenzofuran derivative by addition of the alkyne group at positions 11 and 14 of the retinoid side chain. The Diels-Alder product can be isolated afte
Autor:
James M. Riordan, William B. Parker, William R. Waud, Paula W. Allan, John A. Secrist, Rashmi Khare, Abdalla E. A. Hassan, Reham A. I. Abou-Elkhair, John A. Montgomery
Publikováno v:
ChemInform. 43
Pd(IV)-Mediated cross-coupling reactions of ribofuranosylpurine (I) with organozinc halides (II) and subsequent deprotection afford the C-6 substituted purine ribosides (III) in satisfactory to high yields.
Publikováno v:
Journal of Medicinal Chemistry. 37:3051-3056
The introduction of substituents at position 3 of methyl 4-oxoretinoate can be effected in good yields by alkylating the lithium dienolate. A second substituent can be introduced also, but the resulting 3,3-disubstituted-4-oxoretinoates were isolated
Autor:
L. Lee Bennett, John A. Montgomery, James M. Riordan, John A. Secrist, Gregory A. Rener, William B. Parker, Robert D. Elliott
Publikováno v:
Journal of Medicinal Chemistry. 37:739-744
Cyclopentadiene was converted in six steps to the key intermediate (+/-)-(1 alpha,2 beta,4 alpha)-4-amino-2-(benzyloxy)cyclopentanol (10), which in turn was converted to the carbocyclic nucleoside analogs 14 and 19 by standard procedures developed in